Effects of cyclo (his–pro) plus zinc on glucose metabolism in genetically diabetic obese mice

Hwang, In-Kyung; Go, Vay Liang W.; Harris, Diane M.; Yip, Ian; Kang, Kai; Song, Min-Ae

doi:10.1046/j.1463-1326.2003.00281.x

Cited by 30 publications

(27 citation statements)

References 52 publications

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“…Cyclo-Z is the only agent able to increase intracellular IDE. In our studies [77], [78] of Cyclo-Z treatment of genetically T2D G-K rats and obese ob/ob mice, plasma insulin levels decreased, while blood glucose decreased and insulin sensitivity increased. Therefore, we conclude that Cyclo-Z treatment increases cellular IDE and improves insulin sensitivity of diabetic rodents.…”

Section: Discussionsupporting

confidence: 47%

Metabolic relationship between diabetes and Alzheimer's Disease affected by Cyclo(His-Pro) plus zinc treatment

et al. 2017

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BackgroundAssociation of Alzheimer's Disease (AD) with Type 2 Diabetes (T2D) has been well established. Cyclo(His-Pro) plus zinc (Cyclo-Z) treatment ameliorated diabetes in rats and similar improvements have been seen in human patients. Treatment of amyloid precursor protein (APP) transgenic mice with Cyclo-Z exhibited memory improvements and significantly reduced Aβ-40 and Aβ-42 protein levels in the brain tissues of the mice.Scope of reviewMetabolic relationship between AD and T2D will be described with particular attention to insulin sensitivity and Aβ degradation in brain and plasma tissues. Mechanistic effect of insulin degrading enzyme (IDE) in decreasing blood glucose and brain Aβ levels will be elucidated. Cyclo-Z effects on these biochemical parameters will be discussed.Major conclusionStimulation of IDE synthesis is effective for the clinical treatment of metabolic diseases including AD and T2D.General significanceCyclo-Z might be the effective treatment of AD and T2D by stimulating IDE synthesis.

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Section: Discussionsupporting

confidence: 47%

Metabolic relationship between diabetes and Alzheimer's Disease affected by Cyclo(His-Pro) plus zinc treatment

et al. 2017

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“…This phenomenon suggests that CHP plus zinc treatment improves insulin sensitivity and plasma insulin levels are low in untreated hyperglycemic rats because prolonged hyperglycemia blocks insulin secretion from pancreatic beta cells. The similar decrease of plasma insulin levels were also observed in ob/ob mice with zinc treatment [85].…”

Section: Plasma Insulin Level Changes By Zc Treatmentsupporting

confidence: 80%

“…Additionally, intraventricular administration of CHP has been shown to significantly reduced water intake [115]. We also found decreased water intake in older G-K and S-D rats after ZC treatment [85,86]. Young rats showed no difference in water consumption regardless of ZC addition to drinking water.…”

Section: Mechanism Of Improving Body Weight Controlsupporting

confidence: 55%

Prevention and Treatment of Obesity and Diabetes and their Related Complications

Song¹

2014

J Mol Genet Med

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“…포도당 주입 후 혈중 CHP가 증가하는 것으로 보아 CHP가 당뇨에서 혈당과 관련된 작용이 제안되어 있 고, 아연과 함께 투여 시 당뇨 모델 쥐에서 인슐린 민감성 (insulin sensitivity) 및 포도당 제거율 (glucose clearance) 을 유의하게 향상시킨다고 보고되었고, 또한 CHP는 중추 신경에서 도파민 기전과 관련되어 있으며 렙틴과 유사한 작 용을 한다 [15,16] …”

Section: 서론unclassified

Enhancement of Cyclo-His-Pro (CHP) Content from Soybean Fermented with Bacillus amyloliquefaciens CHP-12 and Its Anti-diabetic Effect

나경수¹,

최장원²

2011

KSBB Journal

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1) To enhance cyclo-His-Pro (CHP) content, soybean hydrolysate was obtained using the strains isolated from Chungkukjang and further purified by various purification steps. First, twenty two strains were screened from Chungkukjang containing high level of CHP. Among them, the strain No. 12, which showed higher productivity of CHP from soybean ferment and have homologous sequence with 16S rDNA of Bacillus amyloliquefaciens, was named B. amyloliquefaciens CHP-12. Through various purification processes, CHP was concentrated from soybean ferment using ultrafiltration, which showed the best efficiency of CHP production, with the yield (71.3%) and CHP content (2.14 mg/g). Moreover, when glucose tolerance test was performed in Type I Sprague-Dawley rat induced by streptozotocin using the soybean ferments [0.5 g soybean ferment/kg body weight (CHP-0.5 group)] and 1.0 g soybean ferment/kg body weight (CHP-1.0 group), there were significant differences in glucose levels between diabetes-control group (265.3 mg/dL) and soybean ferment-treated groups (CHP-0.

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Effects of cyclo (his–pro) plus zinc on glucose metabolism in genetically diabetic obese mice

Abstract: CZH is effective in decreasing blood glucose concentrations in genetically obese (ob/ob), type 2 diabetic mice. These data support our working hypothesis that CZH may be an important anti-hyperglycaemic agent.

Cited by 30 publications

References 52 publications

Metabolic relationship between diabetes and Alzheimer's Disease affected by Cyclo(His-Pro) plus zinc treatment

Metabolic relationship between diabetes and Alzheimer's Disease affected by Cyclo(His-Pro) plus zinc treatment

Prevention and Treatment of Obesity and Diabetes and their Related Complications

Enhancement of Cyclo-His-Pro (CHP) Content from Soybean Fermented with Bacillus amyloliquefaciens CHP-12 and Its Anti-diabetic Effect

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