Effects of Cortisone Acetate on Rheumatoid Arthritis

Boland, Edward W.; Headley, Nathan E.

doi:10.1001/jama.1949.02910050001001

Cited by 69 publications

(8 citation statements)

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“…This was demonstrated shortly after the synthesis of cortisone acetate and its application in the treatment of chronic inflammatory conditions, such as rheumatoid arthritis [1]. Subsequently, the term 'steroid diabetes' was introduced, but the condition at that time was considered to be rare [2].…”

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confidence: 99%

Steroid-induced hyperglycaemia in hospitalised patients: does it matter?

Cheung

2016

Diabetologia

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Steroid-induced hyperglycaemia is a common problem faced by endocrinologists in hospital wards. In this issue of Diabetologia, Popovic and colleagues (DOI 10.1007/s00125-016-4091-4) have conducted a subanalysis within a randomised controlled trial of prednisone therapy for community-acquired pneumonia. The authors found that the presence of diabetes or hyperglycaemia related to steroid therapy did not attenuate the clinical benefits of steroid therapy. The relevance and possible implications of these findings are discussed.

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confidence: 99%

Steroid-induced hyperglycaemia in hospitalised patients: does it matter?

Cheung

2016

Diabetologia

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“…This is regarded as being especially 228 ANNALS OF THE RHEUMATIC DISEASES true of the type of diabetes which begins in middle age, and is associated with obesity and arterial hypertension. In addition to the numerous investigations supporting this view which have been presented in the textbooks, it may be mentioned that, analogously with the earlier animal experiments, it has recently been noted that ACTH as well as cortisone is able to produce symptoms of diabetes mellitus in man (Boland and Headley, 1949;Br0chner-Mortensen and others, 1949;Conn and others, 1948). Therefore it may be assumed that the secretion of the antehypophyseal hormones (ACTH) and of the adrenocortical glucocorticoids.…”

Section: Discussionmentioning

confidence: 57%

A Study of the Interrelations of Rheumatoid Arthritis and Diabetes Mellitus

Järvinen¹

1950

Annals of the Rheumatic Diseases

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In investigations on the interrelations of rheumatoid arthritis and the various endocrine disturbances, very little attention has been paid to diabetes mellitus. Thus, there exist only short notes on the occurrence of rheumatoid arthritis among diabetics (Wolf, 1936), and only the effects of an insulin treatment given to rheumatoid arthritis patients have been subjected to a closer examination (Copeman, 1946). A further reason for analysing the interrelations of rheumatoid arthritis and diabetes mellitus was that an increased secretion of the adrenocortical glucocorticoids (as cortisone or Compound E) and of the antehypophyseal hormones (ACTH) is at present regarded as a feature of diabetes mellitus; and these hormones are those upon which the interest in rheumatoid arthritis is now concentrating.MaterialThe study comprises the rheumatoid arthritis and diabetes mellitus patients treated at the Third Medical Clinic of the University of Helsinki and in the medical wards of the Kivela Hospital during the 15-year period 1934-1948.Rheumatoid Arthritis Patients.-There were 1,008 in this group, of whom 725 were female and 283 male. The average age in the whole group was 48-7 years.Diabetes Mellitus Patients.-There were 766 altogether, of whom 490 were female and 276 male. The average age was 51 -6 years. Rheumatoid Arthritis and Diabetes Mellitus occurring in the same PatientIn the present series, 1 -3±0*36 per cent. of the rheumatoid arthritis patients were affected with diabetes mellitus, and 1*7±0*47 per cent. of the diabetes mellitus group suffered from rheumatoid arthritis.In order to know whether the present results show that these two diseases have a tendency either to occur together more often than is due to pure chance, or to avoid each other, the figures should be compared with the corresponding morbidity rates among similar population groups.According to earlier studies (Jarvinen, 1950)

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“…Thorn and his co-workers (Thorn et al, 1950) have reviewed the clinical usefulness of the hormone. Suppression of the manifestations of rheumatoid arthritis has been confirmed both in America (Boland and Headley, 1949) and in this country (Copeman etal., 1950). Juvenile rheumatoid arthritis has responded to this treatment in the same way as the adult form (Freyberg, 1950;Rosenberg, personal communication, 1950).…”

Section: Discussionmentioning

confidence: 78%

Use of Oral Cortisone in Paediatrics

Wolman¹

1951

BMJ

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SIMPLE GASTRIC ULCER AND CARCINOMA BDI ouIL pre-pyloric carcinomata frequently undergo peptic ulceration and may then present with the histological features of so-called " ulcer-cancer." We believe that the second possibility is inherently more likely. But, in any event, from a practical standpoint the main conclusion is unaffected by one's choice between these two possibilities. It is that pre-pyloric ulcers are commonly malignant and should be resected. SummaryAmong 375 patients with gastric carcinoma treated in the Radcliffe Infirmary there were 26 with some eviqence that the neoplasm might have arisen in a simple ulcer.There was good clinical evidence of chronic simple ulcer in only half the patients.The site of the neoplasm for the group -of 26 patients conformed with the distribution of carcinoma of the stomach and not with that of simple gastric ulcer.In three cases the carcinoma had apparently arisen at a site different from that of a pre-existing simple ulcer.We believe that most of these cases were examples of ulcerating carcinoma. In any event, the majority were prepyloric, and it is evident that pre-pyloric ulcers should be deemed malignant and treated by surgical resection.We wish to thank the physicians and surgeons of the Radcliffe Infirmary for permission to make the study out of which the present article arises.

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Effects of Cortisone Acetate on Rheumatoid Arthritis

Abstract: A crystalline steroid was isolated from the adrenal cortex by Kendall and co-workers in 1935

Cited by 69 publications

References 8 publications

Steroid-induced hyperglycaemia in hospitalised patients: does it matter?

Steroid-induced hyperglycaemia in hospitalised patients: does it matter?

A Study of the Interrelations of Rheumatoid Arthritis and Diabetes Mellitus

Use of Oral Cortisone in Paediatrics

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