2022
DOI: 10.1101/2022.12.30.22284067
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Effects of counteracting measures on muscle contraction determinants in CKD: what muscle biopsy studies tell us?

Abstract: Chronic kidney disease (CKD) is characterized by muscle atrophy, fatigue intolerance and other indicators of muscle dysfunction, collectively termed uremic myopathy, with devastating consequences in overall health status and mortality rates. Although many factors such as metabolic acidosis, substrate availability and neuropathy have been implicated, the mechanisms underlying uremic myopathy have not yet been fully understood. However, there is clear evidence that muscle specific factors such as fiber atrophy, … Show more

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