Effects Of Daunorubicin On Pulmonary Artery Smooth Muscle Cells In Rat Model Of Hypoxia-Induced Pulmonary Hypertension

Apoptosis-based therapy to treat pulmonary arterial hypertension

“…After pulmonary hypertension and vascular thickening were developed, DNR was administered. We found that, within 3 days, DNR at a concentration as low as 5-mg/kg body weight significantly reduced pulmonary arterial wall thickness, a reduction associated with increased apoptosis 11,12 . Importantly, neither the reduction of vascular wall thickness nor the induction of apoptosis occurred in the pulmonary vessels of normal control rats, suggesting that remodeled pulmonary vasculature is sensitive to DNR-induced cell killing.…”