Effects of dialkoxylphenyl compounds with oxime group on macrophage function and the proliferation of lymphocytes

Yoo, Eun Sook; Son, H J; Park, Joon Seok; Kim, Ae Ra; Baik, Kyong Up; Park, Myung Hwan; Cho, Jae Youl

doi:10.1211/0022357023042

Cited by 7 publications

(4 citation statements)

References 38 publications

(46 reference statements)

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“…Using ovalbumin-induced allergic asthma model, Kwon et al demonstrated benzofuran derivatives significantly reduced the levels of IL-5, IL-13 and IgE production, eosinophils and macrophages influx, ICAM-1/MCP-1 expression, mucus secretion and airway hyperresponsiveness in mice, suggesting benzofuran exerts protective effect to airway inflammation. Similarly, methoxy-phenyl-oxime derivatives have demonstrated anti-inflammatory activities [28] and dimethyl selenide derivatives alters interleukin-4/13 signalling pathways in vitro [29]. Other previously unreported compounds should be subjected to further investigation into their potential roles in asthma exacerbation and airway inflammation.…”

Section: Summary Of Resultsmentioning

confidence: 99%

Changes in exhaled volatile organic compounds following indirect bronchial challenge in suspected asthma

Peel¹,

Wang²,

Ahmed³

et al. 2023

Thorax

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BackgroundInhaled mannitol provokes bronchoconstrictionviamediators released during osmotic degranulation of inflammatory cells, and, hence represents a useful diagnostic test for asthma and model for acute attacks. We hypothesised that the mannitol challenge would trigger changes in exhaled volatile organic compounds (VOCs), generating both candidate biomarkers and novel insights into their origin.MethodsParticipants with a clinical diagnosis of asthma, or undergoing investigation for suspected asthma, were recruited. Inhaled mannitol challenges were performed, followed by a sham challenge after 2 weeks in participants with bronchial hyper-responsiveness (BHR). VOCs were collected before and after challenges and analysed using gas chromatography–mass spectrometry.ResultsForty-six patients (mean (SD) age 52 (16) years) completed a mannitol challenge, of which 16 (35%) were positive, and 15 of these completed a sham challenge. Quantities of 16 of 51 identified VOCs changed following mannitol challenge (p<0.05), of which 11 contributed to a multivariate sparse partial least square discriminative analysis model, with a classification error rate of 13.8%. Five of these 16 VOCs also changed (p<0.05) in quantity following the sham challenge, along with four further VOCs. In patients with BHR to mannitol distinct postchallenge VOC signatures were observed compared with post-sham challenge.ConclusionInhalation of mannitol was associated with changes in breath VOCs, and in people with BHR resulted in a distinct exhaled breath profile when compared with a sham challenge. These differentially expressed VOCs are likely associated with acute airway inflammation and/or bronchoconstriction and merit further investigation as potential biomarkers in asthma.

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Section: Summary Of Resultsmentioning

confidence: 99%

Changes in exhaled volatile organic compounds following indirect bronchial challenge in suspected asthma

Peel¹,

Wang²,

Ahmed³

et al. 2023

Thorax

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“…Oxime-based phosphodiesterase (PDE) 4 inhibitors are also being evaluated as potential anti-inflammatory agents, as they have the ability to inhibit the production of inflammatory mediators and cytokines [ 185 ]. Several oxime derivatives of rolipram, an inhibitor of PDE4, have been reported to inhibit TNF production in LPS-stimulated RAW264.7 macrophages with higher potency than rolipram [ 186 ]. Interestingly, the E / Z -geometry of oxime was important for activity of these compounds, with cis -isomers being more active than the corresponding trans -isomers [ 186 ].…”

Section: Oximes With Non-kinase Targetsmentioning

confidence: 99%

“…Several oxime derivatives of rolipram, an inhibitor of PDE4, have been reported to inhibit TNF production in LPS-stimulated RAW264.7 macrophages with higher potency than rolipram [ 186 ]. Interestingly, the E / Z -geometry of oxime was important for activity of these compounds, with cis -isomers being more active than the corresponding trans -isomers [ 186 ].…”

