Effects of Cyclopropenoid Fatty Acids (Baobab Seed Oil) on the Fatty Acid Profile of Lipids From Different Tissues in the Rat

Abstract

Rats were fed for 8 weeks a diet containing either Baobab seed oil (FBO) rich in cyclopropenoid fatty acids (CPFA) or heated oil (HBO) devoid of CPFA. In FBO rats, compared to controls (CO), the monounsaturated fatty acid content of adipose tissue lipids, liver triacylglycerols, liver and adrenal cholesteryl esters and liver, kidney, adrenal phospholipids were highly decreased to the benefit of saturated fatty acid content. In cholesteryl esters and phospholipids, the arachidonic acid (20:4 n‐6) content was markedly decreased, especially in adrenals. In adrenal cholesteryl esters, adrenic acid (22:4 n‐6) content was decreased more than its precursor. The effects of HBO on the tissue lipid fatty acid profile were practically absent. It is concluded that inhibition of fatty acid desaturation by CPFA previously demonstrated in vitro, was reflected in vivo in tissue lipid fatty acid composition.

Inhibition of stearoyl CoA desaturase activity induces hypercholesterolemia in the cholesterol-fed hamster

“…Previous studies have been inconclusive as to the effect of cyclopropenoid fatty acids on the activity of other fatty acid desaturases. Although it was originally suggested that they had no effect on D6 desaturase activity (19), subsequent studies have questioned this (21,22). In the present study, there was a small increase in hepatic C18:2 associated with SO feeding.…”

A Quantitative Method for the Determination of Cyclopropenoid Fatty Acids in Cottonseed, Cottonseed Meal, and Cottonseed Oil (Gossypium hirsutum) by High-Performance Liquid Chromatography

“…It has been suggested that they play both antifungal () and antifeedant () roles. The presence of these acids can interfere with fatty acid desaturases in animals that include cottonseed products in their diet ( − ). In poultry, inclusion of cottonseed products in feed causes discoloration of the egg yolk ( , ).…”