Effects of di-isopropylfluorophosphate and isopropanol on the measurement of plasma renin activity

Chen, Teh-Chung; Weber, Michael A.

doi:10.1016/0009-8981(80)90449-0

Cited by 2 publications

(2 citation statements)

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“…Inactive plasma renin (prorenin), as measured by cryoactivation [11], did not change during this acute study with captopril. Thus, total plasma renin (plasma renin activity plus inactive renin) rose solely by virtue of the increase in the active plasma renin.…”

Section: Discussionmentioning

confidence: 99%

“…Plasma aldosterone also was measured by radioimmunoassay [10]. Additionally, in samples drawn from patients in the supine posture, inactive renin (prorenin) measurements were performed by cryoactivation [11], a method which is reproducible but which may not measure the total potential inactive renin. Statistical analysis for the significance of changes or differences was by the Wilcoxon (non-parametric) method, and esti mation of correlations between measurements was by the Spearman (non-parametric) method.…”

Section: Methodsmentioning

confidence: 99%

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Participation of the Renin System in Treatment-Resistant Hypertension as Measured by Acute Blockade of the Angiotensin Converting Enzyme

Weber¹,

Drayer²,

Priest³

et al. 1982

Am J Nephrol

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The acute blood pressure response to the angiotensin converting enzyme inhibitor, captopril, was used to measure participation of the renin-angiotensin system in treatment-resistant hypertension. By 2 h after a single 25-mg oral captopril dose in patients still receiving a diuretic-vasodilator-beta-blocker combination, systolic and diastolic blood pressures had fallen significantly; the decrease in diastolic pressure correlated with the control (immediately pre-captopril) plasma renin activity (r = 0.64, p < 0.001). Apart from its possible contribution to the underlying hypertension, this captopri-identified renin component may have reflected diuretic and vasodilator-induced renin stimulation that could not adequately be prevented by the renin-lowering properties of the beta-blocker. Captopril, and perhaps other specific antirenin drugs, therefore, may be valuable adjuncts to treatment in patients with hypertension refractory to conventional therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%