Effects of dexmedetomidine on immune function, renal function and inflammatory factors of patients undergoing percutaneous nephrolithotomy under general anesthesia

Bai, Yu-yan; He, Hefan; Zhang, Peisen; Liu, Weifeng; Huang, Lirong

doi:10.3892/etm.2021.9837

Cited by 7 publications

(8 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, adjunct analgesic (such as ropivacaine) combined with epidural block is also reported to repress in ammation and improve immune functions in GC surgery [33,34]. Interestingly, the effects of dexmedetomidine on in ammatory cytokines and T lymphocytes are con rmed in patients with kidney calculi [35] or GC surgery [36] without any block. In this study, to our knowledge, we for the rst time investigated the in uences of dexmedetomidine in combination with ropivacaine in TPVB on in ammation and immune functions for GC patients undergoing open gastrectomy.…”

Section: Discussionmentioning

confidence: 99%

Postoperative analgesic effect of dexmedetomidine combined with TPVB applied to open gastrectomy for gastric cancer

Wan

Hou

Qiu

2022

Immunopharmacology and Immunotoxicology

View full text Add to dashboard Cite

Purpose: This study is aimed to investigate the analgesic effect of combined dexmedetomidine and thoracic paravertebral nerve block (TPVB) on gastric cancer (GC) patients undergoing open gastrectomy.Methods: From May 2019 to Nov 2020, a total of 80 GC patients preparing for open gastrectomy were enrolled in our hospital and were divided into the ropivacaine (RO) group and the ropivacaine + dexmedetomidine (RD) group ad libitum. All of the patients underwent TPVB. The characteristics, usage of patient-controlled analgesia (PCA), adverse events, visual analogue scale (VAS) scores, in ammatory cytokines, and T cell subgroups between the two groups were compared. Patients in the RD group showed the decreased occurrence rate of postoperative adverse events and VAS scores and improved anti-in ammation and immune function.Results: These ndings implied that the application of dexmedetomidine in combination with ropivacaine in TPVB has a good postoperative analgesic effect, as well as anti-in ammatory and immune-enhancing effects.Conclusion: Thus, dexmedetomidine as an adjunct analgesic may be potentially applied in clinical practice for GC patients undergoing open gastrectomy.

show abstract

Section: Discussionmentioning

confidence: 99%

Postoperative analgesic effect of dexmedetomidine combined with TPVB applied to open gastrectomy for gastric cancer

Wan

Hou

Qiu

2022

Immunopharmacology and Immunotoxicology

View full text Add to dashboard Cite

show abstract

“…Different methods of surgery, such as shockwave lithotripsy, flexible ureteroscopy, conventional/mini-percutaneous nephrolithotomy (PCNL), laparoscopic/robotic surgery and open procedures, are the primary treatments for kidney stones 11. PCNL has become the primary method of treating kidney stones thanks to the advancement of medical technology 12. Although PCNL has a high success rate (85~93%), the postoperative complication rate reaches 18% 13 14.…”

Section: Introductionmentioning

confidence: 99%

Safety and efficacy of enhanced recovery after surgery among patients undergoing percutaneous nephrolithotomy: protocol for a systematic review and meta-analysis

Liu,

Yue,

Xiao

et al. 2023

BMJ Open

View full text Add to dashboard Cite

IntroductionEnhanced recovery after surgery is widely used in the perioperative period in the field of urology; however, it lacks comprehensive and systematic evidence supporting its efficacy and safety after percutaneous nephrolithotomy. This meta-analysis aimed to assess the safety and efficacy of enhanced recovery after percutaneous nephrolithotomy.Methods and analysisRelevant databases, including PubMed, Web of Science, Embase, The Cochrane Library, China Knowledge Resource Integrated Database, Wanfang Database, Chinese Biomedical Document Service System, and Chinese Science and Technology Journal Database, will be searched from their inception to 19 September 2022. Two researchers will independently screen the literature, extract data and evaluate the included studies. The Grading of Recommendations, Assessment, Development, and Evaluation will be used to assess the degree of certainty of the evidence. Based on the Cochrane Handbook V.5.1.0, the risk of bias assessment of the included randomised controlled trials will be assessed. Based on their randomisation method, allocation generation, concealment, blinding and follow-up, we will assess randomised controlled trials. Random-effects and fixed-effects models and subgroup analyses will be used for meta-analysis. RevMan V.5.4.1 will be used for data collection and meta-analysis.Ethics and disseminationDue to the nature of this systematic review, ethics approval is not required for this study. We will publish the results of this review in a peer-reviewed journal.PROSPERO registration numberCRD42023411520.

