Effects of dexmedetomidine versus morphine on surgical stress response and analgesia in postoperative open cardiac surgery

Evaluation of dexmedetomidine as a sole agent in sedation of cancer patients undergoing radiological interventional procedures

“…In agreement with the present study, Aantaa et al and Al-Medani et al [21,22] who concluded that, there was no statistically significant difference in the mean cortisol and glucose values immediately postoperatively, Al-Medani et al added in research that at 6 and 24 h postoperatively, the mean values of cortisol and glucose increased significantly in the group of patients receiving morphine relative to the group of patients receiving dexmedetiomidine. We might say that dexmedetomidine may have modified cortisol release but not completely inhibited steroidogenesis as part of an inevitable physiological response, putting into consideration the time of starting dexmedetomidine administration, we also did not measure the level of serum catecholamine and IL6 as a part of the whole process to fully judge the entire scene.…”

Comparison of the Effect of Propofol and Dexmedetomidine on Hemodynamic Parameters and Stress Response Hormones During Laparoscopic Cholecystectomy Surgery

“…Besides vasodilatory effects, alpha-2 agonists have sympathetic suppressive, sedative, and hypnotic effects (26). Alpha-2 agonists, such as clonidine, have a blood pressure lowering effect, and therefore reduce surgical bleeding (16,27); in addition, dexmedetomidine facilitates analgesia and anesthesia in humans and reduces the severity of postoperative pain and nausea (28)(29)(30). This drug is approved for use for up to 24 hours at a maximum dose of 0.7 micrograms per kilogram of body weight per hour (31).…”