Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial

Saberi‐Karimian, Maryam; Keshvari, Mahrokh; Ghayour‐Mobarhan, Majid; Salehizadeh, Leila; Rahmani, Sepideh; Behnam, Behzad; Jamialahmadi, Tannaz; Asgary, Sedigheh; Sahebkar, Amirhossein

doi:10.1016/j.ctim.2020.102322

Cited by 109 publications

(81 citation statements)

References 37 publications

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“…Previous studies reported that the antimicrobial activity of CUR in the gut was related to its antiobesity effect (Jin et al, 2018). For example, a study (Saberi-Karimian et al, 2020) reported that CUR (200 mg/kg) could alleviate liver fibrosis in male rats by inhibiting the expression of inflammatory cytokines such as TNF-α, IL-6, and MCP-1 and eventually prevent the development and progression of obesity-related diseases. Sun et al (2018) also demonstrated that MET exerted its hyperglycemia-lowering effect by altering the community of gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

The Therapeutic Efficacy of Curcumin vs. Metformin in Modulating the Gut Microbiota in NAFLD Rats: A Comparative Study

Yao

Gao

et al. 2021

Front. Microbiol.

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Structural disruption of gut microbiota is closely related to the occurrence of non-alcoholic fatty liver disease (NAFLD). Previous research has demonstrated that both curcumin (CUR) and metformin (MET) have a therapeutic effect against NAFLD and play a role in modulating the gut microbiota. However, there is a lack of direct comparison between the two medications in terms of the therapeutic efficacy and the regulatory effect on gut microbiota. In this study, we administered either CUR or MET to rats with high-fat diet (HFD)-induced obesity to observe changes in body parameters, biochemical parameters, liver, and ileum pathology and gut microbiota, and used next generation sequencing and multivariate analysis to evaluate the structural changes of gut microbiota in a NAFLD rat model before and after CUR and MET intervention. It was found that both CUR and MET attenuated hepatic ectopic fat deposition, alleviated inflammatory factors, and improved intestinal barrier integrity in HFD-fed rats. More importantly, CUR and MET reduced the Firmicutes/Bacteroidetes ratio and reverted the composition of the HFD-disrupted gut microbiota. Both CUR and MET treatments effectively modified the gut microbiome, enriched the abundance of beneficial bacteria and reduced opportunistic pathogens in obese rats. The abundance of Butyricicoccus was increased while the abundance of Dorea was decreased in HFD + CUR group. Besides, some beneficial bacteria such as Prevotella were increased in MET-treated animals. Spearman’s correlation analysis showed that Helicobacter, Akkermansia, Desulfovibrio, Romboutsia, Corynebacterium, Lactobacillus, Ruminococcaceae_unclassified, Lachnospiraceae_unclassified, and Clostridiales_unclassified showed significantly positive correlations with TG, TC, LDL-C, GLU, IL-6, IL-1β, and TNF-α, and negative correlations with HDL-C (both p < 0.05). However, Prevotella and Stomatobaculum showed an opposite trend. In summary, CUR and MET showed similar effects in alleviating hepatic steatosis, improving intestinal barrier integrity and modulating gut microbiota in HFD-induced obesity rats, and therefore may prove to be a novel adjunctive therapy for NAFLD.

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Section: Discussionmentioning

confidence: 99%

The Therapeutic Efficacy of Curcumin vs. Metformin in Modulating the Gut Microbiota in NAFLD Rats: A Comparative Study

Yao

Gao

et al. 2021

Front. Microbiol.

