Effects of dehydroabietic acid on nontarget lipidomics and proteomics of HepG2

Xiahou, Zhikai; Han, Jianda

doi:10.3389/fphar.2022.1015240

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…Furthermore, phosphatidylinositol 4-diphosphate (PIP) plays a role in intracellular signal transduction, while phosphatidylglycerol (PG) is involved in the regulation of liver function, liver regeneration, and liver metabolism. SQDG is a glycerol glycolipid known for its antioxidant, antiviral, anti-inflammatory, and anti-atherosclerotic properties . KGM supplementation increased the relative abundance of PIP (50:3), PIP (50:4), PG (16:0/22:6), PG (16:0/22:6), PG (16:0/20:4), LPG (16:0), SQDG (44:2), SQDG (41:2) and SQDG (37:2) in mice fed a high-fat diet.…”

Section: Discussionmentioning

confidence: 99%

“…SQDG is a glycerol glycolipid known for its antioxidant, antiviral, anti-inflammatory, and anti-atherosclerotic properties. 25 KGM supplementation increased the relative abundance of PIP (50:3), PIP (50:4), PG (16:0/22:6), PG (16:0/22:6), PG (16:0/20:4), LPG (16:0), SQDG (44:2), SQDG (41:2) and SQDG (37:2) in mice fed a high-fat diet. Although KGM decreased the contents of PG (43:6) and SQDG (41:4) in mice on a normal diet, it did not significantly affect their total contents (Figure 6).…”

Section: ■ Discussionmentioning

confidence: 99%

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Effects of Konjac Glucomannan on Weight Management and Liver Health: Insights from Liver Lipidomics in Obese and Nonobese Mice

Jin,

Xia,

Deng

et al. 2024

J. Agric. Food Chem.

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Konjac glucomannan (KGM) is a water-soluble dietary fiber and is used for weight management. However, there is a lack of research on KGM for weight management in nonobese groups and the effects of high-dose KGM supplementation on liver function. This study investigated the metabolic responses to KGM intervention in obese and nonobese mice and explored the underlying mechanisms based on lipidomics. The findings demonstrated that KGM supplementation decreased body weight and mitigated lipid metabolism disorders at the mRNA and protein levels in obese mice. In contrast, no significant impact on these parameters was observed in nonobese mice. Interestingly, KGM had a more significant impact on remodeling hepatic lipid composition in obese mice compared to nonobese mice, leading to reducing harmful lipids and increasing beneficial lipids. However, high-dose KGM increased the risk of hepatocyte bile acid toxicity in obese mice and did not promote liver antioxidant status in nonobese mice. In summary, this study identified distinct metabolic responses to KGM intervention between obese and nonobese mice, providing insights for weight management using KGM.

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Section: Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Effects of Konjac Glucomannan on Weight Management and Liver Health: Insights from Liver Lipidomics in Obese and Nonobese Mice

Jin,

Xia,

Deng

et al. 2024

J. Agric. Food Chem.

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“…Bioinformatics analysis is widely used to explore the complex mechanisms and effective targets of drug treatment. According to the analysis of relevant data, dehydroabietic acid [ 239 ], curcumin [ 240 ], and Astragalus membranaceus [ 241 ] could exert their potential effect in treating HCC by regulating ferroptosis-related genes or pathways. It is expected that more effective targets will be identified with the development of various omics techniques and analytical methods.…”

Section: Nac Treat Liver Disease By Targeting Ferroptosismentioning

confidence: 99%

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Wu,

Zhu,

Liu

et al. 2024

Antioxidants

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Ferroptosis is an emerging type of regulated cell death usually accompanied by the accumulation of ferrous ions (Fe2+) and lipid peroxides. As the metabolic hub of the body, the liver is crucial for iron storage and lipid metabolism. The liver seems to be closely related to ferroptosis through iron and lipid metabolism. Liver disease greatly threatens host health, and exploring effective interventions is essential. Mounting studies have demonstrated that ferroptosis is one of the possible pathogenic mechanisms involved in liver disease. Targeting ferroptosis may provide a promising opportunity for treating liver disease. However, drugs targeting ferroptosis are extremely limited. Therefore, it is an urgent need to develop new and safe ferroptosis regulators. Natural active compounds (NAC), especially those derived from traditional Chinese medicine, have recently shown great therapeutic potential in liver disease via modulating ferroptosis-related genes or pathways. Here, we outline the molecular mechanism of ferroptosis and systematically summarize the regulatory function of NAC on ferroptosis in liver disease. Finally, we discuss the application prospects and potential problems concerning NAC as ferroptosis regulators for managing liver disease.

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Separation and Identification of Terpenoids in Three Pineapple Fibers Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

Liu,

Chen,

Liu

et al. 2024

Journal of Natural Fibers

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Effects of dehydroabietic acid on nontarget lipidomics and proteomics of HepG2

Cited by 5 publications

References 33 publications

Effects of Konjac Glucomannan on Weight Management and Liver Health: Insights from Liver Lipidomics in Obese and Nonobese Mice

Effects of Konjac Glucomannan on Weight Management and Liver Health: Insights from Liver Lipidomics in Obese and Nonobese Mice

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Separation and Identification of Terpenoids in Three Pineapple Fibers Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

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