Effects of crush and axotomy on oxidative stress and some trace element levels in phrenic nerve of rats

Sayır, Fuat; Kavak, Servet; Meral, İsmail; Demır, Halit; Cengiz, Nurettin; Çobanoğlu, Ufuk

doi:10.1016/j.brainresbull.2011.07.013

Cited by 18 publications

(16 citation statements)

References 33 publications

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“…In our study, the concentration of Cu in the plasma of cancer patients was significantly lower than that of healthy controls. Which is in agreement with Khoshdel et al, while, it is contrary to the finding of Zablocka‐Slowinska et al, Marco et al, and Emre et al Since the copper is a transition active redox metal, it plays an important role in several normal immune function disorders . Where it is bound to numerous enzymes, either, as a cofactor or as an allosteric component .…”

Section: Resultssupporting

confidence: 83%

Determination of trace elements Fe, cu and Zn in the Algerian cancerous plasma using X‐ray fluorescence (XRF)

et al. 2019

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Cancers are among the leading causes of morbidity and mortality in the world.The purpose of this study was to conduct a survey on the effect of minerals on cancer risk in the Algerian population. One hundred and seventy-eight plasma samples were used to analyze the concentrations of iron (Fe), copper (Cu), and zinc (Zn) in cancerous patients and also in healthy subjects using the X-ray florescence technique (XRF). Samples were classified according to the age and gender of the donors. An empirical formula was developed for the concentration of Zinc, Copper and Iron in cancer patients according to the age. The averages iron, copper and zinc concentrations in mg/kg for control and Cancer disease groups were (1493 ± 105; 1496 ± 86), (1172 ± 229; 1078 ± 283) and (1266 ± 202; 1344 ± 208) respectively. The ANOVA One-Way test was applied. For both genders of control and cancer disease groups it shows a significant decrease rate of copper for global and female gender and a significant increase rate of zinc for global and male gender (p < 0.05). The results indicate that the Cu and Zn concentration could show helpful tools for diagnosis and preventive treatment of cancer diseases.

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Section: Resultssupporting

confidence: 83%

Determination of trace elements Fe, cu and Zn in the Algerian cancerous plasma using X‐ray fluorescence (XRF)

et al. 2019

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“…Beside these properties, it is also an essential element for formation of hemoglobulin, myelin, collagen, and melanin. Cu has been suggested to play an important role in several disorders and normal immune function [13,14]. Nayak et al performed a study in 20 patients affected by prostate and colon cancer, at the end of study they found that copper and ceruloplasmin levels were increased significantly in the cancer patients as compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Özgür¹,

Demır²,

Doğan³

et al. 2013

JCT

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Purpose: It is well known that trace elements and heavy metals play a significant role in human health and disease. These elements play an important role in different metabolic pathways of cells and tissues. Trace element deficiency or excess is implicated in the development or progression of some cancers. We present a study which investigates serum/ plasma levels of trace-heavy elements in metastatic colon cancer patients and healthy subjects. Methods: Blood samples were collected from 29 healthy subjects and 40 patients with metastatic colon cancer in Oncology Department of Medical School of Yuzuncu Yil University. In both groups, the serum levels of copper (Cu), magnesium (Mg), lead (Pb), chromium (Cr), zinc (Zn) selenium (Se), manganese (Mn), and cadmium (Cd) were determined. Results: Higher levels of Cu, Mg, Pb, Cr, Zn, Mn and Cd were seen in patients with metastatic colon cancer compared to healthy subjects and these findings were statistically significant (p < 0.05). Se levels were noted to be lower in patients with colon cancer in comparison to healthy subjects and this finding was also statistically significant (p < 0.05). Conclusions: According to our findings there was significant diffence in trace elements and heavy metals levels between healthy subjects and metastatic colon cancer patients. Therefore heavy metal and trace elements may have prognostic significance in complex disorders including colon cancer. However, further comprehensive studies are needed in order to advance our understanding of the relationship between heavy metal and trace elements and their role in cancers.

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“… 64 In axotomied or crushed phrenic nerves, oxidative stress might be directly produced via an increase in lipid peroxidation, and a decrease in antioxidant enzyme activities. 65 After partial optic nerve injury, RGCs undergo secondary death, but it is unclear how these nonviable cells distribute, and which cell death pathways are involved. 66 It has also been demonstrated that oxidative stress spreads from injured axons to surrounding RGC somata via the astrocytic network, which occurs in the early stages of secondary degeneration.…”

Section: Interactions Between Oxidative Stress and Autophagy In Rgcsmentioning

confidence: 99%

Oxidative stress induces autophagy in response to multiple noxious stimuli in retinal ganglion cells

2014

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Retinal ganglion cells (RGCs) are the only afferent neurons that can transmit visual information to the brain. The death of RGCs occurs in the early stages of glaucoma, diabetic retinopathy, and many other retinal diseases. Autophagy is a highly conserved lysosomal pathway, which is crucial for maintaining cellular homeostasis and cell survival under stressful conditions. Research has established that autophagy exists in RGCs after increasing intraocular pressure (IOP), retinal ischemia, optic nerve transection (ONT), axotomy, or optic nerve crush. However, the mechanism responsible for defining how autophagy is induced in RGCs has not been elucidated. Accumulating data has pointed to an essential role of reactive oxygen species (ROS) in the activation of autophagy. RGCs have long axons with comparatively high densities of mitochondria. This makes them more sensitive to energy deficiency and vulnerable to oxidative stress. In this review, we explore the role of oxidative stress in the activation of autophagy in RGCs, and discuss the possible mechanisms that are involved in this process. We aim to provide a more theoretical basis of oxidative stress-induced autophagy, and provide innovative targets for therapeutic intervention in retinopathy.

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Effects of crush and axotomy on oxidative stress and some trace element levels in phrenic nerve of rats

Cited by 18 publications

References 33 publications

Determination of trace elements Fe, cu and Zn in the Algerian cancerous plasma using X‐ray fluorescence (XRF)

Determination of trace elements Fe, cu and Zn in the Algerian cancerous plasma using X‐ray fluorescence (XRF)

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Oxidative stress induces autophagy in response to multiple noxious stimuli in retinal ganglion cells

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