Effects of dechlorane plus on oxidative stress, inflammatory response, and cell apoptosis in<i>Cyprinus carpio</i>

Li, Baohua; Qi, Pengju; Qu, Ying; Wang, Beibei; Chen, Jianjun; Chang, Zhongjie

doi:10.1080/01480545.2019.1701001

Cited by 12 publications

(1 citation statement)

References 58 publications

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“…Frontiers in Environmental Science frontiersin.org biological health (Li et al, 2020), and it can also induce oxidative damage and apoptosis of fish (Li et al, 2019).…”

Section: Graphical Abstractmentioning

confidence: 99%

Phytotoxicity, uptake, and translocation of two halogenated flame retardants and cadmium in two rice varieties

Liu

Xie

et al. 2022

Front. Environ. Sci.

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Dechlorane Plus (DP) and Tetrabromobisphenol A (TBBPA) are the halogenated flame retardant with the highest production volume, cadmium (Cd) is regarded as one of the hazardous heavy metals due to its bio toxicity and bioaccumulation in the environment, and it will cause environmental pollution and affect human health, so a pot experiment was conducted to investigate the phytotoxicity on seed germination and seedling of two rice varieties. The results showed that with the increasing of DP, TBBPA and Cd concentrations in soil, the germination rate, germination index and vigor index of two rice varieties decreased, and the germination of Number 7 rice was affected more than Number 1 rice. Halogenated flame retardants and Cd in soil significantly promoted root activity and proline, and significantly inhibited protein and soluble sugar contents of two rice varieties. In addition, the responses of the two rice varieties seedlings to different pollutants were obviously different. The activity of superoxide dismutase (SOD) in two kinds of rice was improved, and a large amount of malonyldialdehyde (MDA) was induced. But the activity of catalase (CAT) in Number 7 rice was increased under the action of DP and TBBPA, while the activity of Number 1 rice was increased under the action of DP and inhibited under the pollution of TBBPA. Bioaccumulation factors of DP and Cd were 0.025–0.042 and 6.59–14.20, bio transport coefficients were 0.39–0.48 and 0.034–0.087. There was no significant difference in the bioaccumulation of DP in the two rice varieties, but TBBPA and Cd were more easily bio accumulated in the Number 1 rice. These findings would provide some essential information for interpreting the ecological risks of two halogenated flame-retardants and Cd in plants.

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“…Frontiers in Environmental Science frontiersin.org biological health (Li et al, 2020), and it can also induce oxidative damage and apoptosis of fish (Li et al, 2019).…”

Section: Graphical Abstractmentioning

confidence: 99%

Phytotoxicity, uptake, and translocation of two halogenated flame retardants and cadmium in two rice varieties

Liu

Xie

et al. 2022

Front. Environ. Sci.

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Toxic effects of dechlorane plus on the common carp (Cyprinus carpio) embryonic development

Chen

et al. 2020

Chemosphere

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Dechlorane Plus (DP) is a widely using chlorinated flame retardant, and has been detected extensively in the environment. Even though the DP content in the surface water is low, it can pose a continuous exposure risk to aquatic organisms due to its strong bioaccumulation. Since related researches on the toxicity mechanism of DP exposure on carp embryo development are limited, we carried out the evaluation of DP effect on carp. In this study, Carp embryos were exposed to DP of 0, 30, 60, and 120 µg/L at 3h post fertilization (hpf). The expression of genes associated with the neural and skeletal development such as sox2, sox19a, Mef2c, and BMP4 were evaluated using quantitative PCR (qPCR), and analysis of different developmental toxicity endpoints changes were observed with microscopy. Our results demonstrated that the expression of sox2, sox19a, Mef2c, and BMP4 were significantly changed and several developmental defects were observed in the exposed carps embryo, such as DNA damage, increased mortality rate, delayed hatching time, decreased hatching rate, decreased body length, increased morphological deformities. In addition, reactive oxygen species (ROS) and malondialdehyde (MDA) were significantly increased with DP exposure at 60µg/L and 120 µg/L. Altogether, our results suggest that DP may have an unique modes of action, which results in aberration occurrence in the early development stage of common carps, that may relates to some gene damage and oxidative stress. Besides, the parameters evaluated here can be used as tools to access the environmental risk for biota and humans exposed to DP.

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A review on structural mechanisms of protein-persistent organic pollutant (POP) interactions

et al. 2023

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Effects of dechlorane plus on oxidative stress, inflammatory response, and cell apoptosis inCyprinus carpio

Cited by 12 publications

References 58 publications

Phytotoxicity, uptake, and translocation of two halogenated flame retardants and cadmium in two rice varieties

Phytotoxicity, uptake, and translocation of two halogenated flame retardants and cadmium in two rice varieties

Toxic effects of dechlorane plus on the common carp (Cyprinus carpio) embryonic development

A review on structural mechanisms of protein-persistent organic pollutant (POP) interactions

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