Effects of Developmental Deltamethrin Exposure on White Adipose Tissue Gene Expression

Armstrong, Laura E.; Driscoll, Maureen V.; More, Vijay R.; Donepudi, Ajay C.; Xu, Jialin; Baker, A. K.; Aleksunes, Lauren M.; Richardson, Jason R.; Slitt, Angela L.

doi:10.1002/jbt.21480

Cited by 4 publications

(6 citation statements)

References 21 publications

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“…Based on the documented exposure of pregnant women to pyrethroids (20–22) and to mimic likely exposures in the human population, female mice were orally administered either 0.3, 1, or 3 mg/kg deltamethrin (ChemService, West Chester, PA, USA) dissolved in corn oil vehicle and mixed with peanut butter every 3 d during gestation and lactation (23). These doses are lower than the developmental no observable adverse effect level (12 mg/kg) (24) and span the no observable effect level (1 mg/kg), which is used by the Environmental Protection Agency to set allowable limits of pesticide exposure of humans.…”

Section: Methodsmentioning

confidence: 99%

Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder

et al. 2015

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Attention-deficit hyperactivity disorder (ADHD) is estimated to affect 8-12% of school-age children worldwide. ADHD is a complex disorder with significant genetic contributions. However, no single gene has been linked to a significant percentage of cases, suggesting that environmental factors may contribute to ADHD. Here, we used behavioral, molecular, and neurochemical techniques to characterize the effects of developmental exposure to the pyrethroid pesticide deltamethrin. We also used epidemiologic methods to determine whether there is an association between pyrethroid exposure and diagnosis of ADHD. Mice exposed to the pyrethroid pesticide deltamethrin during development exhibit several features reminiscent of ADHD, including elevated dopamine transporter (DAT) levels, hyperactivity, working memory and attention deficits, and impulsive-like behavior. Increased DAT and D1 dopamine receptor levels appear to be responsible for the behavioral deficits. Epidemiologic data reveal that children aged 6-15 with detectable levels of pyrethroid metabolites in their urine were more than twice as likely to be diagnosed with ADHD. Our epidemiologic finding, combined with the recapitulation of ADHD behavior in pesticide-treated mice, provides a mechanistic basis to suggest that developmental pyrethroid exposure is a risk factor for ADHD.

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Section: Methodsmentioning

confidence: 99%

Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder

et al. 2015

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“…63 However, two studies of prenatal exposure to deltamethrin, which is also used in indoor residual spraying and metabolizes into cis-DBCA and 3-PBA, found no effect on mouse offspring weight at birth 64 nor in adulthood. 65 Our results also suggest that prenatal exposure to pyrethroid insecticides may be associated with earlier age at peak weight velocity, though estimates were imprecise. The timing of peak weight velocity identified by the SITAR model is consistent with minipuberty, a period of HPG axis activation occurring in the first few months of life characterized by surges in gonadotropins and sex hormones that drives a growth spurt.…”

Section: Main Findings and Interpretationmentioning

confidence: 59%

Prenatal Exposure to Insecticides and Weight Trajectories Among South African Children in the VHEMBE Birth Cohort

et al. 2022

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Background: Dichlorodiphenyltrichloroethane (DDT) or pyrethroid insecticides are sprayed inside dwellings for malaria vector control, resulting in high exposure to millions of people, including pregnant women. These chemicals disrupt endocrine function and may affect child growth. To our knowledge, few studies have investigated the potential impact of prenatal exposure to DDT or pyrethroids on growth trajectories. Methods: We investigated associations between gestational insecticide exposure and child growth trajectories in the Venda Health Examination of Mothers, Babies and their Environment, a birth cohort of 751 children born between 2012 and 2013 in South Africa. Based on child weight measured at follow-up and abstracted from medical records, we modeled weight trajectories from birth to 5 years using SuperImposition, Translation and Rotation, which estimated two child-specific parameters: size (average weight) and tempo (age at peak weight velocity). We estimated associations between peripartum maternal concentrations of serum DDT, dichlorodiphenyldichloroethylene, or urinary pyrethroid metabolites and SuperImposition, Translation and Rotation parameters using marginal structural models. Results: We observed that a 10-fold increase in maternal concentrations of the pyrethroid metabolite trans-3-(2,2,-dicholorvinyl)-2,2-dimethyl-cyclopropane carboxylic acid was associated with a 21g (95% confidence interval = −40, −1.6) smaller size among boys but found no association among girls (P interaction = 0.07). Estimates suggested that pyrethroids may be associated with earlier tempo but were imprecise. We observed no association with serum DDT or dichlorodiphenyldichloroethylene. Conclusions: Inverse associations between pyrethroids and weight trajectory parameters among boys are consistent with hypothesized disruption of androgen pathways and with our previous research in this population, and support the endocrine-disrupting potential of pyrethroids in humans.

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“…Adult offspring treated with dichlorodiphenyltrichloroethane (DDT) during pregnancy exhibited higher blood glucose during oral glucose challenge and reduced Glut4 expression in adipose tissue. Transcriptional down-regulation of genes encoding for this glucose transporter was also reported in white fat tissue of adult mice after perinatal exposure to the pyrethroid insecticide deltamethrin 64 …”

Section: Susceptibility Of Developing Pancreas During Perinatal Life mentioning

confidence: 77%

“…Transcriptional down-regulation of genes encoding for this glucose transporter was also reported in white fat tissue of adult mice after perinatal exposure to the pyrethroid insecticide deltamethrin. 64…”

Section: Pesticidesmentioning

confidence: 99%

Food contaminants and programming of type 2 diabetes: recent findings from animal studies

Firmin
¹
,

Bahi-Jaber
²
,

Abdennebi-Najar
³

2016

J Dev Orig Health Dis

6
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3
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It is now accepted that the way our health evolves with aging is intimately linked to the quality of our early life. The present review highlights the emerging data of Developmental Origins of Health and Disease field on developmental disruption by toxicants and their subsequent effect on type 2 diabetes. We report adverse neonatal effects of several food contaminants during pregnancy and lactation, among them bisphenol A, chlorpyrifos, perfluorinated chemicals on pancreas integrity and functionality in later life. The described alterations, in conjunction with disruption of β cell mass in early life, can lead to dysregulation of glucose metabolism, insulin synthesis, which facilitates the development of insulin resistance and progression of diabetes in the adult. Despite limited and often inconclusive epidemiologic and experimental data, more recent data clearly show that infants appear to be at increased risk of type 2 diabetes in later life. This may be a result of continued exposure to chemical food contaminants during the critical window of pancreas development. In societies already burdened with increased incidence of non-communicable chronic diseases, there is a clear need for information regarding the potential harmful effects of chemical food contaminants on adult health diseases.

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Effects of Developmental Deltamethrin Exposure on White Adipose Tissue Gene Expression

Cited by 4 publications

References 21 publications

Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder

Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder

Prenatal Exposure to Insecticides and Weight Trajectories Among South African Children in the VHEMBE Birth Cohort

Food contaminants and programming of type 2 diabetes: recent findings from animal studies

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