Effects of dexpanthenol and N-acetylcysteine pretreatment in rats before renal ischemia/reperfusion injury

Şen, Hüseyin; Deniz, Süleyman; Yedekçi, Ahmet Ertürk; İnangil, Gökhan; Müftüoğlu, Tuba; Haholu, Aptullah; Özkan, Sezai

doi:10.3109/0886022x.2014.949768

Cited by 16 publications

(12 citation statements)

References 20 publications

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“…NAC is a free radical scavenger, which in acute renal injury has ameliorative effects on inflammatory responses, such as the inhibition of cytokine expression and the suppression of NF-κB [28]. In agreement with this study, the inhibition of proinflammatory cytokines by NAC was demonstrated in an animal model of acute kidney injury [27].…”

Section: Discussionsupporting

confidence: 86%

Additional effects of erythropoietin pretreatment, ischemic preconditioning, and N-acetylcysteine posttreatment in rat kidney reperfusion injury

et al. 2019

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Background/aim: Since the nature of ischemia/reperfusion (IR)-induced tissue damage is multifactorial and complex, in the current study, the effects of multiple treatment strategies via concomitant administration of erythropoietin (EPO) and N-acetylcysteine (NAC) with an ischemic preconditioning (IPC) regimen on renal IR injury were examined. Materials and methods:Thirty male Wistar rats were subjected to bilateral occlusion of the renal pedicles for 50 min followed by reperfusion. EPO (1000 IU/kg) was administered for 3 days, as well as IPC before the IR and NAC (150 mg/kg) administration for 4 days after IR. The animals were randomly allocated into 6 groups (n = 5): sham, IR, EPO+IR, IPC+IR, NAC+IR, and EPO+IPC+NAC+IR. Kidney tissues and blood samples were obtained for oxidative stress, proinflammatory cytokines, and renal functional evaluations.Results: IR caused significant inflammatory response, oxidative stress, and reduced renal function. Treatment with EPO, IPC, and NAC or a combination of two of them attenuated renal dysfunction and reduced the oxidative stress and inflammatory markers. Rats treated with the combination of EPO, IPC, and NAC showed a higher degree of protection compared to the other groups. Conclusion:These results showed that concomitant administration of EPO and IPC along with posttreatment NAC may have additive beneficial effects on kidney IR injury during IR-induced acute renal failure.

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Section: Discussionsupporting

confidence: 86%

Additional effects of erythropoietin pretreatment, ischemic preconditioning, and N-acetylcysteine posttreatment in rat kidney reperfusion injury

et al. 2019

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“…The study groups were defined as follows: The rats of the control group were not administered anything else than standard rat feed and water. The rats in the Dexp group were administered a single dose intraperitoneal Dexp at a dose of 500 mg/kg for 3 days (Bepanthene 500 mg vials, Bayer Corp, Istanbul, Turkey) ( 12 ). The dosage range at which Dexp exerts its cytoprotective effect has been shown by the previous studies.…”

Section: Methodsmentioning

confidence: 99%

Protective effect of dexpanthenol against cisplatin‑induced hepatotoxicity

et al. 2018

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The aim of the present study was to investigate the protective effect of dexpanthenol (Dexp) against cisplatin (Cis)-induced hepatotoxicity. Thirty-two Sprague Dawley rats were divided into four groups: Control group (n=8), Dexp group (n=8, 500 mg/kg/ip/daily single dose/3 days Dexp), Cis group (n=8, 7 mg/kg/ip/single dose Cis) and Cis+Dexp group (n=8, 500 mg/kg/ip/daily single dose/3 days Dexp +7 mg/kg/ip/single dose Cis). MDA, CAT, GSH, GSH-Px, TOS, TAS, OSI, Total Nitrit, IL-1β, IL-6 and TNF-α levels were analyzed in liver tissue samples. After paraffinization of liver tissue samples, histopathological (congestion, loss of glycogen, number of Kupffer cells) and immunohistochemical (caspase-3 expression) parameters were assessed on the paraffinized liver sections. GSH, TAS, TOS, OSI, Tot Nit, L-Arginine, ADMA and SDMA levels were measured in the serum samples. Statistically significant differences were found between the groups in terms of all liver tissue biochemical parameters, with the exception of IL-1β and TNF-α levels. GSH, CAT, GSH-Px, TAS and Tot Nit levels were significantly higher in the Cis+Dexp group compared to the Cis group, whereas MDA, TOS, OSI and IL-6 levels were higher in the Cis group. Similarly, serum GSH, TAS, Tot Nit levels were higher in the Cis+Dexp group whereas TOS, L-Arginine, ADMA and SDMA levels were higher in Cis group. There were statistically significant differences between Control and Cis groups in terms of congestion increase, increase of glycogen loss, increase of Kupffer cell number and increase of caspase-3 expression (P<0.001). There was a statistically significant difference between the Cis and the Cis+Dexp groups in terms of histopathologic parameters, with the exception of congestion (P<0.001). To conclude, histopathological, immunohistochemical, and biochemical results of this study demonstrated that Dexp has a protective effect against Cis-induced hepatotoxicity.

