Effects of Crotalus durissus collilineatus venom in the isolated rat kidney

Amora, Daniela Nascimento; Sousa, Ticiana Meireles; Martins, Alice Maria Costa; Barbosa, Paula; Magalhães, Marta Regina; Toyama, Marcos H.; Fonteles, M. C.; Menezes, Dalgimar Beserra de; Monteiro, Helena Serra Azul

doi:10.1016/j.toxicon.2005.10.007

Cited by 15 publications

(7 citation statements)

References 20 publications

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“…Infusion of whole venom from Crotalus durissus terrificus caused no alteration in the PP, but augmented GFR and UF (27). On the other hand, Crotalus durissus collilineatus venom reduced all renal parameters, namely PP, RVR, UF, and GFR (28). Taken together, these results corroborate the existence of intraspecific variation in the biological effects induced by crotalic venoms (2).…”

Section: Discussionsupporting

confidence: 58%

Renal and vascular effects of Crotalus durissus cumanensis venom and its crotoxin fraction

Pereira¹,

Menezes²,

Torres³

et al. 2011

J. Venom. Anim. Toxins incl. Trop. Dis

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Abstract:In this study, we evaluated the actions of Crotalus durissus cumanensis venom (CDCmV), and its crotoxin (Crtx) fraction, on renal and vascular functions in Wistar rats. In isolated perfused kidneys, CDCmV (10 µg/mL) significantly increased the perfusion pressure (PP) from 110.7 ± 2.4 to 125.3 ± 2.8 mmHg after 30 minutes. This effect was accompanied by an increased renal vascular resistance (RVR) from 5.4 ± 0.1 to 6.2 ± 0.2 mmHg/mL.g ). Both CDCmV and Crtx reduced the percentage of tubular transport of sodium, chloride and potassium. The cytotoxicity of these substances against MDCK cells was tested by the MTT method: only CDCmV caused a decrease in the cell viability with an IC 50 of 5.4 µg/mL. In endothelium-intact isolated aortic rings, CDCmV (0.1 to 30 µg/mL) increased the sustained phenylephrineinduced contraction to a value of 130.0 ± 6.6% of its corresponding control, but showed a relaxant effect in endothelium-denuded preparations. Similar results were observed in aortic rings contracted with potassium (40 mM). Crtx was ineffective in aortic ring assays. Thus, it is reasonable to suggest that the renal effects induced by the CDCmV may be due to its influence on the endothelium's ability to release factors that can alter the contractile behavior of vascular smooth muscle. In conclusion, CDCmV is toxic to kidney cells. It changes parameters of the renal function including the glomerular filtration rate, renal vascular resistance and tubular transport. The actions induced by CDCmV also involve endothelium-dependent vasoactive properties. Their effects may be only partially attributed to Crtx.

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Section: Discussionsupporting

confidence: 58%

Renal and vascular effects of Crotalus durissus cumanensis venom and its crotoxin fraction

Pereira¹,

Menezes²,

Torres³

et al. 2011

J. Venom. Anim. Toxins incl. Trop. Dis

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“…Experimental models using C. durissus subspecies' venoms and isolated toxins showed important renal alterations, for which several mechanisms are proposed (129)(130)(131)(132). Possibly the most critical concern is the damage to skeletal muscle by the myotoxins crotoxin and crotamine, as discussed above.…”

Section: Rhabdomyolysis and Acute Renal Failurementioning

confidence: 96%

Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology

Pucca

Bernarde

Rocha³

et al. 2021

Front. Immunol.

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Crotalus durissus ruruima is a rattlesnake subspecies mainly found in Roraima, the northernmost state of Brazil. Envenomings caused by this subspecies lead to severe clinical manifestations (e.g. respiratory muscle paralysis, rhabdomyolysis, and acute renal failure) that can lead to the victim’s death. In this review, we comprehensively describe C. d. ruruima biology and the challenges this subspecies poses for human health, including morphology, distribution, epidemiology, venom cocktail, clinical envenoming, and the current and future specific treatment of envenomings by this snake. Moreover, this review presents maps of the distribution of the snake subspecies and evidence that this species is responsible for some of the most severe envenomings in the country and causes the highest lethality rates. Finally, we also discuss the efficacy of the Brazilian horse-derived antivenoms to treat C. d. ruruima envenomings in Roraima state.

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“…In a SINAN-based cross-country comparison, the frequency of acute renal failure was significantly higher in C. d. ruruima envenomings than in C. d. cascavella, C. d. terrificus, and C. d. collilineatus, even after adjustment by age, sex, and time to medical care (Figure 4). Experimental models using C. durissus subspecies' venoms and isolated toxins showed important renal alterations, for which several mechanisms are proposed [129][130][131][132]. Possibly the most critical concern is the damage to skeletal muscle by the myotoxins crotoxin and crotamine, as discussed above.…”

Section: Rhabdomyolysis and Acute Renal Failurementioning

confidence: 96%

Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology

Pucca¹,

Bernarde²,

Rocha³

et al. 2021

Prime Archives in Immunology

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Crotalus durissus ruruima is a rattlesnake subspecies mainly found in Roraima, the northernmost state of Brazil. Envenomings caused by this subspecies lead to severe clinical manifestations (e.g. respiratory muscle paralysis, rhabdomyolysis, and acute renal failure) that can lead to the victim's death. In this review we comprehensively describe C. d. ruruima biology and the challenges this subspecies poses for human health, including morphology, distribution, epidemiology, venom cocktail, clinical envenoming, and the current and future specific treatment of envenomings by this snake. Moreover, this review presents maps of the distribution of the snake subspecies and evidence that this species is responsible Prime Archives in Immunology: 2 nd Edition 4 www.videleaf.com for some of the most severe envenomings in the country and causes the highest lethality rates. Finally, we also discuss the efficacy of the Brazilian horse-derived antivenoms to treat C. d. ruruima envenomings in Roraima state.

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Effects of Crotalus durissus collilineatus venom in the isolated rat kidney

Cited by 15 publications

References 20 publications

Renal and vascular effects of Crotalus durissus cumanensis venom and its crotoxin fraction

Renal and vascular effects of Crotalus durissus cumanensis venom and its crotoxin fraction

Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology

Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology

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