Effects of cyclin D1 (CCND1) polymorphism on susceptibility to lung cancer in a North Indian population

Cyclin D1 Pro241Pro (CCND1-G870A) Polymorphism Is Associated with Increased Cancer Risk in Human Populations: A Meta-Analysis

“…This trend of increasing susceptibility with increasing presence of the A allele has been also reported in various cancer types (28,56,61,65).…”

Investigation of <em>cyclin D1</em> rs9344 G&gt;A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects

“…The CCND1 rs9344, a G to A polymorphism at nucleotide 870 in exon 4, increases the frequency of alternate splicing. Results of prior studies showed that the A allele of CCND1 rs9344 G>A resulted in an increasing level of mRNA (transcript-b) encoding CCND1 protein with an altered C-terminal domain 8,9. Results of some epidemiologic studies demonstrated that CCND1 rs9344 G>A polymorphism might confer CRC risk 10–18.…”

Effects of the Cyclin D1 Polymorphism on Lung Cancer Risk - a Meta-analysis

“…The CCND1 gene has a G to A polymorphism (G870A) at codon 242 in exon 4, which increases the frequency of alternative splicing, leading to an altered protein that does not contain the sequence involved in protein turnover and then has a longer half-life (Knudsen et al, 2006). To date, many epidemiological studies have been conducted to explore the relationship between the CCND1 G870A polymorphism and lung cancer risk (Qiuling et al, 2003;Gautschi et al, 2006;Hung et al, 2006;Sobti et al, 2006;Hsia et al, 2011). However, the findings were inclusive, partially due to the possible small effect of the polymorphism on lung cancer risk and the relatively small sample size in each of published studies.…”

“…A total of 10 case-control studies with a total of 10, 548 subjects on the association between CCND1 G870A polymorphism and lung cancer risk were included for this meta-analysis (Qiuling et al, 2003;Wang et al, 2003;Buch et al, 2005;Gautschi et al, 2006;Hung et al, 2006;Sobti et al, 2006;Wang et al, 2007;Wang et al, 2008;Li et al, 2009;Hsia et al, 2011). There were four studies of European population (Buch et al, 2005;Gautschi et al, 2006;Hung et al, 2006;Wang et al, 2007), five studies of Asians (Qiuling et al, 2003;Wang et al, 2003;Wang et al, 2008;Li et al, 2009;Hsia et al, 2011) and one study of mixed population (Sobti et al, 2006).…”

“…There were four studies of European population (Buch et al, 2005;Gautschi et al, 2006;Hung et al, 2006;Wang et al, 2007), five studies of Asians (Qiuling et al, 2003;Wang et al, 2003;Wang et al, 2008;Li et al, 2009;Hsia et al, 2011) and one study of mixed population (Sobti et al, 2006). There were about 80.0% studies using the classic PCR-RFLP assay to genotype the CCND1 G870A polymorphism.…”