Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery

Hu, Xudong; Liu, Bing; Wu, Qing; Chen, Qingbiao; Lu, Pei; Huang, Jie; Liang, Xiaoxia; Cheng, Lan; Li, Yiqun

doi:10.2147/dddt.s326891

Cited by 8 publications

(6 citation statements)

References 55 publications

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“… 52 Studies have also found that dezocine maintains the balance of serum Th1/Th2 cytokines (INF-γ/IL-4) better than sufentanil in patients with gastric cancer surgery 64 and downregulates the expression of the TNF-α and IL-6 inflammatory factors in patients with liver cancer surgery. 65 Our studies also found that dezocine inhibits CRP levels 66 and maintains the CD3+/CD8+ balance, the IL-2/IL-10 cytokine balance 67 , 68 and the Th1/Th2 cell balance 69 in breast cancer patients undergoing surgery as compared to fentanyl or sufentanil. Interestingly, Dong et al found that the production of IFN-γ and PD-L1 decreases after treatment with 2 µg/mL dezocine but increases after treatment with 8 µg/mL dezocine in lung cancer cells, 70 suggesting that clinical doses of dezocine have immune upregulation effects but that large doses lead to immunosuppression, which is consistent with our previous findings.…”

Section: Dezocine Has Potential To Regulate the Clinical And Biologic...supporting

confidence: 57%

Dezocine Has the Potential to Regulate the Clinical and Biological Features of Tumors

Hu¹,

Liu²,

Qiu³

et al. 2022

DDDT

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Cancer is the second leading cause of death following ischemic heart disease in the world and the primary clinical, social and economic burden. Surgical resection is the main measure for the treatment of the vast majority of solid tumors. However, the recurrence and metastasis of tumors occur at different periods after surgery in many cases undergoing radical tumor surgery, which is the main cause of death of tumor patients. Moreover, tumor patients are prone to suffer from mental depression, which may increase the morbidity and mortality of tumors. Tumors have a series of clinical biological signs with the following five main features: postoperative pain and cancerous pain; suppression of antitumor immunity; angiogenesis in tumors; proliferation, growth and metastasis of tumors; and mental depression. Surgery is the first treatment in the majority of cancer patients with solid tumors. Opioids are required for anesthesia and postoperative analgesia. For cancerous pain control, patients undergo surgery, and their quality of life of is improved. However, traditional opioids, such as morphine, may inhibit antitumor immunity, induce vascular growth of tumors and promote the proliferation, invasion and migration of cancer cells, and traditional opioids can induce a risk of somatic dependence. However, studies have found that not all opioids share the effects of immunosuppression, tumor proliferation promotion and angiogenesis induction. Dezocine, a novel opioid with specific pharmacological mechanisms, has been demonstrated to regulate the five clinical and biological features of tumors. We reviewed the preclinical and clinical studies of dezocine on postoperative pain and cancer pain in tumor patients as well as the immune system, tumor angiogenesis, tumor proliferation, tumor growth, tumor metastasis and mental depression. We proposed that dezocine may be the best choice of opioids for anesthesia and analgesia in cancer patients.

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Section: Dezocine Has Potential To Regulate the Clinical And Biologic...supporting

confidence: 57%

Dezocine Has the Potential to Regulate the Clinical and Biological Features of Tumors

Hu¹,

Liu²,

Qiu³

et al. 2022

DDDT

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“…Th2 cells can promote B cell maturation, proliferation, and antibody production to exert anti-tumor effects [18]. We evaluated the role of Th2 cell-mediated activation of B cells in CRC.…”

Section: Plos Onementioning

confidence: 99%

Probiotic powder ameliorates colorectal cancer by regulating Bifidobacterium animalis, Clostridium cocleatum, and immune cell composition

Yang

Cao

et al. 2023

PLoS ONE

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Based on the relationship between the gut microbiota and colorectal cancer, we developed a new probiotic powder for treatment of colorectal cancer. Initially, we evaluated the effect of the probiotic powder on CRC using hematoxylin and eosin staining, and evaluated mouse survival rate and tumor size. We then investigated the effects of the probiotic powder on the gut microbiota, immune cells, and apoptotic proteins using 16S rDNA sequencing, flow cytometry, and western blot, respectively. The results showed that the probiotic powder improved the intestinal barrier integrity, survival rate, and reduced tumor size in CRC mice. This effect was associated with changes in the gut microbiota. Specifically, the probiotic powder increased the abundance of Bifidobacterium animalis and reduced the abundance of Clostridium cocleatum. In addition, the probiotic powder resulted in decreased numbers of CD4+ Foxp3+ Treg cells, increased numbers of IFN-γ+ CD8+ T cells and CD4+ IL-4+ Th2 cells, decreased expression of the TIGIT in CD4+ IL-4+ Th2 cells, and increased numbers of CD19+ GL-7+ B cells. Furthermore, the expression of the pro-apoptotic protein BAX was significantly increased in tumor tissues in response to the probiotic powder. In summary, the probiotic powder ameliorated CRC by regulating the gut microbiota, reducing Treg cell abundance, promoting the number of IFN-γ+ CD8+ T cells, increasing Th2 cell abundance, inhibiting the expression of TIGIT in Th2 cells, and increasing B cell abundance in the immune microenvironment of CRC, thereby increasing the expression of BAX in CRC.

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“…Accumulating evidence suggests that the selection of anaesthetic drugs, approaches and time can exert diverse repercussions on the immune system. For instance, intravenous injection of dezocine can elevate the Th1/Th2 cell ratio after breast cancer surgery 97 . The ratio of Th1/Th2 cells is associated with tumour growth, metastasis and survival, and the shift to Th1 cells tends to usher in a more desired immune response against cancer 98 .…”

Section: Anticancer Immune Response Outside the Tumourmentioning

confidence: 99%

“…For instance, intravenous injection of dezocine can elevate the Th1/Th2 cell ratio after breast cancer surgery. 97 The ratio of Th1/Th2 cells is associated with tumour growth, metastasis and survival, and the shift to Th1 cells tends to usher in a more desired immune response against cancer. 98 These findings suggest an underappreciated role of anaesthesia in cancer immune response, which warrants further investigation.…”

Section: Anticancer Immune Response Outside the Tumourmentioning

confidence: 99%

Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems

Zhang

Gao

et al. 2023

Clinical & Translational Med

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Background The immune system plays a pivotal role in the initiation, evolution, invasion and metastasis of cancer. Therapeutics aiming at modulating or boosting anticancer immune responses have experienced immense advances during the past decades, for example, anti‐PD‐1/PD‐L1 monoclonal antibodies. Main body Concomitant with advancements in the understanding of novel mechanisms of action, conventional or emerging drugs bearing the potential to be repurposed for enhancing anticancer immunity have been identified. Meanwhile, ongoing advances in drug delivery systems enable us to utilise novel therapeutic strategies and impart drugs with fresh modes of action in tumour immunology. Conclusion Herein, we systemically review these kinds of drugs and delivery systems that can unleash the anticancer response through various aspects, including immune recognition, activation, infiltration and tumour killing. We also discuss the current caveats and future directions of these emerging strategies.

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Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery

Cited by 8 publications

References 55 publications

Dezocine Has the Potential to Regulate the Clinical and Biological Features of Tumors

Dezocine Has the Potential to Regulate the Clinical and Biological Features of Tumors

Probiotic powder ameliorates colorectal cancer by regulating Bifidobacterium animalis, Clostridium cocleatum, and immune cell composition

Enhancing the anticancer immune response with the assistance of drug repurposing and delivery systems

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