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“…The modulation of cytokines linked with NAFLD and its connected inflammation has become a new focus of research. Circulating levels of TNF- α , IL-6, and others in NAFLD have been reported in literature [ 2 , 38 – 40 ].…”

Section: Discussionmentioning

confidence: 99%

Anti‐inflammatory Mechanism of Ruzu Bitters on Diet‐Induced Nonalcoholic Fatty Liver Disease in Male Wistar Rats

Ogunlana

Adekunbi

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Nonalcoholic fatty liver disease (NAFLD) has become notorious globally. Increasingly emerging evidence shows that NAFLD is strongly associated with inflammation, with proinflammatory cytokines such as interleukin-2 (IL-2), interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α) playing a vital role in its progression. In this work, an attempt was made to verify the anti-inflammatory activity of Ruzu herbal bitters (RHB), an antiobesity medicinal concoction, on NAFLD induced by a high-fat diet (HFD) in albino Wistar rats. Twenty-five (25) rats were divided into five groups as follows: Group 1, the normal control, was maintained on standard rat chow and received normal saline (1 ml/kg body weight (BW)/day) for twelve weeks. The other groups were maintained on HFD for twelve weeks. Thereafter, groups 2–5 were treated with pioglitazone (4 mg/kg BW/day), RHB (0.6 ml/kg BW/day), normal saline (1 ml/kg BW/day), and fenofibrate (10 mg/kg BW/day), respectively. The animals were sacrificed after the experimental period. Biochemical indicators of oxidative stress and inflammation were assayed in the liver according to standard methods. The histological features of the liver were also compared to assess liver damage. RHB significantly (p<0.05) reduced body weight and liver index, inhibited oxidative stress, boosted antioxidant enzymes by increasing the activity and level of SOD and GSH, reduced proinflammatory markers (IL-2, IL-6, TNF-α), and reversed histological alterations induced by NAFLD in rat liver. In conclusion, the anti-inflammatory activity of RHB in the prevention of NAFLD in rats has been confirmed.

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“…Besides, the intake of 70 mg per day of curcumin for 8 weeks significantly reduced fatty liver in NAFLD patients, accompanied by improving the serum levels of liver enzymes, lipid profiles, glucose, and glycated hemoglobin [160]. Moreover, a clinical trial based on 55 subjects demonstrated that the supplementation of 500 mg per day of curcumin decreased the serum levels of inflammatory cytokines (like TNF-α and interleukins) in NAFLD patients [161]. Furthermore, a randomized, double-blind, placebo-controlled study based on 58 NAFLD patients showed that curcumin could alleviate NAFLD by regulating amino acid metabolism, tricarboxylic acid cycle, bile acid metabolism, and gut microbiota [162].…”

Section: Clinical Trials Of Plant-based Foods and Their Bioactive Commentioning

confidence: 97%

Plant‐Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

Gan

Shang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Fatty liver disease (FLD), including nonalcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD), is a serious chronic metabolic disease that affects a wide range of people. Lipid accumulation accompanied by oxidative stress and inflammation in the liver is the most important pathogenesis of FLD. The plant-based, high-fiber, and low-fat diet has been recommended to manage FLD for a long time. This review discusses the current state of the art into the effects, mechanisms, and clinical application of plant-based foods in NAFLD and AFLD, with highlighting related molecular mechanisms. Epidemiological evidence revealed that the consumption of several plant-based foods was beneficial to alleviating FLD. Further experimental studies found out that fruits, spices, teas, coffee, and other plants, as well as their bioactive compounds, such as resveratrol, anthocyanin, curcumin, and tea polyphenols, could alleviate FLD by ameliorating hepatic steatosis, oxidative stress, inflammation, gut dysbiosis, and apoptosis, as well as regulating autophagy and ethanol metabolism. More importantly, clinical trials confirmed the beneficial effects of plant-based foods on patients with fatty liver. However, several issues need to be further studied especially the safety and effective doses of plant-based foods and their bioactive compounds. Overall, certain plant-based foods are promising natural sources of bioactive compounds to prevent and alleviate fatty liver disease.

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Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial

Cited by 109 publications

References 37 publications

The Therapeutic Efficacy of Curcumin vs. Metformin in Modulating the Gut Microbiota in NAFLD Rats: A Comparative Study

The Therapeutic Efficacy of Curcumin vs. Metformin in Modulating the Gut Microbiota in NAFLD Rats: A Comparative Study

Anti‐inflammatory Mechanism of Ruzu Bitters on Diet‐Induced Nonalcoholic Fatty Liver Disease in Male Wistar Rats

Plant‐Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

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