Section: Oximes With Non-kinase Targetsmentioning

confidence: 99%

Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential

et al. 2021

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Oximes have been studied for decades because of their significant roles as acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have been reported with useful pharmaceutical properties, including compounds with antibacterial, anticancer, anti-arthritis, and anti-stroke activities. Many oximes are kinase inhibitors and have been shown to inhibit over 40 different kinases, including AMP-activated protein kinase (AMPK), phosphatidylinositol 3-kinase (PI3K), cyclin-dependent kinase (CDK), serine/threonine kinases glycogen synthase kinase 3 α/β (GSK-3α/β), Aurora A, B-Raf, Chk1, death-associated protein-kinase-related 2 (DRAK2), phosphorylase kinase (PhK), serum and glucocorticoid-regulated kinase (SGK), Janus tyrosine kinase (JAK), and multiple receptor and non-receptor tyrosine kinases. Some oximes are inhibitors of lipoxygenase 5, human neutrophil elastase, and proteinase 3. The oxime group contains two H-bond acceptors (nitrogen and oxygen atoms) and one H-bond donor (OH group), versus only one H-bond acceptor present in carbonyl groups. This feature, together with the high polarity of oxime groups, may lead to a significantly different mode of interaction with receptor binding sites compared to corresponding carbonyl compounds, despite small changes in the total size and shape of the compound. In addition, oximes can generate nitric oxide. This review is focused on oximes as kinase inhibitors with anticancer and anti-inflammatory activities. Oximes with non-kinase targets or mechanisms of anti-inflammatory activity are also discussed.

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“…Similarly, Cordyceps militaris extract exhibits anti-inflammatory activity by reducing the production and expression of inflammatory mediators in DSS-induced mice with acute colitis [18]. Cordyceps militaris extract is effective in the alleviation of oxidative-stressinduced apoptosis and premature ageing, the inhibition of cancer cell proliferation and the treatment of metabolic disorders caused by obesity [19][20][21]. Although previous research has indicated that cordycepin and Cordyceps militaris extract could modulate the composition of the gut microbiota, the potential mechanisms by which Cordyceps militaris extract and cordycepin regulate the association between intestinal inflammation and the gut microbiota remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Cordyceps militaris Extract and Cordycepin Alleviate Oxidative Stress, Modulate Gut Microbiota and Ameliorate Intestinal Damage in LPS-Induced Piglets

Xiong,

Jiang,

Wan

et al. 2024

Antioxidants

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Cordycepin is considered a major bioactive component in Cordyceps militaris extract. This study was performed to evaluate the ameliorative effect of Cordyceps militaris extract (CME) and cordycepin (CPN) supplementation on intestinal damage in LPS-challenged piglets. The results showed that CPN or CME supplementation significantly increased the villus height (p < 0.01) and villus height/crypt depth ratio (p < 0.05) in the jejunum and ileum of piglets with LPS-induced intestinal inflammation. Meanwhile, CPN or CME supplementation alleviated oxidative stress and inflammatory responses by reducing the levels of MDA (p < 0.05) and pro-inflammatory cytokines in the serum. Additionally, supplementation with CPN or CME modulated the structure of the intestinal microbiota by enriching short-chain fatty acid-producing bacteria, and increased the level of butyrate (p < 0.05). The RNA-seq results demonstrated that CME or CPN altered the complement and coagulation-cascade-related genes (p < 0.05), including upregulating gene KLKB1 while downregulating the genes CFD, F2RL2, CFB, C4BPA, F7, C4BPB, CFH, C3 and PROS1, which regulate the complement activation involved in inflammatory and immune responses. Correlation analysis further demonstrated the potential relation between the gut microbiota and intestinal inflammation, oxidative stress, and butyrate in piglets. In conclusion, CPN or CME supplementation might inhibit LPS-induced inflammation and oxidative stress by modulating the intestinal microbiota and its metabolite butyrate in piglets.

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Effects of dialkoxylphenyl compounds with oxime group on macrophage function and the proliferation of lymphocytes

Cited by 7 publications

References 38 publications

Changes in exhaled volatile organic compounds following indirect bronchial challenge in suspected asthma

Changes in exhaled volatile organic compounds following indirect bronchial challenge in suspected asthma

Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential

Cordyceps militaris Extract and Cordycepin Alleviate Oxidative Stress, Modulate Gut Microbiota and Ameliorate Intestinal Damage in LPS-Induced Piglets

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