Effects of current parenteral nutrition treatment on health-related quality of life, physical function, nutritional status, survival and adverse events exclusively in patients with advanced cancer: A systematic literature review

Abstract

Background:The aim was to evaluate the effects of current parenteral nutrition (PN) treatment on clinical outcomes in patients with advanced cancer. Methods:This review was conducted according to the PRISMA guidelines (PROSPERO ID: 4201707915).Results: Two underpowered randomized controlled trials and six observational studies were retrieved (n=894 patients). Health-related quality of life and physical function may improve during anti-neoplastic treatment in who PN treatment is the only feeding opportunity, but not necessarily in patients able to feed enterally. Nutritional status may improve in patients regardless of anti-neoplastic treatment and gastrointestinal function. PN treatment was neither superior to fluid in terminal patients nor to dietary counselling in patients able to feed enterally in regards to survival. The total incidence of adverse events was low. Conclusion:Current PN treatment in patients with advanced cancer is understudied and the level of evidence is weak.

Cancer cachexia in adult patients: ESMO Clinical Practice Guidelines☆

“… 67 Another systematic review found that PN in patients with advanced cancer was understudied and that the level of evidence was weak. 68 The PS and Glasgow Prognostic Score impact strongly on survival in patients with advanced cancer receiving home PN. 69 From this, it has been suggested that PN should be avoided if the ECOG/WHO PS is 3 or 4.…”

In Reply: Randomized Studies Are Needed to Improve Knowledge of Nutritional Interventions for Advanced Cancer Patients

“…A qualitative study among patients with cancer with CIF showed they had a favorable perception of the impact of PN [7]. Previous studies assessing QoL with validated tools were longitudinal, without randomization, entailing a major risk of bias, as QoL improvements could result from the efficacy of anticancer treatments [8][9][10][11][12]. There is another randomized study that was similar to ours, in the sense that the population included patients with advanced cancer with a functional digestive tract receiving PN.…”

Meaning of Receiving Artificial Nutritional Support in People in the Postoperative Period of Abdominal Surgery

“…Thus, it i show artificial nutritional support provides the nutritional elements fundamental to recover strength and movement. Tobberup et al,( 20 ) found in a systematic review and meta-analyses, a prospective randomized controlled study that evidenced positive changes in physical performance in the six-minute walk test in patients assigned randomly to receive parenteral nutrition.…”