Effects of Curcuma longa dietary inclusion against Eimeria spp. in naturally-infected lambs

Cervantes-Valencia, María Eugenia; Alcalá-Canto, Yazmín; Sumano-López, Héctor; Ducoing-Watty, Adriana Margarita; Gutiérrez-Olvera, Lilia

doi:10.1016/j.smallrumres.2015.12.035

Cited by 28 publications

(12 citation statements)

References 76 publications

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“…The use of curcumin, a bioactive agent derived from Curcuma longa rhizomes, has been used in the treatment of humans and animals because of its innumerable benefits, particularly its antimicrobial (Sarkar, De, & Mukhopadhyay, 2016), antioxidant and lipid peroxidation-protecting properties (Akinyemi et al, 2017;Momeni & Eskandari, 2017), in addition to its promotion of growth and performance in animals (Dono, 2013;Jaguezeski et al, 2018). Only in recent years have there been studies evaluating curcumin as an additive in ruminant feed (Cervantes-Valencia, Alcalá-Canto, Sumano-Lopez, Ducoing-Watty, & Gutierrez-Olvera, 2016;Jaguezeski et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

et al. 2019

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The main objective of this study was to evaluate whether the addition of curcumin‐loaded nanocapsules (prepared and characterized) in the diets of dairy sheep improved milk quality. The nanocapsules were prepared using two polymers: poly‐ε‐caprolactone (PCL) and Eudragit L‐100. The nanocapsules contained 0.25 mg/ml (Nano‐Eudragit L‐100) and 2 mg/ml (Nano‐PCL) of curcumin. Dairy sheep were divided into four groups: A (control), B (30 mg free curcumin/kg concentrate), C (3 mg Nano‐PCL/kg concentrate), and D (3 mg Nano‐Eudragit/kg concentrate). We observed that the number of total leukocytes and serum globulin levels were lower in Group D than in the control (Group A) (p < 0.05). Antioxidant capacity against peroxyl radicals (ACAP) and catalase enzymes was elevated in Group D, with consequently reduced lipid peroxidation (LPO; p < 0.05). In milk, there were no differences in production and composition between groups during the experimental period (p > 0.05); however, ACAP increased and LPO decreased in milk. Practical applications Curcumin is a functional molecule with potent antioxidant, anti‐inflammatory, and antimicrobial actions, used frequently and with medical indications in human food. Free curcumin in sheep diets improves milk quality and increases its shelf life. This study showed that curcumin nanocapsules produced from the Eudragit L‐100 polymer potentiated the anti‐inflammatory and antioxidant actions of dairy sheep when used in the diet daily, at doses 10 times lower than that of free curcumin. These positive effects were reflected in higher total antioxidant capacity and lower lipid peroxidation in milk in sheep‐fed curcumin‐loaded Eudragit L‐100 nanocapsules, generating desirable milk properties. In practice, the use of nanotechnology enhances the beneficial effects of curcumin in milk, possibly creating a nutraceutical food desirable to consumers.

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Section: Introductionmentioning

confidence: 99%

Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

et al. 2019

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“…As such, Eimeria- infected animals showed diminished oocysts shedding and less lesions after curcumin treatment (19, 27, 40, 41). More importantly, daily weight gains revealed two-fold higher in curcumin-treated farm animals compared to non-treated controls (28). In addition, curcumin treatments also resulted in improved quality of meat products (prolonged storage stability), most probably due to antioxidant activities of curcumin (42).…”

Section: Discussionmentioning

confidence: 99%

“…In times of increasing resistance of several parasites against synthetic antiparasitic drugs worldwide, which imposes a huge problem in livestock production (14, 15), the application of bioactive plant compounds represent an important alternative measure to control parasitoses (16–18). Therefore, in vitro anti-protozoan effects of curcumin against numerous species have recently been described, i.e., Eimeria tenella, E. bovis, Giardia intestinalis, Plasmodium falciparum, P. berghei, Leishmania spp., Trypanosoma cruzi, T. evansi, Cryptosporidium parvum, Neospora caninum , and Toxoplasma gondii (19–26). In addition, in vivo effects of curcumin treatments were also documented in rabbit and sheep coccidiosis (27, 28).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, in vitro anti-protozoan effects of curcumin against numerous species have recently been described, i.e., Eimeria tenella, E. bovis, Giardia intestinalis, Plasmodium falciparum, P. berghei, Leishmania spp., Trypanosoma cruzi, T. evansi, Cryptosporidium parvum, Neospora caninum , and Toxoplasma gondii (19–26). In addition, in vivo effects of curcumin treatments were also documented in rabbit and sheep coccidiosis (27, 28). Overall, the molecular mechanism of curcumin action is not known so far, but interference with intracellular organelles and cytoskeleton or with cellular metabolism is postulated (29), which might impact on protozoan parasites.…”

