Effects of desmopressin on blood loss in hip arthroplasty

Flordal, Per Anders; Ljungström, Karl-Gösta; Ekman, Brenda; Neander, Gustaf

doi:10.3109/17453679209154749

Cited by 38 publications

(40 citation statements)

References 15 publications

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“…However, these favourable results could not be confirmed in subsequent studies [62][63][64]. Contrasting results were also reported by other small trials in total hip or knee arthroplasty [65][66][67]. It must be considered, however, that most of these trials had insufficient statistical power to detect true differences in postsurgical blood loss.…”

Section: Desmopressin In Other Types Of Surgerymentioning

confidence: 80%

The use of desmopressin in open‐heart surgery

Cattaneo

2007

Haemophilia

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Desmopressin (l-deamino-8-D-arginine vasopressin, DDAVP) is a synthetic analogue of the antidiuretic hormone vasopressin. Like the natural antidiuretic hormone, desmopressin increases the plasma levels of factor VIII and von Willebrand factor (vWF), with the advantage, compared to vasopressin, that it produces little or no vasoconstriction, no increase in blood pressure, and no contraction of the uterus or gastrointestinal tract, so that it is well tolerated when administered to humans. In 1977, desmopressin was used for the first time in patients with mild hemophilia A and von Willebrand disease (vWD) for the prevention and treatment of bleeding, first during dental extractions and then during major surgical procedures. The clinical indications for desmopressin rapidly expanded beyond hemophilia and vWD. The compound was shown to be efficacious even in bleeding disorders not involving a deficiency or dysfunction of factor VIII or vWF, including congenital and acquired defects of platelet function and such frequent abnormalities of hemostasis as those associated with chronic kidney and liver diseases. Desmopressin has also been used prophylactically in patients undergoing surgical operations characterized by large blood loss and transfusion requirements.

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Section: Desmopressin In Other Types Of Surgerymentioning

confidence: 80%

The use of desmopressin in open‐heart surgery

Cattaneo

2007

Haemophilia

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“…Several clinical trials failed to show any difference in blood loss and transfusion requirements when desmopressin was used in elective THR or TKR in haematologically normal patients. [61][62][63] A Cochrane systematic review concluded that there was no convincing evidence that desmopressin reduced allogenic blood transfusion in patients who did not have congenital bleeding disorders. 64 High-dose aprotinin, a fibrinolytic inhibitor, was found to reduce blood loss in primary and revision THR, TKR and spinal fusion.…”

Section: Methods Of Reducing Blood Transfusionmentioning

confidence: 99%

Strategies for blood management in orthopaedic and trauma surgery

Lemaire¹

2008

The Journal of Bone and Joint Surgery. British volume

130

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“…In fact, while Kobrinsky et al [59] reported a beneficial effect in terms of blood loss and transfusion requirements, Guay et al found no benefit [60]. Three trials showed no significant differences in blood loss or transfusion requirements when desmopressin was used in elective total hip/knee arthroplasty [61][62][63]. Moreover, a comparative prospective study found that tranexamic acid had better postoperative blood-sparing effects than desmopressin after total knee replacement [64].…”

Section: Desmopressin In Patients Without Preexisting Bleeding Disordersmentioning

confidence: 99%

The use of desmopressin as a hemostatic agent: A concise review

Franchini

2007

American J Hematol

126

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Desmopressin, a synthetic derivative of the antidiuretic hormone vasopressin, is the treatment of choice for most patients with von Willebrand disease and mild hemophilia A. Moreover, the compound has been shown to be useful in a variety of inherited and acquired hemorrhagic conditions, including some congenital platelet function defects, chronic liver disease, uremia, and hemostatic defects induced by the therapeutic use of antithrombotic drugs such as aspirin and ticlopidine. Finally, desmopressin has been used as a blood saving agent in patients undergoing operations characterized by large blood loss and transfusion requirements, but studies suggest that this is not as effective as other methods. This review briefly summarizes the current clinical indications on the use of desmopressin as a hemostatic agent. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.

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Effects of desmopressin on blood loss in hip arthroplasty

Cited by 38 publications

References 15 publications

The use of desmopressin in open‐heart surgery

The use of desmopressin in open‐heart surgery

Strategies for blood management in orthopaedic and trauma surgery

The use of desmopressin as a hemostatic agent: A concise review

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