Effects of curcumin and its nanomicelle form on body weight, insulin resistance, adiponectin, and blood parameters of streptozotocin-induced diabetic rats

Dadgar, Hamed; Kermanshahi, Hassan; Jaafari, Mahmoud Reza; Javadmanesh, Ali

doi:10.21203/rs.3.rs-136310/v1

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…16,17 An increase of QUICKI value was also reported in patients with T2DM on a clinical trial after curcumin intake, as an addition to the previously mentioned effect. Findings regarding glycemic indices in our study are in line with Dadgar et al 18 , that has reported a significant suppressing effect of curcumin nano micelles on levels of serum glucose concentration in streptozotocininduced diabetic rats. This report is consistent with the original research results carried out so far, as mentioned by Rivera-Mancia et al 19 , about the utility of curcumin to reduce insulin resistance by targeting the JNK/ IRS pathway that has been tested in several in vivo and in vitro models.…”

Section: Discussionsupporting

confidence: 93%

Effect of Curcumin towards Metabolic Disturbance Parameters in Patient with PCOS: A Systematic Review and Meta-Analysis of Clinical and Preclinical Randomized Controlled Trials

Ekafentie,

Widjanarko,

Yosephine

et al. 2023

Obgynia

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Objective: Polycystic Ovarian Syndrome (PCOS) is a gynecologic and endocrine disorder with metabolic disturbances and infertility as the most common long-term consequences. Curcumin comes up as one of the alternative herbal remedies in PCOS treatment options. This study aimed to investigate the therapeutic effect of curcumin on metabolic disturbance parameters in PCOS patients and PCOS-modeled rats. Method: A systematic search of eligible studies was done using PubMed, Google Scholar, EBSCO-Host, and ProQuest according to the PRISMA 2009 guideline. We further assessed for risk of bias using SYRCLE’s risk of bias tool for preclinical studies and The Cochrane risk of bias assessment tool for the clinical studies. We used Review Manager (version 5.4) with random effect model to obtain a pooled mean difference with 95% CIs. Results: Five preclinical studies and three clinical studies were selected and pooled. The significant decrease in the level of Fasting Plasma Glucose (FPG), Fasting Insulin (FI), lipid profile, and Homeostatic Model of Insulin Resistance (HOMA-IR) value, and a significant increase in Quantitative Insulin-Sensitivity Check Index (QUICKI) value found in preclinical studies. The result for clinical studies showed a significantly decreased HOMA-IR values (SMD=-0.36, p=0.001), FPG level (SMD=-3.32, p=0.0001), Serum Insulin level (SMD=-1.47, p=0.002), and increased QUICKI value (SMD=0.01, p=0.006). Conclusion: Curcumin offers a substantial effect on metabolic disturbance parameters in PCOS patients and could be an alternative promising treatment for PCOS patients in the future.Pengaruh Kurkuma terhadap Parameter Gangguan Metabolik pada Pasien SOPK: Tinjauan Sistematis dan Meta-Analisis Uji Acak Preklinis dan Klinis TerkontrolAbstrakTujuan: Sindrom Ovarian Polikistik (PCOS) merupakan suatu kelainan ginekologi dan endokrin dengan gangguan metabolisme dan infertilitas sebagai konsekuensi jangka panjang yang paling umum ditemukan. Kurkumin muncul sebagai salah satu pengobatan herbal alternatif dalam pilihan terapi PCOS. Penelitian ini bertujuan untuk menyelidiki efek terapeutik kurkumin terhadap parameter gangguan metabolik pada pasien PCOS dan model tikus yang mengalami PCOS.Metode: Penelitian ini dilakukan dengan mencari studi penelitian yang memenuhi syarat menggunakan PubMed, Google Scholar, EBSCO-Host, dan ProQuest mengikuti PRISMA 2009. Penilaian risiko bias studi menggunakan SYRCLE’s Risk of Bias Tool untuk penelitian preklinis dan The Cochrane Risk of Bias Assessment Tool untuk penelitian klinis. Sintesis kuantitatifmenggunakan Review Manager (versi 5.4) dengan random effect model untuk mendapatkan pooled mean difference dengan interval kepercayaan 95%.Hasil: Sebanyak lima studi penelitian preklinis dan tiga studi penelitian klinis memenuhi kriteria. Terdapat penurunan signifikan kadar gula darah puasa, insulin puasa, profil lipid, dan nilai HOMA-IR, serta peningkatan nilai QUICKI pada studi preklinis. Pada studi klinis menunjukkan penurunan nilai HOMA-IR (SMD=-0,36, p=0,001), gula darah puasa (SMD=-3,32, p=0,0001), insulin serum (SMD=-1,47, p=0,002), dan peningkatan nilai QUICKI (SMD=0,01, p=0,006).Kesimpulan: Curcumin dapat memberikan efek terapeutik terhadap parameter gangguan metabolik pasien PCOS dan menjadi salah satu tatalaksana alternatif pasien PCOS di masa depan.Kata kunci: kurkuma; gula darah puasa; sindrom ovarium polikistik.

