Effects of Cue-Exposure Treatment on Neural Cue Reactivity in Alcohol Dependence: A Randomized Trial

Vollstädt‐Klein, Sabine; Loeber, Sabine; Kirsch, Peter; Bach, Patrick; Richter, Anne; Bühler, M.; Goltz, Christoph von der; Hermann, Derik; Mann, Karl; Kiefer, Falk

doi:10.1016/j.biopsych.2010.12.016

Cited by 184 publications

(140 citation statements)

References 41 publications

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“…Earlier studies in individuals with alcohol use disorders have implicated the striatum, amygdala and MPFC in reward processing and have linked activation in these areas to craving and approach behaviour. [7][8][9][10][11][12][15][16][17]43 However, to our knowledge, this is the first study to demonstrate that a hyper activation of these reward-associated areas is associated not only with the development of craving, but also with real decisions in favour of alcoholic drinks.…”

Section: Discussionmentioning

confidence: 68%

To drink or not to drink: Harmful drinking is associated with hyperactivation of reward areas rather than hypoactivation of control areas in men

Stuke

Gutwinski

Wiers

et al. 2016

jpn

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IntroductionThe maintenance of harmful alcohol use implies reiterated decisions to consume alcohol in concrete drinking occasions. These decisions are often made despite an intention to quit or reduce alcohol consumption. Although there is quite a large body of evidence on neural responsivity to alcohol cues or neural mechanisms of general decision-making capacities in individuals with alcohol use disorders, the neural processes during real drinking decisions remain largely unclear.Dual-process models of addiction 1,2 state the importance of 2 distinct but interacting systems during decisions for and against alcohol consumption. On the one hand, a reward system (also referred to as an impulsive, motivational, or reflexive system) has been implicated in the immediate emotional assessment of stimuli and automatic (approach) behaviour. On the other hand, a cognitive control system (also referred to as a deliberative or reflective system) that modulates this primary assessment by integration of higher-order considerations, such as long-term effects of a possible decision, has been suggested. In theory, both a hyperactive reward system and an impaired control system may contribute to addictive behaviour. Indeed, behavioural and neuroimaging data suggest alterations in both systems in individuals with substance use disorders.Alcohol-dependent or heavily drinking individuals show subjective craving 3 and automatic approach tendencies 4,5 when confronted with alcoholic drinks, and a substantial body of literature suggests that such addiction-related behaviour is Background:The maintenance of harmful alcohol use can be considered a reiterated decision in favour of alcohol in concrete drinking occasions. These decisions are often made despite an intention to quit or reduce alcohol consumption. We tested if a hyperactive reward system and/or an impaired cognitive control system contribute to such unfavourable decision-making. Methods: In this fMRI study, men with modest to harmful drinking behaviour, which was measured using the Alcohol Use Disorders Identification Test (AUDIT), repeatedly made decisions between alcoholic and nonalcoholic drinks. Based on prior individual ratings, decision pairs were created with an alcoholic decision option considered more desirable but less beneficial by the participant. By correlating AUDIT scores with brain activation during decision-making, we determined areas explicitly related to pro-alcohol decisions in men with greater drinking severity. Results: Thirty-eight men participated in our study. Behaviourally, we found a positive correlation between AUDIT scores and the number of decisions for desired alcoholic drinks compared with beneficial nonalcoholic drinks. The fMRI results show that AUDIT scores were positively associated with activation in areas associated with reward and motivation processing (i.e., ventral striatum, amygdala, medial prefrontal cortex) during decisions favouring a desired, nonbeneficial alcoholic drink. Conversely, we did not find hypoactivation in areas assoc...

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Section: Discussionmentioning

confidence: 68%

To drink or not to drink: Harmful drinking is associated with hyperactivation of reward areas rather than hypoactivation of control areas in men

Stuke

Gutwinski

Wiers

et al. 2016

jpn

View full text Add to dashboard Cite

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“…More specifically, the significant area covered large parts of the retrosplenial cortex [19]. As already mentioned, an association between alcohol cue exposure and increased activity in the PCC has been reported previously [17,18]. …”

Section: Discussionmentioning

confidence: 78%

“…An association between alcohol cue exposure and increased activity in the posterior cingulate cortex (PCC) has been reported previously [17,18]. The results presented here are the second part of a larger functional MRI (fMRI) study using the cue exposure paradigm in alcoholics.…”

Section: Introductionmentioning

confidence: 80%

Impact of Alcohol-Related Video Sequences on Functional MRI in Abstinent Alcoholics

Krienke

Nikesch²,

Spiegelhalder³

et al. 2013

Eur Addict Res

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The object of this study was the identification of brain areas that were significantly more connected than other regions with a previously identified reference region, the posterior cingulate cortex, during the presentation of visual cues in alcoholics. Alcohol-related and neutral video sequences were presented to 30 alcoholics who had been abstinent for at least 4 days. Participants underwent a psychometric assessment before and after the presentation of the video sequences. Functional MRI data were acquired. Psychophysiological interaction analyses were carried out. Participants reported a significant increase in craving and arousal after the presentation of alcohol-related video sequences. The simple contrast alcohol versus neutral was found not to be significantly different in the present study. The brain regions that were found to correlate significantly more with the posterior cingulate cortex under the alcohol-related condition were the inferior parietal lobe, the medial temporal lobe, the inferior frontal gyrus, the postcentral gyrus, and the precuneus. The involvement of these regions in processes of memory, self-control, and self-reflection with a particular focus on alcohol dependence and craving will be discussed.

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“…Se sabe que estas regiones están involucradas en el procesamiento emocional y cognitivo de recompensa, pudiendo conferir una sensibilidad mayor al estrés en los pacientes alcohólicos. Por último, la literatura en pacientes humanos también ha implicado regiones como la ínsula anterior, implicada en el mencionado craving (8), y el córtex cingulado anterior (ACC) (9).…”

Section: Introductionunclassified

Estudio de la conectividad cerebral en dos estados característicos de alcoholismo mediante imagen de resonancia magnética. Aplicación en rata como modelo experimental

Cervera

2018

DOCTUMH

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Effects of Cue-Exposure Treatment on Neural Cue Reactivity in Alcohol Dependence: A Randomized Trial

Cited by 184 publications

References 41 publications

To drink or not to drink: Harmful drinking is associated with hyperactivation of reward areas rather than hypoactivation of control areas in men

To drink or not to drink: Harmful drinking is associated with hyperactivation of reward areas rather than hypoactivation of control areas in men

Impact of Alcohol-Related Video Sequences on Functional MRI in Abstinent Alcoholics

Estudio de la conectividad cerebral en dos estados característicos de alcoholismo mediante imagen de resonancia magnética. Aplicación en rata como modelo experimental

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