Effects of Diabetes Mellitus on the Biomechanical Properties of Human Ankle Cartilage

Athanasiou, K. A.; Fleischli, John G.; Bosma, Jark J.D.; Laughlin, Terese J.; Zhu, C. F.; Agrawal, C. Mauli; Lavery, Lawrence A.

doi:10.1097/00003086-199911000-00022

Cited by 28 publications

(21 citation statements)

References 44 publications

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“…The higher aggregate modulus and lower hydraulic permeability observed in ankle cartilage has been attributed to the lower proteoglycan content. 13,34,40,41 Another hypothesis for the lower incidence of ankle arthritis is that the cartilage is stiffer and the cells are shielded from the mechanical stress that the knee chondrocytes experience. In fact, because the same component (proteoglycan content) is likely to underlie differences in both transport and mechanical properties, it is plausible that they both play a role in shielding the ankle from developing arthritis.…”

Section: Discussionmentioning

confidence: 99%

Composition and transport properties of human ankle and knee cartilage

Fetter

Leddy

Guilak

et al. 2005

Journal Orthopaedic Research

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ABSTRACT:The incidence of osteoarthritis is significantly higher in the knee as compared to the ankle, suggesting that differences in the properties of cartilage from these joints may contribute to the development of osteoarthritis. As an avascular tissue, articular cartilage depends primarily upon diffusion for molecular transport. The goal of this study was to determine if differences in the structure and composition between ankle and knee cartilage were also reflected as differences in solute transport properties. The diffusion coefficient and partition coefficient of a 70-kDa dextran molecule were measured in human ankle and knee articular cartilage using fluorescence recovery after photobleaching (FRAP) and were compared to the proteoglycan, collagen, water, and DNA contents within each zone. The mean partition coefficient was significantly lower in the ankle compared to the knee (0.010 AE 0.002 vs. 0.022 AE 0.003, p < 0.01), but no differences in the diffusion coefficients were observed (34.6 AE 0.9 mm 2 s À1 vs. 35.4 AE 2.4 mm 2 s À1 , p ¼ 0.70). Ankle cartilage exhibited higher proteoglycan content as well as a trend toward lower water content, suggesting that ankle cartilage has a smaller effective pore size than knee cartilage. These findings suggest that differences in the composition of ankle and knee cartilage contribute to a difference in the partition coefficient. The results of this study provide further support for the hypothesis that the transport properties of cartilage may play a role in the differences in the incidence of osteoarthritis in these joints by altering the effective concentration of growth factors and cytokines to which chondrocytes are exposed. ß

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Section: Discussionmentioning

confidence: 99%

Composition and transport properties of human ankle and knee cartilage

Fetter

Leddy

Guilak

et al. 2005

Journal Orthopaedic Research

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“…Exclusion criteria were: age <18 years, defect size >20 mm, ankle osteoarthritis grade III, 426 concomitant ankle pathology (tibial osteochondral defect, ankle instability, or ankle fracture), advanced osteoporosis, infection, a known allergy to implant material, and diabetes mellitus (because diabetes is associated with increased risk of infection as well as soft er and more permeable talar cartilage). 25 All patients provided informed consent.…”

Section: Methodsmentioning

confidence: 99%

“…There may be a normal range of motion, with the absence of swelling and absence of recognizable tenderness on palpation. 25 …”

Section: Clinical Presentationmentioning

confidence: 99%

Treatment of osteochondral defects of the talus

Bergen

Leeuw

Dijk

2008

Revue de Chirurgie Orthopédique et Réparatrice de l'Appareil Mo

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“…The material properties of all tissues were assigned according to previous simulations or experimental reports [2, [12][13][14][16][17][18][19][20][21]. Bones and cartilages were idealized as being homogeneous, isotropic, and linearly elastic.…”

Section: Finite Element Modelingmentioning

confidence: 99%

“…Bones and cartilages were idealized as being homogeneous, isotropic, and linearly elastic. The Young's modulus and Poisson ratio of bones were chosen as 7.3 GPa and 0.3 respectively [2, [16][17][18]. According to experimental measurements, the ankle joint and inter-foot joints had different material properties and cartilages thicknesses.…”

Section: Finite Element Modelingmentioning

confidence: 99%

An in vitro and finite element study of load redistribution in the midfoot

Niu

Tang²,

Zhang

et al. 2014

Sci. China Life Sci.

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A good knowledge of midfoot biomechanics is important in understanding the biomechanics of the entire foot, but it has never been investigated thoroughly in the literature. This study carried out in vitro experiments and finite element analysis to investigate the midfoot biomechanics. A foot-ankle finite element model simulating the mid-stance phase of the normal gait was developed and the model validated in in vitro experimental tests. Experiments used seven in vitro samples of fresh human cadavers. The simulation found that the first principal stress peaks of all midfoot bones occurred at the navicular bone and that the tensile force of the spring ligament was greater than that of any other ligament. The experiments showed that the longitudinal strain acting on the medial cuneiform bone was 26.2±10.8 -strain, and the navicular strain was 240.0±169.1 -strain along the longitudinal direction and 65.1±25.8 µ-strain along the transverse direction. The anatomical position and the spring ligament both result in higher shear stress in the navicular bone. The load from the ankle joint to five branches of the forefoot is redistributed among the cuneiforms and cuboid bones. Further studies on the mechanism of loading redistribution will be helpful in understanding the biomechanics of the entire foot. finite element analysis, foot arch, biomechanics, cadaveric experiment, midfoot Citation:Niu WX, Tang TT, Zhang M, Jiang CH, Fan YB. An in vitro and finite element study of load redistribution in the midfoot.

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Effects of Diabetes Mellitus on the Biomechanical Properties of Human Ankle Cartilage

Cited by 28 publications

References 44 publications

Composition and transport properties of human ankle and knee cartilage

Composition and transport properties of human ankle and knee cartilage

Treatment of osteochondral defects of the talus

An in vitro and finite element study of load redistribution in the midfoot

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