Effects of crustacean hyperglycemic hormone (CHH) on regulation of hemocyte intracellular signaling pathways and phagocytosis in white shrimp Litopenaeus vannamei

Xu, Lijun; Pan, Luqing; Zhang, Xin; Wei, Cun

doi:10.1016/j.fsi.2019.07.051

Cited by 37 publications

(8 citation statements)

References 92 publications

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“…Several reports studying the immunoregulatory effects of CHH in the Pacific white shrimp L. vannamei showed that recombinant CHH increased pathogen clearance and survival rates in pathogen-infected shrimps (82), and elevated total hemocyte count and the phagocytic activity of hemocyte (180). CHH treatment also affected the expression of several immune effector protein genes, including superoxide dismutase, LvRelish, and anti-microbial peptides, suggesting protective roles of CHH through modulating the immune activity of the shrimps (84,180). It would be informative to investigate CHH-modulated immune responses under pathogenic conditions, which are invariantly characterized by significantly higher CHH levels as has been previously reported (79)(80)(81)175).…”

Section: Pathogenesis and Immune Regulation (Chh)mentioning

confidence: 99%

The Crustacean Hyperglycemic Hormone Superfamily: Progress Made in the Past Decade

2020

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Early studies recognizing the importance of the decapod eyestalk in the endocrine regulation of crustacean physiology—molting, metabolism, reproduction, osmotic balance, etc.—helped found the field of crustacean endocrinology. Characterization of putative factors in the eyestalk using distinct functional bioassays ultimately led to the discovery of a group of structurally related and functionally diverse neuropeptides, crustacean hyperglycemic hormone (CHH), molt-inhibiting hormone (MIH), gonad-inhibiting hormone (GIH) or vitellogenesis-inhibiting hormone (VIH), and mandibular organ-inhibiting hormone (MOIH). These peptides, along with the first insect member (ion transport peptide, ITP), constitute the original arthropod members of the crustacean hyperglycemic hormone (CHH) superfamily. The presence of genes encoding the CHH-superfamily peptides across representative ecdysozoan taxa has been established. The objective of this review is to, aside from providing a general framework, highlight the progress made during the past decade or so. The progress includes the widespread identification of the CHH-superfamily peptides, in particular in non-crustaceans, which has reshaped the phylogenetic profile of the superfamily. Novel functions have been attributed to some of the newly identified members, providing exceptional opportunities for understanding the structure-function relationships of these peptides. Functional studies are challenging, especially for the peptides of crustacean and insect species, where they are widely expressed in various tissues and usually pleiotropic. Progress has been made in deciphering the roles of CHH, ITP, and their alternatively spliced counterparts (CHH-L, ITP-L) in the regulation of metabolism and ionic/osmotic hemostasis under (eco)physiological, developmental, or pathological contexts, and of MIH in the stimulation of ovarian maturation, which implicates it as a regulator for coordinating growth (molt) and reproduction. In addition, experimental elucidation of the steric structure and structure-function relationships have given better understanding of the structural basis of the functional diversification and overlapping among these peptides. Finally, an important finding was the first-ever identification of the receptors for this superfamily of peptides, specifically the receptors for ITPs of the silkworm, which will surely give great impetus to the functional study of these peptides for years to come. Studies regarding recent progress are presented and synthesized, and prospective developments remarked upon.