Section: Introductionmentioning

confidence: 99%

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Antiparasitic Efficacy of Curcumin Against Besnoitia besnoiti Tachyzoites in vitro

et al. 2019

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Besnoitia besnoiti is the causative agent of bovine besnoitiosis. B. besnoiti infections lead to reduced fertility and productivity in cattle causing high economic losses, not only in Europe, but also in Asia and Africa. Mild to severe clinical signs, such as anasarca, oedema, orchitis, hyperkeratosis, and characteristic skin and mucosal cysts, are due to B. besnoiti tachyzoite and bradyzoite replication in intermediate host tissues. So far, there are no commercially available effective drugs against this parasite. Curcumin, a polyphenolic compound from Curcuma longa rhizome is well-known for its antioxidant, anti-inflammatory, immunomodulatory and also anti-protozoan effects. Hence, the objective of this study was to evaluate the effects of curcumin on viability, motility, invasive capacity, and proliferation of B. besnoiti tachyzoites replicating in primary bovine umbilical vein endothelial cells (BUVEC) in vitro. Functional inhibition assays revealed that curcumin treatments reduce tachyzoite viability and induce lethal effects in up to 57% of tachyzoites (IC50 in 5.93 μM). Referring to general motility, significant dose-dependent effects of curcumin treatments were observed. Interestingly, curcumin treatments only dampened helical gliding and twirling activities whilst longitudinal gliding motility was not significantly affected. In addition, curcumin pretreatments of tachyzoites resulted in a dose-dependent reduction of host cell invasion as detected by infections rates at 1 day p. i. These findings demonstrate feeding cattle with Curcuma longa rhizomes may represent a new strategy for besnoitiosis treatment.

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“…(15) oraz Cervantes-Valencia i wsp. (2). Warto podkreślić, że w przypadku analizy dotyczącej zwierząt młodych problem dotyczy w głównej mierze kokcydiozy, która jest wywoływana przez pierwotniaki z rodzaju Eimeria (3,5,12,17).…”

Section: Wyniki I Omówienieunclassified

Effect of various antiparasitic treatments on the economic value of production in a sheep flock

Junkuszew¹,

Dudko²,

Bojar³

et al. 2017

Medycyna Weterynaryjna

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Our objective was to compare the effects of a conventional antiparasitic chemical drug and a lick block containing plant-based compounds on the economic value of lambs. Ewes and their new-born offspring were allocated among three treatments: a group receiving standard drenching with an albendazole-containing drug, a group supplied with a lick block containing essential oils from 10 plant species having antiparasitic properties, and a control group that was not dewormed. During the experiment, all lambs were given periodic birth weighings at 28, 56, 70 and 100 days of age. The results obtained were the basis for the estimation of the economic value of lambs reared in particular experimental groups of the observed animals. The average price earned for slaughter material in each weight standard was used to calculate the differences between the groups. The current prices were made available by the Regional Association of Sheep and Goat Breeders in Lublin. All lambs (live at 56, 70, 100 and 120 days) were included in calculations of the average value of the animals. In the case of lambs falling within the standard 0 to 12 kg, a value for 0 PLN per kilogram was assumed because of the lack of sales potential. At 56 days, the value of the lambs in the group receiving feed with the addition of essential oils was 11.90% higher than that of the lambs from control group. At 70, 100 and 120 days, the value of those lambs was higher than that of the lambs from control group by 21.13%, 4.99% and 5.51%, respectively. The value of the lambs from the group receiving standard drenching with an albendazole-containing drug was similar to that of the lambs from the undewormed group. The results of the research indicate that it is beneficial to use natural substances in the prevention of parasitic invasion. The use of natural methods to reduce parasitic infestations will reduce the application of chemicals, which is extremely important due to the increasing resistance of parasites and the preferences of consumers, who search for products free of harmful residues of medicinal substances.

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Effects of Curcuma longa dietary inclusion against Eimeria spp. in naturally-infected lambs

Cited by 28 publications

References 76 publications

Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

Antiparasitic Efficacy of Curcumin Against Besnoitia besnoiti Tachyzoites in vitro

Effect of various antiparasitic treatments on the economic value of production in a sheep flock

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