Effects of Cynara scolymus L. on glycemic indices:A systematic review and meta-analysis of randomized clinical trials

Jalili, Cyrus; Moradi, Sajjad; Babaei, Atefeh; Boozari, Behnoosh; Asbaghi, Omid; Lazaridi, Anastasia-Viktoria; Kermani, Mohammad Ali Hojjati; Miraghajani, Maryam

doi:10.1016/j.ctim.2020.102496

Cited by 12 publications

(9 citation statements)

References 53 publications

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“…Jalili et al (2020) have suggested that the administration of artichoke products can significantly reduce FBS. However, other glycemic indices such as fasting insulin, HOMA-IR, and HbA 1c did not show significant changes after the administration of artichoke and its products.…”

Section: Discussionmentioning

confidence: 99%

Effect of Cynara scolymus L. on Cardiometabolic Outcomes: An Updated Meta-analysis of Randomized Controlled Trials and Meta-regression

Phimarn,

Sungthong,

Wichiyo

2024

Pharmacognosy Magazine

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Background: Artichoke ( Cynara scolymus L.) has the potential to treat diabetes, dyslipidemia, hypertension, and obesity. However, the evidence from previous studies is not consistent. Objectives: This meta-analysis evaluated the efficacy of products derived from artichokes on blood glucose, lipid level, blood pressure, and anthropometric parameters. Methodology: The literature was reviewed via international databases (PubMed, ScienceDirect, and Scopus). A total of 21 RCTs with high quality, assessed by the Cochrane risk-of-bias tool, were included. Results: Artichoke was linked to a significant reduction in fasting blood sugar (FBS) (WMD: −3.76 mg/dL: 95%CI −7.31, −0.22), insulin level (WMD: −1.35 mIU/L: 95%CI −2.29, −0.41), and HOMA-IR (WMD: −1.00: 95%CI −1.95, −0.06). Similar results were observed for LDL-c (WMD: −12.94 mg/dL: 95%CI −18.02, −7.87), total cholesterol (TC) (WMD: −19.64 mg/dL: 95%CI −23.94, −15.35), and triglyceride (TG) (WMD: −13.36 mg/dL: 95%CI −19.06, −7.66). Moreover, participants who administered artichoke experienced a significant reduction in SBP (WMD: −1.59 mmHg: 95%CI −3.02, −0.16), body weight (BW) (WMD: −1.17 kg: 95%CI −1.75, −0.60), and BMI (WMD: −0.30 kg/m2: 95%CI −3.02, −0.16). Conclusion: Artichoke may improve blood glucose, lipid profile, blood pressure, and anthropometric parameters. A large, well-designed RCT and head-to-head comparison using a standardized preparation of artichoke will provide definitive data on specific participants.

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Section: Discussionmentioning

confidence: 99%

Effect of Cynara scolymus L. on Cardiometabolic Outcomes: An Updated Meta-analysis of Randomized Controlled Trials and Meta-regression

Phimarn,

Sungthong,

Wichiyo

2024

Pharmacognosy Magazine

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“…Preceding meta-analysis showed that artichoke supplementation was associated with a significant reduction in both total and low-density lipoprotein cholesterol, without an effect on either triglycerides or high-density lipoprotein cholesterol levels [ 32 ]. In addition, other systematic reviews evaluating the effect of artichoke supplementation on anthropometric and glycemic indices showed the promising effect of artichoke extract on fasting blood glucose and waist circumference but without any effects on other factors [ 33 34 ]. To our knowledge, this systematic review and meta-analysis evaluated the effect of artichoke supplementation on blood pressure for the first time.…”

Section: Discussionmentioning

confidence: 99%

Anti-hypertensive Effects of Artichoke Supplementation in Adults: A Systematic Review and Dose-response Meta-analysis of Randomized Controlled Trials

et al. 2022

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Despite controversies, no earlier study has systematically summarized findings from earlier studies on the effect of artichoke supplementation on blood pressure. Therefore, current systematic review and meta-analysis was done on the effect of artichoke supplementation on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in adults. Five databases were searched from inception to January 2022 using relevant keywords. All randomized clinical trials investigating the impact of oral artichoke supplementation on any of the blood pressure parameters including SBP or/and DBP were included. Out of 1,507 citations, 7 trials that enrolled 472 subjects were included. Artichoke supplementation resulted in significant reduction in SBP (weighted mean difference [WMD], −2.01 mmHg; 95% confidence interval [CI], −3.78, −0.24; p = 0.026) and DBP (WMD, −1.45 mmHg; 95% CI, −2.81, −0.08; p = 0.038). Greater effects on SBP were detected in trials using ≤ 500 mg artichoke, lasted > 8 weeks, participants aged < 50 years’ old and sample size ≤ 70. There was also a similar impact of artichoke on DBP. However, significant non-linear associations were found between artichoke supplementation dosage and study duration with both SBP (for dosage: p non-linearity = 0.002, for duration: p non-linearity = 0.016) and DBP (for dosage: p non-linearity = 0.005, for duration: p non-linearity = 0.003). We found a significant reduction in both SBP and DBP following artichoke supplementation in adults. It could be proposed as a hypotensive supplement in hypertension management.

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“…Der Taillenumfang hatte sich um etwa 1 cm verringert, ohne dass Gewicht und BMI beeinflusst wurden [14]. Ebenso hatte der Nüchtern-Blutzucker um 5 mg/dl abgenommen, ohne Beeinflussung der Nüchtern-Insulinkonzentration, der HOMA-Insulinresistenz und des HbA1c [16]. Für eine konkrete Schlussfolgerung sind weitere Studien mit einem konfirmatorischen Design und längerer Studiendauer erforderlich.…”

Section: Tagesdosis (Td)unclassified

Artischocke – Gemüsepflanze mit potenter Heilkraft

Chrubasik‐Hausmann¹

2021

Zeitschrift für Komplementärmedizin

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Effects of Cynara scolymus L. on glycemic indices:A systematic review and meta-analysis of randomized clinical trials

Cited by 12 publications

References 53 publications

Effect of Cynara scolymus L. on Cardiometabolic Outcomes: An Updated Meta-analysis of Randomized Controlled Trials and Meta-regression

Effect of Cynara scolymus L. on Cardiometabolic Outcomes: An Updated Meta-analysis of Randomized Controlled Trials and Meta-regression

Anti-hypertensive Effects of Artichoke Supplementation in Adults: A Systematic Review and Dose-response Meta-analysis of Randomized Controlled Trials

Artischocke – Gemüsepflanze mit potenter Heilkraft

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