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Section: Pathogenesis and Immune Regulation (Chh)mentioning

confidence: 99%

The Crustacean Hyperglycemic Hormone Superfamily: Progress Made in the Past Decade

2020

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“…Similar variations in the expression of MIH I genes were reported from crustaceans exposed to irregular light/dark cycles, and was induced by ROS stress which led to alterations in the circadian rhythm and arrhythmic moulting [ 56 ]. The CHH gene expression controls the glucose metabolism and involves in maintenance of general physiology in crustaceans [ 57 ]. The over-expression of the CHH gene induced in photoexcited curcumin treatment may contribute to the induction of phagocytosis and stimulation of immune functions in P. monodon.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Photodynamic Antimicrobial Chemotherapy on the Microbiome, Neuroendocrine and Immune System of Crustacean Post Larvae

Anas

Pramodh²,

Sukumaran³

et al. 2022

Toxics

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Photodynamic antimicrobial chemotherapy (PACT), employing a combination of light and natural photosensitizer molecules such as curcumin, has been accepted as a safe modality for removing aquatic pathogens which cause diseases such as cholera in humans and vibriosis in aquatic animals. Curcumin and its photodegradation products are generally considered as safe to animals, but the impact of reactive oxygen species (ROS) generated by these products on the growth and survival of organisms at a cellular level has not been studied in detail. The ROS generated by curcumin on photoexcitation using blue light (λmax 405 nm, 10 mW cm−2) disinfects more than 80% of free-living Vibrio spp. in the rearing water of Penaeus monodon. However, it is less effective against Vibrio spp. colonized inside P. monodon because the carapace of the animal prevents the transmission of more than 70% of light at the 400–450 nm range and thus reduces the formation of ROS. The influence of curcumin and photoexcited curcumin on the microbiome of P. monodon were revealed by nanopore sequencing. The photoexcited curcumin induced irregular expression of genes coding the moult-inhibiting hormone (MIH), Crustacean hyperglycaemic hormone (CHH)), prophenoloxidase (ProPO), and crustin, which indicates toxic effects of ROS generated by photoexcited curcumin on the neuroendocrine and immune systems of crustaceans, which could alter their growth and survival in aquaculture settings. The study proposed the cautious use of photodynamic therapy in aquaculture systems, and care must be taken to avoid photoexcitation when animals are experiencing moulting or environmental stress.

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“…20 In addition, the phagocytosis-related proteins and the phagocytic activity were activated via cGMP-PKG-NF-κB pathway under the high content of CHH. 242 Studies on another neuroendocrine factor, BA, that changes under environmental stress, Xie et al 243 showed that DA might regulate the role of proPO system in haemocytes through PKC-related signalling pathways. Moreover, In conclusion, compared with vertebrates, invertebrates have not evolved an independent nervous system and endocrine system, as well as the immune system is mainly innate immunity.…”

Section: Physico-chemical Factorsmentioning

confidence: 99%

Neuroendocrine‐immune regulation mechanism in crustaceans: A review

Tong

Pan

Zhang

et al. 2021

Reviews in Aquaculture

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With the increase of global population and seafood consumption, aquaculture is becoming more and more important for meeting global seafood demands. In the past decade, aquaculture production increased from 52.5 million tons in 2008 to 82.1 million tons in 2018. The estimated value of aquaculture production increased from USD 98.4 billion in 2008 to USD 250 billion in 2018. 1 Crustaceans contribute to 9.4 (11.4%) million tons of production, worth USD 69.3 billion in 2018. 1 However, disease problems have always been the restricting factor of crustacean culture, and has become the most significant hazard factor, causing substantial economic losses. The outbreak of crustacean diseases results from the invasion of external pathogens, the decline of animal immunity, and environmental stress. In particular, the deterioration of aquaculture environment can inhibit the immune system and increase the susceptibility of

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Effects of crustacean hyperglycemic hormone (CHH) on regulation of hemocyte intracellular signaling pathways and phagocytosis in white shrimp Litopenaeus vannamei

Cited by 37 publications

References 92 publications

The Crustacean Hyperglycemic Hormone Superfamily: Progress Made in the Past Decade

The Crustacean Hyperglycemic Hormone Superfamily: Progress Made in the Past Decade

The Influence of Photodynamic Antimicrobial Chemotherapy on the Microbiome, Neuroendocrine and Immune System of Crustacean Post Larvae

Neuroendocrine‐immune regulation mechanism in crustaceans: A review

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