Effects of desogestrel and levonorgestrel in low-dose oestrogen oral contraceptives on serum lipoproteins

Bergink, E.W.; Borglin, N. E.; Klottrup, P; Liukko, P.

doi:10.1016/0010-7824(82)90037-3

Cited by 36 publications

(11 citation statements)

References 27 publications

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“…A further reduction in EE below 30 pg per pill with norethisterone resulted in high pregnancy rates and intolerable vaginal bleeding patterns (7). Furthermore, with norethisterone or levonorgestrel as the progestational agent in a pill with less than 30 pg EE, there would be a risk of adverse effects on lipid and lipoprotein patterns, due to the androgenic properties of these progestogenes (8,9).…”

mentioning

confidence: 99%

Oral contraceptive tablets containing 20 and 30 μg of ethinyl estradiol with 150 μg desogestrel: Their influence on lipids, lipoproteins, sex hormone binding globulin and testosterone

Åkerlund

Almström

Högstedt

et al. 1994

Acta Obstet Gynecol Scand

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The effect of two oral contraceptive (OC) pills, both containing 150 micrograms of desogestrel, but with 20 (Mercilon) or 30 micrograms (Marvelon/Desolett) of ethinyl estradiol on plasma levels of lipids, lipoproteins and sex hormone binding globulin (SHBG), total and free testosterone were compared in a double-blind, randomized, two-center study in a total of 60 women over one year. A significant rise with Marvelon but not with Mercilon was seen in total cholesterol, HDL cholesterol, HDL-3 and apolipoprotein B, whereas LDL cholesterol decreased with Mercilon only. These effects resulted in significant differences between the two groups in the magnitude of responses in all these parameters except HDL-3. HDL-2, apolipoprotein A-1 and total phospholipids were elevated with both pills after treatment and with no difference in the degree of response between groups. The HDL/LDL cholesterol ratio tended to increase in both groups and that of apolipoproteins A-1/B in the women on Mercilon. Total triglycerides increased in both groups, but more in the women on Marvelon. Total testosterone decreased, particularly in the Marvelon group, whereas the two pills caused a similar increase in SHBG and decrease in free testosterone. It is concluded that the direction of changes in plasma lipids and lipoproteins with both these pills may as a whole be interpreted as beneficial, and that the differences in effect on LDL cholesterol and apolipoprotein B may suggest a slightly advantageous effect of Mercilon in this aspect. However, the clinical significance of these changes is uncertain. The results indicate a lack of androgenicity of both pills.

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mentioning

confidence: 99%

Oral contraceptive tablets containing 20 and 30 μg of ethinyl estradiol with 150 μg desogestrel: Their influence on lipids, lipoproteins, sex hormone binding globulin and testosterone

Åkerlund

Almström

Högstedt

et al. 1994

Acta Obstet Gynecol Scand

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“…However, this combination was reported to have poor cycle control (Bounds et al 1979). Furthermore, with norethisterone or levonorgestrel as the progestational agent in a pill with less than 30 μg EE, there would be a risk of adverse effects on lipoprotein patterns due to the androgenic properties of these progestogens (Bergink et al 1982; Fotherby 1985).…”

mentioning

confidence: 99%

Comparative profiles of reliability, cycle control and side effects of two oral contraceptive formulations containing 150 μg desogestrel and either 30 μg or 20 μg ethinyl oestradiol

Åkerlund

Rode

Westergaard

1993

BJOG

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Objective To compare two oral contraceptive pills, both containing 150 μg desogestrel, but with either 20 μg (Mercilon®) or 30 μg (Marvelon®/Desolett®) ethinyl oestradiol (EE), regarding reliability, cycle control and side effect profile. Design A double blind, randomised, multicentre study over one year with follow up after three, six and 12 months. The women noted tablet intake and all bleedings on specifically designed diary cards. Setting University clinics, central hospitals and private gynaecological practices in Norway, Sweden and Denmark. Subjects One thousand women aged 18 to 40 years requesting oral contraceptive pills. Main outcome measures Reliability, cycle control, side effects, blood pressure, body weight and haemoglobin. Results In a total of 4543 cycles with the 20 μg EE dose pill and 4688 cycles with the 30 μg EE dose pill, the number of pregnancies ascribed to method failure were 0 and 2, respectively. Irregular bleeding (breakthrough bleeding or spotting) was signficantly more frequent with the 150/20 combination in about two‐thirds of the cycles randomly distributed over the one year of the study. Mean blood pressure decreased slightly, particularly in the group on the 150/20 combination (about 1 mmHg), whereas mean body weight increased approximately 0.5 kg in the group with the 150/30 combination after 12 months. Haemoglobin did not change. Side effects other than bleeding problems were rare, but dizziness and mood changes were more frequent in the group on the 150/20 combination. Due to side effects, more women on the 150/20 combination discontinued the study during the one to three and four to six month periods, and women on this pill were also less positive about continuing the study drug at the end of the trial. Conclusions Both pills have high contraceptive reliability and are well tolerated, but with the 150/20 combination the cycle control is less effective. However, in view of the potentially increased safety profile of the 150/20 combination, many women can be expected to accept some additional discomfort due to irregular bleeding.

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“…The DOG formulation was shown to have a pronounced and significantly greater SHBGraising effect than the LNG formulation [25,27]. A new similar formulation containing the same dose and type of estrogen (30/zg EE) combined with the same dose of a different progestogen, i.e.…”

Section: Evaluating Pill Formulationsmentioning

confidence: 99%

“…The greater inherent estrogenicity of the DOG combination led to the following results when compared to the same-dosed 150/30 LNG combination; a greater rise of plasma HDL; a greater rise of plasma triglycerides and insulin; and a greater increase of coagulation factors and a decrease of fibrinolytic factors [27][28][29][30][31].…”

Section: Evaluating Pill Formulationsmentioning

confidence: 99%

The pill, the heart and HDL: Facts and fictions

Hoppe¹

1986

Adv Contracept

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Effects of desogestrel and levonorgestrel in low-dose oestrogen oral contraceptives on serum lipoproteins

Cited by 36 publications

References 27 publications

Oral contraceptive tablets containing 20 and 30 μg of ethinyl estradiol with 150 μg desogestrel: Their influence on lipids, lipoproteins, sex hormone binding globulin and testosterone

Oral contraceptive tablets containing 20 and 30 μg of ethinyl estradiol with 150 μg desogestrel: Their influence on lipids, lipoproteins, sex hormone binding globulin and testosterone

Comparative profiles of reliability, cycle control and side effects of two oral contraceptive formulations containing 150 μg desogestrel and either 30 μg or 20 μg ethinyl oestradiol

The pill, the heart and HDL: Facts and fictions

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