Effects of cranberry consumption on features of the metabolic syndrome: a systematic review and meta-analysis of randomized control trials

Abstract

Purpose The purpose of this paper with meta-analysis is to clarify the effects of cranberry consumption on features of the metabolic syndrome of interest of all relevant randomized controlled trials (RCTs). Design/methodology/approach A systematic literature search was conducted on ISI web of science, PubMed, Embase, the Cochrane library and Google Scholar databases, to include trials published up to March 2019. Weighted mean differences (WMD) were calculated from a random or fixed-effects models. Between‐study heterogeneity was assessed by Cochrane’s test and I2 index. Findings Ten RCTs were included in this review which involving a total of 371 subjects. Our meta-analysis showed that cranberry consumption had beneficial effects on waist circumference (WMD −0.49, 95% CI −0.96 to −0.036; p = 0.034). No significant effect of cranberry consumption on fasting blood glucose, high-density lipoprotein cholesterol, triglycerides and blood pressure was found in this meta-analysis. Originality/value To the best of the authors’ knowledge, this is the first systematic review with meta-analysis of RCTs that investigate the effect of cranberry consumption on features of the metabolic syndrome.

The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…Then, 2556 studies were excluded because of in vitro or animal studies and irrelevant outcomes. Finally, 40 full-text studies assessed the above criteria preliminary, and 16 of them were included for qualitative synthesis and meta-analysis [ 10 , 11 , 12 , 13 , 14 , 15 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. The flow chart for the literature search is shown in Figure 1 .…”

“…Table 1 lists the characteristics and main results of sixteen included studies published from 2006 to 2023 [ 10 , 11 , 12 , 13 , 14 , 15 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ] and nine published in the past five years [ 14 , 15 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. In total, 708 participants aged 18 to 80 were systematically reviewed in this analysis.…”

“…In total, 708 participants aged 18 to 80 were systematically reviewed in this analysis. Seven studies were from North America (United States and Canada) [ 11 , 24 , 25 , 26 , 27 , 30 , 31 ], five from Asia (Iran and Taiwan) [ 10 , 13 , 28 , 29 ], and four from Europe (United Kingdom and Germany) [ 12 , 15 , 32 , 33 ]. Only two of them were placebo-controlled crossover studies [ 25 , 31 ], whereas others were placebo-controlled, parallel design trials.…”

“…HOMA-IR is a practical way to assess insulin resistance levels related to the risk of CVD and type 2 diabetes [42]. Three included research studies demonstrated similar findings on HOMA-IR [11,14,29]. Apart from the influence on HOMA-IR, Novotny et al also discovered that individuals with higher baseline FBG had a more significant reduction after drinking cranberry juice [11].…”

Does strawberry supplementation ameliorate markers of cardiovascular and metabolic health? A systematic review and meta-analysis

“…Taken all together, the berries including strawberry which are the rich sources of bioactive compounds has beneficial effects on human health. Their preventive roles against many chronic disorders such as CVD, diabetes and cancer were discussed in many in vivo , in vitro and clinical studies (Hormoznejad et al , 2021; Cianciosi et al , 2019). Strawberry can effectively activate the MP-activated protein kinase (AMPK), which can regulate several biological mechanisms, such as oxidative stress and inflammation (Giampieri et al , 2017).…”