Effects of Dangguibuxue Tang, a Chinese herbal medicine, on growth performance and immune responses in broiler chicks

Abstract

The eff ects of Dangguibuxue Tang (DBT) on growth performance and immunity response in immunosuppressed broiler chicks were investigated in this study. 240 one-d-old broiler chicks (DaHeng S01) were randomly divided into 4 groups, 2.0% DBT-treatment (A), 0.5% DBT-treatment (B), cyclophosphamide-control (C), and control group (D). From 4 d to 7 d of age, chicks in group A, B and C were given cyclophosphamide (CY) at a dosage of 100mg/kg body weight (BW) daily by intraperitoneal injection to induce immunosuppression. Chicks in group D were given an equal volume of physiological saline daily by intraperitoneal injection and considered normal chicks. Groups A and B were supplemented with 2.0% or 0.5% of DBT in the drinking water from 8 d to 42 d of age. Groups C and D did not receive any additional medication. The results revealed that chicks from group B had lower feed:gain rate (FGR), lower total mortality, higher immunity organ indexes, higher levels of Newcastle disease (ND) antibody and infectious bursal disease (IBD) antibody, higher interleukin-2 and interleukin-6 levels, and greater lymphocyte proliferative responses to concanavalin A (ConA) during the experiment than those from group C. However, no signifi cant diff erence in the immunity status in the two levels of DBT-treatment was observed. These results indicate that supplementation of 0.5% of DBT can improve both cellular immunity and humoral immunity in immunosuppressed broiler chicks.

Ameliorative Effect of Dangguibuxue Decoction against Cyclophosphamide-Induced Heart Injury in Mice

“…Traditional Chinese medicine has been acknowledged as a major source of medicine, which was used for centuries around the world [ 10 , 11 ]. Dangguibuxue decoction (DBD), a Chinese medicinal decoction that contains Angelicae sinensis radix (Danggui) and Astragalus radix (Huangqi) at a ratio of 1:5, has been widely used to treat blood deficiency disease in China for more than 800 years because of the hematopoietic properties of this prescription [ 12 ]. In Chinese, the herb Angelica sinensis is pronounced as Dang Gui; Bu Xue refers to hematopoietic effects.…”

Danggui Buxue Tang Rescues Folliculogenesis and Ovarian Cell Apoptosis in Rats with Premature Ovarian Insufficiency

“…DBT has been reported to promote erythropoietin, platelets, and angiogenesis [ 23 ]. The effects of stimulating the immune response [ 24 ] and alleviating myocardial damage [ 25 ] have also been reported [ 24 ]. DBT is composed of Angelica and Astragalus , and both herbs showed possible improvement in ovarian function.…”

Repressed Exercise-Induced Hepcidin Levels after Danggui Buxue Tang Supplementation in Male Recreational Runners

“…Previous studies have revealed numerous beneficial effects of DBT, such as renoprotective [ 40 ], hepatoprotective [ 41 , 42 ], cardioprotective [ 43 ], pulmonary protective [ 44 , 45 ], anti-inflammatory [ 46 ], immunostimulant [ 47 , 48 ], antioxidant [ 49 , 50 ], and erythropoietic [ 51 , 52 ] properties. However, the majority of these studies were in vitro tests and used animal models.…”