Effects of Diatomaceous earth in amelioration of Aflatoxin induced patho-morphological changes in broilers

Lakkawar, A.W.; Sathyanarayana, M. L.; Narayanaswamy, H.D.; Yathiraj, S.; Shridhar, N. B.; Krishnaveni, N.

doi:10.5958/0973-970x.2015.00035.8

Cited by 5 publications

(7 citation statements)

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“…The increased weight of kidneys in the present study corresponded with earlier findings, which could be attributed to vascular reaction and degenerative changes in renal parenchyma following aflatoxicosis (Valchev et al, 2013;Yalagod, 2014;Lakkawar et al, 2015). In the present study, the relative weights of thymus, spleen and bursa of Fabricius significantly (p≤ 0.05) decreased in aflatoxin fed birds (Figure 3, 4, 5) and corresponded with earlier reports (Ortatatli and Oguz, 2001;Kumar et al, 2014;Yalagod, 2014;Lakkawar et al, 2015).…”

Section: Resultssupporting

confidence: 92%

“…The data furnished in Figure 1 indicatesignificant (p≤ 0.05) increase in the relative weight of liver in aflatoxin treated birds, which corroborated with the earlier reports (Ortatatli et al, 2005;Shi et al, 2006;Denli et al, 2009;Khan et al, 2010;Yalagod, 2014;Lakkawar et al, 2015), which could be attributed to the aflatoxin induced impaired fat metabolism leading to increased accumulation of lipids in the hepatocytes. The hepatic lipidosis is primarily mediated through inhibition of phospholipids synthesis and cholesterol.…”

Section: Resultssupporting

confidence: 89%

“…This in-turn affects the transportation of lipid from the liver (Hsieh, 1979). In addition, vascular, degenerative and inflammatory changes incited by AF in visceral organs might be responsible for increased weights and this observation drew support from the histopathological lesions of severe fatty change, lipidosis and inflammatory reaction reported in an earlier study (Lakkawar et al, 2015).…”

Section: Resultssupporting

confidence: 74%

“…Losses associated with consumption of AF-contaminated foodstuff in the poultry include growth retardation, decreased feed intake, biochemical alterations, patho-morphological changes in various organs, increased mortality, decreased egg production, and carcass condemnation (Khan et al, 2010;Lakkawar et al, 2015;. Aflatoxins at varying dose levels are also known to cause alterations in relative organ weights.…”

Section: Resultsmentioning

confidence: 99%

“…Aflatoxins at varying dose levels are also known to cause alterations in relative organ weights. A significant alteration in the relative weight of various visceral and lymphoid organs is one of the important toxic effects of aflatoxicosis in chicken (Lakkawar et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

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Study on Efficacy of Diatomaceous Earth to Ameliorate Toxic Effects of Aflatoxin on Internal Organ Weights in Broiler Chicken

Lakkawar¹,

Narayanaswamy²,

Satyanarayana³

2017

J. Anim. Health Prod.

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Aflatoxins are secondary metabolites and a class of mycotoxins produced predominantly by Aspergillus flavus and A.parasiticus. These toxins are present worldwide in feeds and cause severe economic lossesto the poultry and livestock industries (Miller, 1995). Studies showed the adverse effects of aflatoxin in broiler chickens including decrease in body weight gain, efficiency of feed utilization, alteration in serum biochemical parameters, relative weights of visceral and lymphoid organs, immune responses and pathological changes in various organs (Ortatatli et al., 2005;Shi Research Article Abstract | Diatomaceous earth (DAE) is an abundantly available clay, rich in a morphous silica that have light weight, highly porous and super-absorbent nature. The ability of DAE in reducing the adverse effects of aflatoxin (AF) in broiler diet was evaluated. A total of 240 healthy day old broiler chicks were divided into 6 groups (n= 40 per group), comprising of control and treatment groups. Group I and II was served as negative and positive control respectively. The groups III and IV were given 1 and 0.5 ppm of AF Kg -1 of feed respectively, while groups V and VI were both supplemented DAE @ 2000 mg Kg -1 of feed along with 1 and 0.5 ppm of AF Kg -1 of feed, respectively. Feeding of AF resulted in significant increase (p< 0.05) in the relative weight of liver, kidneys and heart in comparison to the control groups. However, the relative weight of thymus, spleen and bursa was found to be decreased (p< 0.05) in the aflatoxin fed birds. The addition of DAE to the aflatoxin mixed feed significantly improved the relative organ weight and decreased the severity of lesions in the visceral and lymphoid organs. The study concluded that DAE can be effectively used to decrease the toxic effects of AF in broiler chicken.

