1999
DOI: 10.1007/s002130050920
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Effects of dexamethasone on neuroendocrine and psychological responses to L-tryptophan infusion

Abstract: These data contrast with a previous study using hydrocortisone in the same paradigm and demonstrate important functional differences between dexamethasone and hydrocortisone.

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Cited by 14 publications
(11 citation statements)
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“…In a further study, in 26 depressed patients, administration of dexamethasone also reduced availability of both TRP and TYR (Maes 1990b) (see Table 1). In contrast, two studies (Traskman-Bendz et al 1986;Porter et al 1999) showed no effect of dexamethasone on L-TRP levels in healthy controls. However, these studies were smaller and did not measure other LNAA levels.…”
Section: Tryptophan Availabilitymentioning
confidence: 78%
“…In a further study, in 26 depressed patients, administration of dexamethasone also reduced availability of both TRP and TYR (Maes 1990b) (see Table 1). In contrast, two studies (Traskman-Bendz et al 1986;Porter et al 1999) showed no effect of dexamethasone on L-TRP levels in healthy controls. However, these studies were smaller and did not measure other LNAA levels.…”
Section: Tryptophan Availabilitymentioning
confidence: 78%
“…Indeed, a functional MR could protect the brain from pro-apoptotic signals (Crochemore et al 2005) and could attempt to maintain resilience by stimulating serotonergic neurotransmission , 2001Cowen 2002;Porter et al 2004). In this regard, it is of note that cortisol and dexamethasone seem to have different effects of serotonergic function in humans (Porter et al 1998(Porter et al , 1999, thus supporting the notion of a specific role of the MR vs GR receptors in the pathophysiology of depression.…”
Section: Discussionmentioning
confidence: 91%
“…However, other studies have shown a positive correlation between post-dexamethasone cortisol levels and baseline PRL (Joyce et al 1985) suggesting that high cortisol levels may reduce dopaminergic function. Studies have also suggested a direct effect of dexamethasone on PRL release from the pituitary (Naess et al 1980); however, dexamethasone has very different properties from the endogenous steroid cortisol (Porter et al 1999). In the current study, we also included a direct test of pituitary PRL release.…”
Section: Discussionmentioning
confidence: 97%
“…Therefore, this test is a measure of general 5-HT function and of the integrity of receptors other than the 5-HT 1A receptor. Recent studies in healthy volunteers have shown that the PRL response to intravenous l-TRP is blunted by pre-treatment with dexamethasone (Porter et al 1999) and the GH response is blunted by acute administration of hydrocortisone (Porter et al 1998).…”
Section: Introductionmentioning
confidence: 98%