Effects of Desflurane on Spinal Somatosensory-Evoked Potentials and Conductive Spinal Cord Evoked Potential

Abstract

The concentration of desflurane alters the amplitude of somatosensory-evoked potential and spinal cord evoked potential, and, to a lesser degree, delays the latency; spinal cord evoked potential is more liable to be suppressed than somatosensory-evoked potential. The dose-dependent suppression effect on amplitude should be considered when interpreting changes during surgery. Furthermore, the potential benefit of somatosensory-evoked potential elicited by direct major nerve stimulation should be considered because of its large amplitude and higher resistance, even with a greater concentration of volatile anesthetics.

Subthalamic deep brain stimulation after anesthetic inhalation in Parkinson disease: a preliminary study

“…A dose-dependent suppressive effect on amplitude in spinal somatosen- sory-evoked potentials in rats that have been anesthetized with desflurane has been reported. 9 Anesthesia with desflurane depresses the discharge rate of the globus pallidus externa and globus pallidus interna neurons, particularly in patients with PD. 20 Therefore, keeping the MAC < 1 with a low desflurane concentration will attenuate the depressive effect of desflurane on the MER.…”

Resección de lesiones cerebrales con asistencia de mapeo cortical intraoperatorio

“…Con desfl uorano o sevofl uorano se puede lograr una monitorización satisfactoria con CAM mayores (1,5-1,75). En estos pacientes se administró isofl uorano o sevofl uorano a concentraciones menores de un CAM sin N 2 O sin mayores repercusiones en la monitorización de los PEES [71][72][73] . Finalmente, si bien la utilización de rela-jantes musculares no afectan la interpretación de los PESS 72,74 , preferimos usar relajantes musculares de corta duración para no interferir con la estimulación cortical directa ni registro de potenciales evocados motores.…”