Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial

Abstract

BackgroundThe effects of probiotic Bifidobacterium animalis subsp. lactis CECT 8145 (Ba8145) and those of its heat-killed form (h-k Ba8145) on human anthropometric adiposity biomarkers are unknown.ObjectiveTo assess the effect of Ba8145 and h-k Ba8145 ingestion on anthropometric adiposity biomarkers.DesignRandomized, parallel, double-blind, placebo-controlled trial with abdominally obese individuals. Participants (n = 135) consumed 1 capsule/day containing 1010 colony forming unit (CFU) of Ba8145, 1010 CFU of h-k Ba8145, or placebo (maltodextrin) for 3 months.ResultsBa8145 ingestion decreased waist circumference, waist circumference/height ratio, and Conicity index (P < 0.05) versus its baseline. Changes versus the placebo group reached significance (P < 0.05) after the h-k Ba8145 treatment. Ba8145 decreased the body mass index compared with baseline and placebo group (P < 0.05). The decrease in visceral fat area after Ba8145 treatments reached significance (P < 0.05) only after h-k Ba8145. When analyses by gender were performed, significance remained only for women. Diastolic blood pressure and HOMA index decreased (P < 0.05) after h-k Ba8145. Gut microbiome analyses showed an increase in Akkermansia spp. after Ba8145 treatment, particularly in the live form, which was inversely related to weight (P = 0.003).ConclusionsIn abdominally obese individuals, consumption of Ba8145, both as viable and mainly as heat-killed cells, improves anthropometric adiposity biomarkers, particularly in women. An increase in the gut Akkermansia genus appears as a possible mechanism involved. Our results support Ba8145 probiotic as a complementary strategy in obesity management.

Daily Intake of Paraprobiotic Lactobacillus amylovorus CP1563 Improves Pre-Obese Conditions and Affects the Gut Microbial Community in Healthy Pre-Obese Subjects: A Double-Blind, Randomized, Placebo-Controlled Study

“…These results suggested that fragmented CP1563 reduced abdominal fat area, body weight, and BMI in pre-obese subjects. Several human clinical trials showed an anti-obesity effect of the intake of paraprobiotics [25][26][27]. The anti-obesity effect of fragmented CP1563 in this study supported the results of a previous study, which showed the anti-obesity effect of fragmented CP1563 [30].…”

“…Few findings have focused on the effects of the oral intake of paraprobiotics on the gut microbial community in obesity prevention [26,27]. In addition, there is no evidence about the effects of fragmented CP1563 on the gut microbial community.…”

“…Recent studies indicated that paraprobiotics such as Lactobacillus paracasei MCC1849 and Enterococcus faecalis EC-12 were useful for human health, especially with regard to their immunomodulatory effects [23,24]. Furthermore, paraprobiotics have been shown to have anti-obesity effects in human clinical studies [25][26][27].…”

Microbial Medicine: Prebiotic and Probiotic Functional Foods to Target Obesity and Metabolic Syndrome

“…Overall, these and other human clinical trials in both children [158] and adults [159,160] demonstrate that probiotic supplementation with various species of Bifidobacterium, Lactobacillus and other select taxa, either in isolation or as blended probiotics, elicit positive effects on obesity and associated metabolic pathophysiology. However, as aforementioned these results are highly dependent on the strains under study, the dosage used, and the duration of the intervention.…”

Investigation the Relation Between the Consumption of Probiotic and Prebiotic Foods and Obesity Among Adults, Living in A District in İstanbul

“…25,26 Elde edilen veriler ışığında, probiyotik bakterilerin diyetle tüketiminin anti inflamasyon ve geçirgenliği koruyucu mekanizmaları aktifleştiren etkileri sayesinde abdominal obezitenin azalmasına katkı sağlayabileceği öngörülmüştür, ancak Kadooka ve ark.nın yaptığı çalışmada, direkt bir etki saptanamadığı gibi, olumlu etkinin tüketimin kesilmesiyle birlikte negatif yönde ilerlediği kaydedilmiştir. 27,26 Bu çalışmada elde edilen veriler neticesinde toplumda genel olarak probiyotik ve prebiyotikler hakkında bilgi düzeylerinin diğer çalışmalarda elde edilen sonuçlara kıyasla daha düşük olduğu, kadınların erkeklere kıyasla probiyotik bilgi düzeylerinin daha yüksek ve kadınların daha fazla probiyotik gıda tüketme eğiliminde olduğu saptanmıştır. [28][29][30] Üniversite öğrencilerinde probiyotik bilgi düzeylerinin ve tüketim durumunun araştırıldığı üç farklı çalışmada, kız öğrencilerin erkeklere kıyasla probiyotik ürünler hakkında daha fazla bilgiye sahip oldukları bulunmuştur.…”