Effects of crude oil on in situ cardiac function in young adult mahi–mahi ( Coryphaena hippurus )

Nelson, Derek; Heuer, Rachael M.; Cox, Georgina; Stieglitz, John D.; Hoenig, Ronald H.; Mager, Edward M.; Benetti, Daniel D.; Grosell, Martin; Crossley, Dane A.

doi:10.1016/j.aquatox.2016.10.012

Cited by 74 publications

(66 citation statements)

References 45 publications

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“…Moreover, relatively short‐term whole animal aquatic exposure (24 h) to crude oil was found to reduce cardiac stroke work and cardiac output (Nelson et al . ; Cox et al . ).…”

Section: Introductionmentioning

confidence: 99%

Polyaromatic hydrocarbons in pollution: a heart‐breaking matter

Marris

Kompella

Miller

et al. 2020

The Journal of Physiology

137

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Air pollution is associated with detrimental effects on human health, including decreased cardiovascular function. However, the causative mechanisms behind these effects have yet to be fully elucidated. Here we review the current epidemiological, clinical and experimental evidence linking pollution with cardiovascular dysfunction. Our focus is on particulate matter (PM) and the associated low molecular weight polycyclic aromatic hydrocarbons (PAHs) as key mediators of cardiotoxicity. We begin by reviewing the growing epidemiological evidence linking air pollution to cardiovascular dysfunction in humans. We next address the pollution‐based cardiotoxic mechanisms first identified in fish following the release of large quantities of PAHs into the marine environment from point oil spills (e.g. Deepwater Horizon). We finish by discussing the current state of mechanistic knowledge linking PM and PAH exposure to mammalian cardiovascular patho‐physiologies such as atherosclerosis, cardiac hypertrophy, arrhythmias, contractile dysfunction and the underlying alterations in gene regulation. Our aim is to show conservation of toxicant pathways and cellular targets across vertebrate hearts to allow a broad framework of the global problem of cardiotoxic pollution to be established. AhR; Aryl hydrocarbon receptor. Dark lines indicate topics discussed in this review. Grey lines indicate topics reviewed elsewhere.

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“…Moreover, relatively short‐term whole animal aquatic exposure (24 h) to crude oil was found to reduce cardiac stroke work and cardiac output (Nelson et al . ; Cox et al . ).…”

Section: Introductionmentioning

confidence: 99%

Polyaromatic hydrocarbons in pollution: a heart‐breaking matter

Marris

Kompella

Miller

et al. 2020

The Journal of Physiology

137

View full text Add to dashboard Cite

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“…Indeed, during the last few decades, mahi has become an emergent model for examining population genetics, developmental physiology, metabolic responses, nutritional physiology, egg and larval performance over time, and climate change effects . Mahi have also been studied extensively regarding the impact of environmental toxicants . The emergence of this model fish has been accelerated by the need to develop more sophisticated scientific approaches for understanding the impact of environmental stressors, especially the impacts of the Deepwater Horizon Oil spill in 2010.…”

Section: Introductionmentioning

confidence: 99%

“…15,16 Mahi have also been studied extensively regarding the impact of environmental toxicants. [17][18][19][20][21][22][23][24][25][26][27][28][29][30] The emergence of this model fish has been accelerated by the need to develop more sophisticated scientific approaches for understanding the impact of environmental stressors, especially the impacts of the Deepwater Horizon Oil spill in 2010. Immediate mortality or fitness declines have been shown in fin fish populations as a result of pollution exposure (see numerous chapters in Burggren and Dubansky 31 ).…”

mentioning

confidence: 99%

Mahi‐mahi (Coryphaena hippurus) life development: morphological, physiological, behavioral and molecular phenotypes

Perrichon

Stieglitz

et al. 2019

Developmental Dynamics

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Background Mahi‐mahi ( Coryphaena hippurus ) is a commercially and ecologically important fish species that is widely distributed in tropical and subtropical waters. Biological attributes and reproductive capacities of mahi‐mahi make it a tractable model for experimental studies. In this study, life development of cultured mahi‐mahi from the zygote stage to adult has been described. Results A comprehensive developmental table has been created reporting development as primarily detailed observations of morphology. Additionally, physiological, behavioral, and molecular landmarks have been described to significantly contribute in the understanding of mahi life development. Conclusion Remarkably, despite the vast difference in adult size, many developmental landmarks of mahi map quite closely onto the development and growth of Zebrafish and other warm‐water, active Teleost fishes.

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“…Stroke volume and ultimately cardiac output are critical for health and normal development (Burggren and Bagatto, 2008; Burggren et al, in press). Understanding the heart's mechanics is crucial for clinical or environmental research because many pathologies are strongly correlated with cardiac failure (Incardona et al, 2004, 2009; Nelson et al, 2016; Sørhus et al, 2016; Stieglitz et al, 2016). These impairments in cardiac function are often accompanied by accumulation of fluid (edema), as well as craniofacial and body defects (Incardona and Scholz, 2016; Sørhus et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…These impairments in cardiac function are often accompanied by accumulation of fluid (edema), as well as craniofacial and body defects (Incardona and Scholz, 2016; Sørhus et al, 2016). Physiological effects may appear as well, such as the decreased swimming performance in mahi-mahi ( Coryphaena hippurus ) associated with a reduction in cardiac contractility and blood ejection (Mager et al, 2014; Nelson et al, 2016; Stieglitz et al, 2016). No doubt, cardiac function is key factor to fish survival, and understanding how cardiac output develops in larval fishes will provide a powerful insight to physiological conditions of developing larvae as they face environmental challenges.…”

Section: Introductionmentioning

confidence: 99%

Heart Performance Determination by Visualization in Larval Fishes: Influence of Alternative Models for Heart Shape and Volume

2017

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Understanding cardiac function in developing larval fishes is crucial for assessing their physiological condition and overall health. Cardiac output measurements in transparent fish larvae and other vertebrates have long been made by analyzing videos of the beating heart, and modeling this structure using a conventional simple prolate spheroid shape model. However, the larval fish heart changes shape during early development and subsequent maturation, but no consideration has been made of the effect of different heart geometries on cardiac output estimation. The present study assessed the validity of three different heart models (the “standard” prolate spheroid model as well as a cylinder and cone tip + cylinder model) applied to digital images of complete cardiac cycles in larval mahi-mahi and red drum. The inherent error of each model was determined to allow for more precise calculation of stroke volume and cardiac output. The conventional prolate spheroid and cone tip + cylinder models yielded significantly different stroke volume values at 56 hpf in red drum and from 56 to 104 hpf in mahi. End-diastolic and stroke volumes modeled by just a simple cylinder shape were 30–50% higher compared to the conventional prolate spheroid. However, when these values of stroke volume multiplied by heart rate to calculate cardiac output, no significant differences between models emerged because of considerable variability in heart rate. Essentially, the conventional prolate spheroid shape model provides the simplest measurement with lowest variability of stroke volume and cardiac output. However, assessment of heart function—especially if stroke volume is the focus of the study—should consider larval heart shape, with different models being applied on a species-by-species and developmental stage-by-stage basis for best estimation of cardiac output.

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Effects of crude oil on in situ cardiac function in young adult mahi–mahi ( Coryphaena hippurus )

Cited by 74 publications

References 45 publications

Polyaromatic hydrocarbons in pollution: a heart‐breaking matter

Polyaromatic hydrocarbons in pollution: a heart‐breaking matter

Mahi‐mahi (Coryphaena hippurus) life development: morphological, physiological, behavioral and molecular phenotypes

Heart Performance Determination by Visualization in Larval Fishes: Influence of Alternative Models for Heart Shape and Volume

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