show abstract

“…In particular, some anesthesia procedure or drugs might influence renal function. [6][7][8][9][10][11][12] Thus, an urgent clinical problem is to protect perioperative renal function and to promote early postoperative recovery. Quadratus lumborum block (QLB) is an abdominal truncal block that provides analgesia for abdominal surgery including laparoscopic gastrectomy, cesarean section, laparoscopic colorectal surgery, laparoscopic hepatectomy, and LRS.…”

Section: Introductionmentioning

confidence: 99%

Effects of Subcostal Anterior Quadratus Lumborum Block with and without Dexmedetomidine on Postoperative Rehabilitation in Patients Undergoing Laparoscopic Renal Surgery: A Prospective Double-Blinded Randomized Controlled Study

Li,

Wang,

Sun

et al. 2023

DDDT

View full text Add to dashboard Cite

The combination of different anesthesia techniques or adjuvant drugs can relieve the stress response to surgery, reduce adverse reactions and improve the clinical outcome. We investigated the effects of subcostal anterior quadratus lumborum block (SQLB) with and without dexmedetomidine (DEX) on postoperative rehabilitation for laparoscopic renal surgery (LRS). Methods: We included 90 patients in this single-center study. All were scheduled for elective laparoscopic radical or partial nephrectomy under general anesthesia (GA). We randomly and evenly assigned them to three groups: Group GA (GA alone), Group QG (SQLB with 30 mL of 0.25% ropivacaine and GA), and Group DQG (SQLB with 30 mL of 0.25% ropivacaine plus 1 μg/kg DEX and GA). The primary outcomes were serum creatinine (Cr) and blood urea nitrogen (BUN) levels; the secondary outcomes included the average numeric rating scale (NRS) scores at rest and during activity within 48 h postoperatively; perioperative opioid consumption; the time to first ambulation, exhaust, and fluid intake, and postoperative adverse reactions. Results:The serum Cr and BUN levels in Group DQG decreased significantly compared with Group GA (P < 0.05). The average NRS scores in Group DQG were significantly lower than other two groups (P < 0.05). Furthermore, the indexes reduced significantly in Group QG compared with Group GA (P < 0.05). Groups DQG and QG had lower consumption of opioid compared with Group GA (P < 0.05). The recovery indicators in Groups DQG and QG were higher quality than Group GA (P < 0.05). The incidences of adverse reactions in Group DQG was significantly lower than the other groups (P < 0.05). Conclusion: SQLB with and without DEX could attenuate postoperative pain, reduce opioids requirement and side effects, as well as facilitate postoperative early rehabilitation. More interesting, SQLB with DEX could confer kidney protection.

show abstract

Effects of dexmedetomidine on immune function, renal function and inflammatory factors of patients undergoing percutaneous nephrolithotomy under general anesthesia

Cited by 7 publications

References 34 publications

Postoperative analgesic effect of dexmedetomidine combined with TPVB applied to open gastrectomy for gastric cancer

Postoperative analgesic effect of dexmedetomidine combined with TPVB applied to open gastrectomy for gastric cancer

Safety and efficacy of enhanced recovery after surgery among patients undergoing percutaneous nephrolithotomy: protocol for a systematic review and meta-analysis

Effects of Subcostal Anterior Quadratus Lumborum Block with and without Dexmedetomidine on Postoperative Rehabilitation in Patients Undergoing Laparoscopic Renal Surgery: A Prospective Double-Blinded Randomized Controlled Study

Contact Info

Product

Resources

About