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Section: Discussionsupporting

confidence: 93%

Effect of Curcumin towards Metabolic Disturbance Parameters in Patient with PCOS: A Systematic Review and Meta-Analysis of Clinical and Preclinical Randomized Controlled Trials

Ekafentie,

Widjanarko,

Yosephine

et al. 2023

Obgynia

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“…Curcumin loaded nanomicelles were targeted to insulin resistant male Wister rats. Curcumin from a nano platform showed significant outcomes (improved insulin resistance) in the treatment of insulin resistance and diabetes mellitus [110]. A recent study on phytochemicals has shown that curcumin is actively involved in decreasing insulin resistance, HbA1c and fasting insulin, leading to effective diabetes management [111].…”

Section: Role Of Curcumin Targeting Inflammation In Diabetes Resistancementioning

confidence: 99%

How Curcumin Targets Inflammatory Mediators in Diabetes: Therapeutic Insights and Possible Solutions

et al. 2022

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Diabetes mellitus is a multifactorial chronic metabolic disorder, characterized by altered metabolism of macro-nutrients, such as fats, proteins, and carbohydrates. Diabetic retinopathy, diabetic cardiomyopathy, diabetic encephalopathy, diabetic periodontitis, and diabetic nephropathy are the prominent complications of diabetes. Inflammatory mediators are primarily responsible for these complications. Curcumin, a polyphenol derived from turmeric, is well known for its anti-oxidant, anti-inflammatory, and anti-apoptotic properties. The regulation of several signaling pathways effectively targets inflammatory mediators in diabetes. Curcumin’s anti-inflammatory and anti-oxidative activities against a wide range of molecular targets have been shown to have therapeutic potential for a variety of chronic inflammatory disorders, including diabetes. Curcumin’s biological examination has shown that it is a powerful anti-oxidant that stops cells from growing by releasing active free thiol groups at the target location. Curcumin is a powerful anti-inflammatory agent that targets inflammatory mediators in diabetes, and its resistant form leads to better therapeutic outcomes in diabetes complications. Moreover, Curcumin is an anti-oxidant and NF-B inhibitor that may be useful in treating diabetes. Curcumin has been shown to inhibit diabetes-related enzymes, such as a-glucosidase, aldose reductase and aldose reductase inhibitors. Through its anti-oxidant and anti-inflammatory effects, and its suppression of vascular endothelial development and nuclear transcription factors, curcumin has the ability to prevent, or reduce, the course of diabetic retinopathy. Curcumin improves insulin sensitivity by suppressing phosphorylation of ERK/JNK in HG-induced insulin-resistant cells and strengthening the PI3K-AKT-GSK3B signaling pathway. In the present article, we aimed to discuss the anti-inflammatory mechanisms of curcumin in diabetes regulated by various molecular signaling pathways.

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Effects of curcumin and its nanomicelle form on body weight, insulin resistance, adiponectin, and blood parameters of streptozotocin-induced diabetic rats

Cited by 2 publications

References 29 publications

Effect of Curcumin towards Metabolic Disturbance Parameters in Patient with PCOS: A Systematic Review and Meta-Analysis of Clinical and Preclinical Randomized Controlled Trials

Effect of Curcumin towards Metabolic Disturbance Parameters in Patient with PCOS: A Systematic Review and Meta-Analysis of Clinical and Preclinical Randomized Controlled Trials

How Curcumin Targets Inflammatory Mediators in Diabetes: Therapeutic Insights and Possible Solutions

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