Effects of cyclosporine on renal function in psoriasis patients

A 24-week randomized clinical trial investigating the efficacy and safety of two doses of etanercept in nail psoriasis

“…ETN was well tolerated with no unexpected safety findings. 12 Antitumour necrosis factor (anti-TNF) biologic agents have improved outcomes in patients with moderate-to-severe plaque psoriasis, [13][14][15][16][17] and evidence has recently emerged showing that anti-TNFs are also effective for treating nail psoriasis. Nail psoriasis is a chronic disease present in up to 50% of patients with psoriasis.…”

“…10,11 Ciclosporin has been associated with some improvement in nail psoriasis but its long-term use has been associated with renal dysfunction. 12 Antitumour necrosis factor (anti-TNF) biologic agents have improved outcomes in patients with moderate-to-severe plaque psoriasis, [13][14][15][16][17] and evidence has recently emerged showing that anti-TNFs are also effective for treating nail psoriasis. 8,15,[18][19][20][21][22][23][24][25][26][27][28][29] Nonetheless, to date no randomized, blinded, clinical study has been specifically designed to investigate the effect of anti-TNFs in this indication.…”

“…In addition, there is no substantial evidence of the efficacy of topical treatments or methotrexate, and limited evidence of efficacy with retinoids and ciclosporin 10,11 . Ciclosporin has been associated with some improvement in nail psoriasis but its long‐term use has been associated with renal dysfunction 12 …”