Effects of creatine supplementation on nociception in young male and female mice

Munoz, Haydee Izurieta; Gonzales, Eric B.; Sumien, Nathalie

doi:10.1016/j.pharep.2017.11.002

Cited by 8 publications

(4 citation statements)

References 42 publications

(56 reference statements)

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“…Increased levels of inflammation are related to pain in FM, suggesting that oxidative stress, mitochondrial dysfunction, and inflammation may have a role in its pathophysiology. 33 Considering the analgesic potential of Cr and its effect on inflammation-based nociception, 34 lower levels of Cr may contribute to mitochondrial dysfunction, inflammation, and pain in this disease. 33 Low levels of Cr/tCr were correlated with high stress and PTSD levels in FM patients in this study.…”

Section: Discussionmentioning

confidence: 99%

Dysfunctional energy metabolisms in fibromyalgia compared with healthy subjects

et al. 2021

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This study aimed to investigate the levels of creatine (Cr) metabolites in the anterior cingulate cortex (ACC), thalamus, and insula of patients with fibromyalgia (FM) using proton magnetic resonance spectroscopy (MRS). The levels of Cr and phosphocreatine (PCr) relative to total Cr (tCr), which includes Cr and PCr, in the ACC, thalamus, and insula were determined using MRS in 12 patients with FM and in 13 healthy controls. The FM group had lower levels of PCr/tCr in the ACC and right insula compared to healthy controls. There was a negative correlation between Cr/tCr in the ACC and total pain levels (McGill Pain Questionnaire-Total; r = −0.579, p = 0.049) and between Cr/tCr in the left insula and affective pain levels (McGill Pain Questionnaire-Affective; r = −0.638, p = 0.047) in patients with FM. In addition, there were negative correlations between stress levels (Stress Response Inventory) and Cr/tCr in the right (r = −0.780, p = 0.005) and left thalamus (r = −0.740, p = 0.006), as well as in the right insula (r = −0.631, p = 0.028) in patients with FM. There were negative correlations between symptom levels of post-traumatic stress disorder (PTSD; PTSD checklist) and Cr/tCr in the right (r = −0.783, p = 0.004) and left thalamus (r = −0.642, p = 0.024) of patients with FM. These findings are paramount to understanding the decisive pathologies related to brain energy metabolism in patients with FM.

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Section: Discussionmentioning

confidence: 99%

Dysfunctional energy metabolisms in fibromyalgia compared with healthy subjects

et al. 2021

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“…Pre-clinical mouse data ( n = 95) suggests that seven days of creatine supplementation (6.25 g⋅kg −1 ·day −1 ) can reduce nociception induced by inflammation (30 μL injection of 4% formalin solution to a hind paw) determined by the time spent licking the injected paw, which may be mediated through activation of acid-sensing ion channels (ASICs) [ 43 ]. More research is needed to fully understand the complexity of creatine supplementation protocols on acute and long-term inflammatory responses in various diseases.…”

Section: Anti-inflammatory Effects Of Creatine Supplementationmentioning

confidence: 99%

Anti-Inflammatory and Anti-Catabolic Effects of Creatine Supplementation: A Brief Review

2022

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It is well established that creatine supplementation, primarily when combined with resistance training, significantly increases measures of muscle mass and performance (primarily strength). Emerging research also indicates that creatine supplementation may have favorable effects on measures of bone biology. These anabolic adaptations may be related to creatine influencing cellular hydration status, high-energy phosphate metabolism, growth factors, muscle protein kinetics, and the bone remodeling process. Accumulating research also suggests that creatine supplementation has anti-inflammatory and anti-catabolic properties, which may help create a favorable environment for muscle and bone accretion and recovery from exercise. Creatine supplementation has the ability to decrease markers of inflammation and possibly attenuate cancerous tumor growth progression. From a musculoskeletal perspective, there is some evidence to show that creatine supplementation reduces measures of muscle protein catabolism (primarily in males) and bone resorption when combined with resistance training. The purpose of this brief review is to summarize the current body of literature examining the potential anti-inflammatory and anti-catabolic effects of creatine supplementation across various research populations.

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“…There is solid evidence in sports medicine, e.g., from ironman competitions, that creatine supplementation reduces the plasma levels of pro-inflammatory cytokines and prostaglandin E2 (PGE2) [ 45 ]. Very recent data have provided evidence that creatine may also have the potential to lower pain sensitivity associated with inflammation by antagonizing the acid-sensing ion channel (ASIC3) [ 46 ]. This effect is most likely based on the structural similarity of creatine, itself a guanidino compound, to other guanidino compound ligands of the ASIC3 pain receptor, such as GMQ and amiloride, that modulated this ion sensing channel [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

“…Very recent data have provided evidence that creatine may also have the potential to lower pain sensitivity associated with inflammation by antagonizing the acid-sensing ion channel (ASIC3) [ 46 ]. This effect is most likely based on the structural similarity of creatine, itself a guanidino compound, to other guanidino compound ligands of the ASIC3 pain receptor, such as GMQ and amiloride, that modulated this ion sensing channel [ 46 ]. Thus, one may expect from creatine supplementation, as an additional beneficial effect, an improvement of the abdominal pain associated with intestinal inflammation.…”

Section: Introductionmentioning

confidence: 99%

Creatine Supplementation for Patients with Inflammatory Bowel Diseases: A Scientific Rationale for a Clinical Trial

Wallimann

Hall

Colgan³

et al. 2021

Nutrients

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Based on theoretical considerations, experimental data with cells in vitro, animal studies in vivo, as well as a single case pilot study with one colitis patient, a consolidated hypothesis can be put forward, stating that “oral supplementation with creatine monohydrate (Cr), a pleiotropic cellular energy precursor, is likely to be effective in inducing a favorable response and/or remission in patients with inflammatory bowel diseases (IBD), like ulcerative colitis and/or Crohn’s disease”. A current pilot clinical trial that incorporates the use of oral Cr at a dose of 2 × 7 g per day, over an initial period of 2 months in conjunction with ongoing therapies (NCT02463305) will be informative for the proposed larger, more long-term Cr supplementation study of 2 × 3–5 g of Cr per day for a time of 3–6 months. This strategy should be insightful to the potential for Cr in reducing or alleviating the symptoms of IBD. Supplementation with chemically pure Cr, a natural nutritional supplement, is well tolerated not only by healthy subjects, but also by patients with diverse neuromuscular diseases. If the outcome of such a clinical pilot study with Cr as monotherapy or in conjunction with metformin were positive, oral Cr supplementation could then be used in the future as potentially useful adjuvant therapeutic intervention for patients with IBD, preferably together with standard medication used for treating patients with chronic ulcerative colitis and/or Crohn’s disease.

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Effects of creatine supplementation on nociception in young male and female mice

Cited by 8 publications

References 42 publications

Dysfunctional energy metabolisms in fibromyalgia compared with healthy subjects

Dysfunctional energy metabolisms in fibromyalgia compared with healthy subjects

Anti-Inflammatory and Anti-Catabolic Effects of Creatine Supplementation: A Brief Review

Creatine Supplementation for Patients with Inflammatory Bowel Diseases: A Scientific Rationale for a Clinical Trial

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