pharmaceutical-sciences 2020
DOI: 10.36468/pharmaceutical-sciences.spl.1
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Effects of Cyathula officinalis Kuan Extracts on Hypertension-induced Renal Vascular Remodeling by Inhibiting the Expression of ALD, Renin, Ang II and the Activation of Erk1/2 and P38 Signaling Pathways: A Mechanistic Study

Abstract: Jiajing et al.: Effects of Cyathula officinalis Kuan Extracts on Hypertension-induced Renal Vascular Remodelling The aim of this study was to investigate the role of the extracts of Cyathula officinalis Kuan on blood pressure in spontaneously hypertensive rats and the possible mechanisms involved. Blood pressure was recorded, renal vascular remodelling was visualized through haematoxylin and eosin staining and the expression of aldosterone, renin and angiotensin II in serum and kidney of spontaneously hyperten… Show more

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“…p38 and MAPK pathways also play a crucial role in extracellular matrix deposition and cell proliferation during hypertensive cardiovascular remodeling (Jing et al, 2011;Jiajing et al, 2020). ERK represents MAPK and is involved in the growth and proliferation of VSMC.…”
Section: Angiotensin II In Cardiac Remodelingmentioning
confidence: 99%
“…p38 and MAPK pathways also play a crucial role in extracellular matrix deposition and cell proliferation during hypertensive cardiovascular remodeling (Jing et al, 2011;Jiajing et al, 2020). ERK represents MAPK and is involved in the growth and proliferation of VSMC.…”
Section: Angiotensin II In Cardiac Remodelingmentioning
confidence: 99%