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“…Several studies demonstrated that free O 2 radicals caused renal damage. Furthermore, a number of studies showed free radical scavengers had useful effects on renal damage 14,15,16,17 .…”

Section: Histopathological Analysismentioning

confidence: 99%

Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats

Pınar

Karataş

Dağlıoğlu

et al. 2020

Cukurova Medical Journal

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We investigated the effects of Quercetin and Coenzyme Q 10 antioxidant, on gentamicin-induced renal failure in rats. Materials and Methods: The rats were given gentamicin (100 mg/kg/day, i.m., once a day), gentamicin (100 mg/kg/day, i.m.once a day) + Quercetin (15 mg/kg i.p. once a day) and gentamicin (100 mg/kg/day, i.m.) + Coenzyme Q 10 (8 mg/kg i.m. once a day). Results: In control the BUN value was 26.8 ± 0.8 (mg/100 mL); whereas, it was 117.3 ± 15.4 in gentamicin group. Renal histopathologic examination confirmed acute tubular necrosis in this group. In rats treated with gentamicin + Quercetin and gentamicin + Coenzyme Q 10 , a partial improvement in biochemical and histologic parameters was observed. BUN values were 117.3 ± 15.4, 44.0 ± 8.3, 47.8 ± 13.8 in gentamicin, gentamicin plus Quercetin and gentamicin plus Coenzyme Q 10 treated groups, respectively. Creatinine values were 4.3 ± 0.6, 0.8 ± 0.1, 1.5 ± 0.4 in gentamicin, gentamicin plus Quercetin and gentamicin plus Coenzyme Q 10 treated groups, respectively. Conclusion: These results suggest that the administration of Quercetin and Coenzyme Q 10 may have a protective effect on gentamicin-induced nephrotoxicity in rats. Amaç: Gentamisinle böbrek yetmezliği oluşturulan sıçanlarda Quercetin ve CoQ10 nun antioksidan etkilerini araştırmak amaçlanmıştır. Gereç ve Yöntem: Sıçanlara gentamicin (100 mg/kg/day, i.m., günde 1 kez), gentamicin (100 mg/kg/day, i.m.) + Quercetin (15 mg/kg i.p. günde 1 kez) and gentamicin (100 mg/kg/day, i.m.) + CoQ10 (8 mg/kg i.m. günde 1 kez) uygulandı. Bulgular: Kontrol grubundaki BUN değeri 26.8 ± 0.8 (mg/100 mL); buna karşın gentamisin grubunda 117.3 ± 15.4 bulunmuştur. Böbrek histopatolojik inceleme, bu grupta akut tübüler nekrozu doğruladı. Gentamicin + Quercetin ve gentamicin + CoQ10 uygulanan sıçanlarda biyokimyasal ve histolojik parametrelerde kısmi iyileşme gözlemlenmiştir. BUN değerleri gentamisin, gentamisin + Quercetin and gentamisin + CoQ10 gruplarında sırasıyla 117.3 ± 15.4, 44.0 ± 8.3, 47.8 ± 13.8 bulunmuştur. Gentamisin ile aralarında anlamlı farklılık bulunmuştur. Kreatinin değerleri gentamisin, gentamisin + Quercetin ve gentamisin + Koenzim Q10 ile tedavi edilen gruplarda sırasıyla 4.3 ± 0.6, 0.8 ± 0.1, 1.5 ± 0.4 idi. Sonuç: Bu sonuçlar Quercetin ve CoQ10 uygulanmasının gentamisinle nefrotoksisite oluşturulan sıçanlarda koruyucu etkisi olduğunu göstermiştir.

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Effects of dexpanthenol and N-acetylcysteine pretreatment in rats before renal ischemia/reperfusion injury

Abstract: We concluded that concomitant use of DXP and NAC plays a major role against I/R injury and may be useful in acute treatment of I/R induced renal failure.

Cited by 16 publications

References 20 publications

Additional effects of erythropoietin pretreatment, ischemic preconditioning, and N-acetylcysteine posttreatment in rat kidney reperfusion injury

Additional effects of erythropoietin pretreatment, ischemic preconditioning, and N-acetylcysteine posttreatment in rat kidney reperfusion injury

Protective effect of dexpanthenol against cisplatin‑induced hepatotoxicity

Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats

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