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Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 89%

Section: Resultssupporting

confidence: 74%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Study on Efficacy of Diatomaceous Earth to Ameliorate Toxic Effects of Aflatoxin on Internal Organ Weights in Broiler Chicken

Lakkawar¹,

Narayanaswamy²,

Satyanarayana³

2017

J. Anim. Health Prod.

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Effects of aflatoxin B1 on histopathological structure of immunocompetent organs in mulard ducks

Groseva¹,

Valchev²,

Hristov³

et al. 2019

AST

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Abstact. The aim of the present experiment was to investigate the toxic effects of aflatoxin В1 (AFB1) on immunocompetent organs (thymus, spleen, bursa of Fabricius) morphology. Also, the possibility for prevention of toxic effects of AFB1 by feed supplementation of a mycosorbent (Mycotox NB) was studied. The experiments were conducted with 4 groups of 20 10-day-old mulard ducks: group I – control, fed a standard compound feed according to the species and the age; group II – experimental, whose feed was supplemented with 0.5 mg/kg. AFB1, group III – experimental, supplemented with 0.8 mg/kg AFB1 and group IV – experimental, supplemented with 0.5 mg/kg AFB1 and 2 g/kg Mycotox NG. The duration of the experiments was 42 days. Atrophy and degenerative changes were observed in immunocompetent organs of birds from groups ІІ and III. The supplementation of the feed with 2 g/kg Mycotox NG resulted in partial neutralisation of deleterious effects of AFB1 on severity of histological lesions (considerably slighter lymphoid follicle rarefaction).

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Influence on Mycotox® NG effects on relative weights of some internal organs in Pekin ducks with experimentally reproduced aflatoxicosis В1

Valchev¹,

Stojanchev²,

Binev³

2021

AST

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Abstract. Contamination of poultry feeds with mycotoxins is a global problem faced by poultry industry due to increased demands and availability of poor-quality cereals. The aim of the present study was to evaluate the beneficial effects of a mycotoxin binder (Mycotox NG) on relative weights of internal organs in Pekin ducks with experimental aflatoxicosis. The birds were divided into one control and six experimental groups (n=10) as follows: group І (0 mg/kg AFB1 without Mycotox NG); group ІI (0.5 g/kg Mycotox NG); group ІІI (1.0 g/kg Mycotox NG); group IV (0.2 mg/kg AFB1); group V (0.4 mg/kg AFB1); group VI (0.2 mg/kg AFB1 + 0.5 g/kg Mycotox NG) and group VII (0.4 mg/kg AFB1 + 1.0 g/kg Mycotox NG). Trial duration was 42 days. It was established that ducks fed AFB1-contaminated feed had increased relative weights of liver, kidneys, pancreas, heart, gizzard and proventriculus compared to the control group. At the same time, the relative weights of immunocompetent organs (thymus, spleen and bursa of Fabricius) were reduced. The addition of Mycotox NG to the feed contaminated with AFB1 compensated partly the changes in relative weights of visceral organs. The results from the present study demonstrated that the tested toxin binder could be effective for reduction of toxic effects of aflatoxins in domestic ducks.

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Effects of Diatomaceous earth in amelioration of Aflatoxin induced patho-morphological changes in broilers

Cited by 5 publications

References 0 publications

Study on Efficacy of Diatomaceous Earth to Ameliorate Toxic Effects of Aflatoxin on Internal Organ Weights in Broiler Chicken

Study on Efficacy of Diatomaceous Earth to Ameliorate Toxic Effects of Aflatoxin on Internal Organ Weights in Broiler Chicken

Effects of aflatoxin B1 on histopathological structure of immunocompetent organs in mulard ducks

Influence on Mycotox® NG effects on relative weights of some internal organs in Pekin ducks with experimentally reproduced aflatoxicosis В1

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