Effects of deoxycorticosterone on plasma renin acitivity in conscious dogs

Robb, CA; Davis, JO; Johnston, C. I.; Pm, Hartroft

doi:10.1152/ajplegacy.1969.216.4.884

Cited by 15 publications

(6 citation statements)

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“…However, it is unlikely that an increase in plasma aldosterone concentration directly affects renin secretion. In previous studies of adult animals (Geelhoed and Vander, 1967), the investigators have been unable to identify a direct action of aldosterone on renin secretion unless the rise in circulating mineralocorticoids was associated with an increase in total body sodium (Robb et al, 1969), which is unlikely in the present study. More likely, the decline in fetal PRA observed in the present study may be secondary either to a direct action of All on the juxtaglomerular cells, as previously suggested in adult animals (Shade et al, 1973;McDonald et al, 1975), or to an increase in fetal renal perfusion pressure, or both.…”

Section: Influence Of Increase In Plasma All Concentration On Fetal Pcontrasting

confidence: 54%

Comparison of the adrenal and renal responses to angiotensin II fetal lambs and adult sheep.

Robillard

Gómez²,

VanOrden³

et al. 1982

Circulation Research

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SUMMARY The adrenal and renal responses to similar increases in plasma angiotensin II (All) were studied in chronically catheterized fetal lambs (112-131 days gestation; term 145 days) and adult nonpregnant sheep. The rate of All infusion was adjusted to compare the effect of similar rises in plasma AH concentration between fetuses and adult ewes. Increases in plasma All were associated with a decrease in plasma renin activity (PRA) in both fetuses (5.55 ± 1.53 to 2.11 ± 0.59 ng/ml per hr, P < 0.05) and adult ewes (1.28 ± 0.34 to 0.62 ± 0.16 ng/ml per hr, P< 0.05), but the percent changes in PRA for similar increases in plasma All were not different when fetuses were compared to adult ewes. Contrary to the effect of All on PRA, the increase in plasma All did not produce parallel changes in plasma aldosterone concentration when fetuses were compared to adult ewes. The percent changes in plasma aldosterone concentration for similar increases in All concentration were significantly higher in adult ewes (+165 ± 37%) than in fetuses (+58 ± 15%) (P < 0.01). Finally, there were no significant changes in fetal urinary excretion of PGE and PGF2a when a significant rise (P < 0.05) was observed in adult ewes at the highest level of plasma All concentration. In summary, the present results tend to suggest that there are differences between fetuses and adult ewes in the response to All, the response being smaller in fetuses.

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Section: Influence Of Increase In Plasma All Concentration On Fetal Pcontrasting

confidence: 54%

Comparison of the adrenal and renal responses to angiotensin II fetal lambs and adult sheep.

Robillard

Gómez²,

VanOrden³

et al. 1982

Circulation Research

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“…However, it is not at all likely that the changes in plasma renin produced by changes in dietary potassium described herein could be secondary to induced changes in aldosterone secretion. This is because a number of studies have indicated that the suppression of renin secretion by mineralocorticoids such as deoxycorticosterone or aldosterone is entirely secondary to the sodium retention induced by these steroids (18)(19)(20). Furthermore, in the present study, the effects of potassium on plasma renin often occurred in the face of changes in sodium balance which would be expected to have the opposite effect on renin secretion.…”

Section: Discussionmentioning

confidence: 65%

Potassium balance and the control of renin secretion

Sealey¹,

Clark²,

Bull³

et al. 1970

J. Clin. Invest.

156

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“…However, aldosterone excretion was increased to the same extent whether (group I) or not (group II) plasma renin was suppressed. Furthermore, there is a large body of evidence to indicate that aldosterone or other mineralocorticoids do not, by themselves, suppress plasma renin because the suppression produced by these hormones was found to be entirely consequent to induced sodium retention (21)(22)(23).…”

Section: Potassium Administration and Plasma Renin In Manmentioning

confidence: 99%

The influence of potassium administration and of potassium deprivation on plasma renin in normal and hypertensive subjects

Brunner¹,

Baer²,

Sealey³

et al. 1970

J. Clin. Invest.

223

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A B S T R A C T The effect of potassium administration and of dietary potassium deprivation on plasma renin activity and aldosterone excretion has been studied in 10 normal subjects and in 12 hypertensive patients maintained on a constant dietary regimen.Potassium administration reduced plasma renin activity in 18 of 28 studies of both normal and hypertensive subjects. Suppression of renin often occurred despite sodium diuresis induced by potassium administration. The renin suppression was related to induced changes in plasma potassium concentration and urinary potassium excretion.The failure of suppression of plasma renin in 10 studies could be accounted for by the smaller amounts of potassium administered to these subjects, together with a possibly overriding influence of an induced sodium diuresis.In six studies potassium deprivation invariably increased plasma renin activity even though a tendency for sodium retention often accompanied this procedure.The data indicate that both the suppression of plasma renin activity induced by potassium administration and the stimulation of renin activity which follows potassium depletion occur independently of associated changes in either aldosterone secretion or in sodium balance. However, the results do suggest that in various situations, the influence of potassium on plasma renin activity may be either amplified or preempted by changes in sodium balance.These interactions between potassium and plasma renin could be mediated by an ill-defined extrarenal pathway. But the findings are more consistent with an

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Effects of deoxycorticosterone on plasma renin acitivity in conscious dogs

Cited by 15 publications

References 0 publications

Comparison of the adrenal and renal responses to angiotensin II fetal lambs and adult sheep.

Comparison of the adrenal and renal responses to angiotensin II fetal lambs and adult sheep.

Potassium balance and the control of renin secretion

The influence of potassium administration and of potassium deprivation on plasma renin in normal and hypertensive subjects

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