Effects of curcumin nanodelivery on schizophrenia and glioblastoma

Bulnes, Susana; Picó-Gallardo, Marina; Bengoetxea, Harkaitz; Lafuente, José Vicente

doi:10.1016/bs.irn.2023.05.013

Cited by 1 publication

(1 citation statement)

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“…Furthermore, curcumin also suppresses solar UV ray-induced inflammatory responses by inhibiting the activation of NF-κB and other pro-inflammatory transcription factors [ 2 , 3 ]. Moreover, curcumin is reported for a wide range of medicinal properties, and is also very well tolerated by the human body, even up to 8 g a day, without showing any significant toxicity symptoms [ 4 , 5 , 6 , 7 ]. All these facts have prompted researchers to develop curcumin-based cosmetic formulations, such as sun-screening cream or for general skin care applications [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Preparation of Curcumin-Loaded Pickering Emulsion Using Gelatin–Chitosan Colloidal Particles as Emulsifier for Possible Application as a Bio-Inspired Cosmetic Formulation

Singh,

Bagora,

Nayak

et al. 2024

Pharmaceutics

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In the field of preparing cosmetic formulations, recent advances recommend the usage of excipients derived from biocompatible materials. In this context, the present study aimed to prepare and characterize the curcumin-loaded Pickering emulsion for possible applications in cosmetic formulation. The coconut oil which is often the component of skin care formulations is used as the oily phase. Curcumin, which is well known for absorbing solar radiation, is expected to work synergistically with coconut oil towards improving the sun protection factor (SPF) of the formulation. Additionally, curcumin can also protect the intracellular components through its well-known antioxidant mechanisms. The Pickering emulsion of coconut oil into water was prepared using the composite colloidal particles derived from β-carboxymethyl chitosan (CMC) and Gelatin-A (GA) as the emulsifying agent. The reaction conditions in terms of the weight ratios of CMC and GA, the pH of the reaction medium, the oil volume fraction, and the homogenization speed were optimized to obtain the most stable Pickering emulsion. The obtained systems were physico-chemically characterized by dynamic light scattering, zeta potential, optical microscopy, and rheometric measurements. The final CMC-GA-stabilized emulsion demonstrated an oil droplet size of 100 µm and a SPFspectrophotometric (290–320 nm) value of 8.5 at a curcumin loading of 4 mg/mL. Additionally, the final formulation facilitated the uptake of curcumin into fibroblast (WI26) cells under in vitro conditions. Together, the investigation demonstrates a bio-inspired approach to prepare a curcumin-loaded green Pickering emulsion using biocompatible pharmaceutical grade excipients, which may find utility in cosmetic applications.

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