Effects of diarylbutane lignans from Schisandra chinensis fruit on SARS-CoV-2 3CLpro and PLpro and their in vitro anti-inflammatory properties

Li, Bin; Qiao, Liansheng; Xiao, Qi; Zhang, Jinuo; Liu, Jiushi; Zhang, Bengang; Liu, Haitao

doi:10.1016/j.phyplu.2023.100432

Cited by 7 publications

(2 citation statements)

References 18 publications

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“…Lignans are the main active substance of SS, which has hepatoprotective, antitumor, cough, neuroprotective, antiinflammatory, and other pharmacological effects [15][16][17].…”

Section: Cleavage Patterns Of Lignansmentioning

confidence: 99%

Rapid identification of chemical compositions of three species of Schisandra chinensis by ultra‐high‐performance liquid chromatography quadrupole‐orbitrap‐mass spectrometry

Shu,

Qiu,

Zhang

et al. 2023

J of Separation Science

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Schisandra chinensis is a traditional Chinese medicine, which has played an important role in the field of medicine and food. In this study, ultra‐high‐performance liquid chromatography quadrupole‐orbitrap‐mass spectrometry was used to rapidly classify and identify the chemical compositions. Note that 32, 28, and 30 kinds of compounds were successfully identified from northern Schisandra chinensis, vinegar‐processed Schisandra chinensis, and wine‐processed Schisandra chinensis, respectively. The cleavage patterns of various components including lignans, organic acids, flavonoids, and terpenoids were summarized, and the effects of different processing methods on Schisandra chinensis were analyzed through chemical composition. This method realized the rapid classification and identification of raw Schisandra chinensis and two different processed products, and provided references for improving the traditional processing methods, strengthening quality control, and ensuring safe clinical application.

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“…Lignans are the main active substance of SS, which has hepatoprotective, antitumor, cough, neuroprotective, antiinflammatory, and other pharmacological effects [15][16][17].…”

Section: Cleavage Patterns Of Lignansmentioning

confidence: 99%

Rapid identification of chemical compositions of three species of Schisandra chinensis by ultra‐high‐performance liquid chromatography quadrupole‐orbitrap‐mass spectrometry

Shu,

Qiu,

Zhang

et al. 2023

J of Separation Science

View full text Add to dashboard Cite

show abstract

“…Lignans are the main active substance of Schisandra chinensis, which has hepatoprotective, antitumor, cough, neuroprotective, anti-inflammatory and other pharmacological effects. 14,15 Lignans are the main active ingredients in Schisandra chinensis. Based on the parent nucleus structure, lignans were divided into biphenyl cyclooctene lignans and open-loop lignans.…”

Section: Cleavage Patterns Of Lignansmentioning

confidence: 99%

Rapid identification of three species of Schisandra chinensis based on UPLC-Q-Orbitrap-MS technique and characteristic fragments

Shu

Qiu

et al. 2023

Preprint

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Rationale: Schisandra chinensis is a traditional Chinese medicine in China. Based on the ultra-performance liquid chromatography quadrupole-Orbitrap-mass spectrometry (UPLC-Q-Orbitrap-MS) technique, we rapidly identified the components of Northern Schisandra chinensis(SS), Schisandrae Chinensis Fructus processed with vinegar(CS), Wine-processed Schisandra chinensis(JS), and distinguished the differences of the chemical composition of the three Schisandra chinensis before and after processing, to provide a reference for rational clinical use. Methods: In this study, used the UPLC-Q-Orbitrap-MS and data post-processing techniques. Based on the literature summarizing the fragmentation information of possible characteristic fragments(CFs) and related neutral losses (NLs)of lignans, organic acids, flavonoids, terpenoids and other components of Schisandra chinensis, then by comparing with the mass spectrum data obtained from the detection, to achieve rapid classification and identification of SS, CS and JS. Results: In this study, 51, 41 and 42 compounds were successfully identified from SS, CS and JS, respectively. The composition of Schisandra chinensis differs before and after processing, the realization of the distinction between the three traditional Chinese medicines. Conclusions: In this study, to distinguish SS, CS and JS in terms of chemical composition differences. It can achieve the rapid classification and identification of different processing technology of Schisandra chinensis and provide a reference for safer and rational clinical application.

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The extraction, purification, structural features, bioactivities, and applications of Schisandra chinensis polysaccharides: A review

Luan,

Zou,

Zhang

et al. 2024

International Journal of Biological Macromolecules

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Effects of diarylbutane lignans from Schisandra chinensis fruit on SARS-CoV-2 3CLpro and PLpro and their in vitro anti-inflammatory properties

Cited by 7 publications

References 18 publications

Rapid identification of chemical compositions of three species of Schisandra chinensis by ultra‐high‐performance liquid chromatography quadrupole‐orbitrap‐mass spectrometry

Rapid identification of chemical compositions of three species of Schisandra chinensis by ultra‐high‐performance liquid chromatography quadrupole‐orbitrap‐mass spectrometry

Rapid identification of three species of Schisandra chinensis based on UPLC-Q-Orbitrap-MS technique and characteristic fragments

The extraction, purification, structural features, bioactivities, and applications of Schisandra chinensis polysaccharides: A review

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