Effects of demineralized bone matrix and a ‘Ricinus communis’ polymer on bone regeneration: a histological study in rabbit calvaria

Filho, José Rodrigues Laureano; Andrade, Emanuel S. S.; Barbosa, José Ricardo de Albergaría; Camargo, Igor Batista; Garcia, Robson Rodrigues

doi:10.2334/josnusd.51.451

Cited by 20 publications

(10 citation statements)

References 17 publications

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“…Furthermore, Pereira Junior et al, [38] also report a comparative study between polyurethanes containing castor oil (soft segment) and cancellous bone autograft in the treatment of segmental bone defects induced in rabbits [38]. As well by Laureano Filho et al, [39] analyzed the effect of Ricinus communis polymer on bone regeneration in rabbit calvaria [39]. …”

Section: Discussionmentioning

confidence: 99%

Chenopodium ambrosioides as a bone graft substitute in rabbits radius fracture

Neto

Ribeiro

Morais

et al. 2017

BMC Complement Altern Med

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BackgroundBone defects caused by trauma, infection or tumor resection are common in orthopedic clinic and depending on the extent of the fracture; the vast majority require treatment with bone substitutes. Among the bone grafts employees, the autograft is defined as the gold standard, but with some limitations, principally related to morbidity at the site of its removal, with the need to search for other biomaterials as adjuvant in bone regeneration. Therefore, the objective of the present study was to evaluate the use of Chenopodium ambrosioides as a bone graft substitute for the osseointegration of fractures in rabbits, compared to other bone grafts already employed in the surgical routine as Ricinus communis (castor oil) polyurethane and autogenous bone marrow.MethodsForty-eight rabbits were divided into four groups. After anesthesia, a radius fracture was created and the animals were treated with the following grafts: C. ambrosioides graft, autogenous bone marrow, castor oil and saline (control). After 30, 60 and 90 days, the animals were submitted to radiographical and histological analyses and bone alkaline phosphatase, osteocalcin, biomechanical tension, and collagen were measured. We also realized a phytochemical screening and in vitro antioxidant activity including 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical.ResultsThe data showed that the growth of the bone callus was more expressive and biomechanical assessment showed better tensile strength in C. ambrosioides graft. The experimental results also revealed that there was significantly greater activity of the bone alkaline phosphatase and osteocalcin during early fracture healing, similarly to the group receiving autogenous bone marrow. Histologically, immature bone was observed in C. ambrosioides graft at 30 days, whereas the formation of cartilaginous tissue predominated in the other groups. A higher amount of type I collagen was observed in C. ambrosioides graft throughout treatment. It was detected strong presence of flavonoids and appreciable antioxidant activity.ConclusionsThe results indicate that C. ambrosioides graft and autogenous bone marrow have similar ability to enhance bone regeneration, higher than the castor oil graft, suggesting that the medicinal plant can provide therapeutic benefits for bone tissue.

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Section: Discussionmentioning

confidence: 99%

Chenopodium ambrosioides as a bone graft substitute in rabbits radius fracture

Neto

Ribeiro

Morais

et al. 2017

BMC Complement Altern Med

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“…The analyses of crude drug new formulations with an accessible cost and that do not lead damage to the denture materials are required. The Ricinus communis solution appears to be viable due its biocompatibility, powerful detergent action, anti‐inflammatory activity, bactericidal and fungicidal potential, and effectiveness on remission of denture stomatitis …”

Section: Introductionmentioning

confidence: 99%

Evaluation of biofilm removal and adverse effects on acrylic resin by diluted concentrations of sodium hypochlorite and Ricinus communis solutions

et al. 2018

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“…This biopolymer has high capacity for interaction with human body cells in addition to not causing rejection. The success of the biopolymer can be explained by its compatibility with the human body [2,[4][5][6] .…”

Section: Introductionmentioning

confidence: 99%