Effects of Diazepam, Piracetam, and Mexidol on Passive Avoidance Response

Иноземцев, А. Н.; Berezhnoy, D. S.; Novoseletskaya, A. V.

doi:10.3103/s0096392519040047

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…Thus, the antioxidant mexidol reduced the latent period but increased the choice of a safe compartment (in a 3-chamber setup), in which the rats were not subjected to electric shock the day before. This indicates the formation of a memory trace about the place of electric shock application under the effects of mexidol [16].…”

Section: Resultsmentioning

confidence: 85%

Comparison of the effects of amitriptyline, melipramine and fluoxetine on acquisition and spatial alteration of avoidance responses in rats

Inozemtsev,

Hashimova,

Lovat

et al. 2023

Azerbaijan Journal of Physiology

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The effects of amitriptyline (10 mg/kg), melipramine (10 mg/kg), and fluoxetine (5 mg/kg) on the acquisition of conditioned active avoidance responses and their spatial alteration in rats were studied. During the acquisition of avoidance, a passage in the partition was open, adjacent to the rear wall of the shuttle chamber. On the 5th experimental day after the end of the training, this distal opening was closed and the proximal one was opened, after which avoidance performance under changed conditions was tested for 20 trials. Melipramine and amitriptyline accelerated the acquisition of avoidance responses. Changing the location of the opening disrupted the learned skill, especially in the control animals. Melipramine and fluoxetine statistically significantly (in contrast to amitriptyline) accelerated the recovery of the level of avoidance. The positive effect of melipramine and fluoxetine is explained by a psychostimulating component in their spectrum. The inability of amitriptyline to produce a significant effect in this model is due to its psychosedative properties. The data obtained allow us to conclude that the acquisition of the active conditioned avoidance responses and their spatial modification can be used to analyze the antidepressant activity of pharmacological agents.

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Section: Resultsmentioning

confidence: 85%

Comparison of the effects of amitriptyline, melipramine and fluoxetine on acquisition and spatial alteration of avoidance responses in rats

Inozemtsev,

Hashimova,

Lovat

et al. 2023

Azerbaijan Journal of Physiology

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A Review on Synthesis and Pharmacological Activities of Piracetam and its Derivatives

et al. 2021

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Piracetam is generally utilized as a nootropic drug, which is normally used in the treatment of CNS disorders. Piracetam is a cyclic compound and a derivative of γ-aminobutyric acid and improves learning, memory, brain metabolism, and ability. This drug belongs to the racetams group with the chemical name 2-oxo-1-pyrrolidine acetamide. The emphasis of this review article is to highlight different biological activities associated with piracetam and also some of its synthetic methodologies. Promising effects have been achieved in the management and treatment of several diseases for example alcoholism, Raynaud’s phenomenon, deep vein thrombosis and brain injury.

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Synthesis, Characterization, Docking Studies and Antiepileptic Activity of Novel Piracetam Derivatives

et al. 2023

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Piracetam is a nootropic drug that has been used in clinical trials for decades, but is still a mystery due to a lack of understanding of its mechanism of action. In this research, sixteen novel piracetam derivatives were synthesized in three steps and characterized by IR, NMR and mass spectroscopic techniques. Based on the docking studies, two derivatives were identified as more active based on the drug receptor interactions studies and were further subjected to animal studies for the evaluation of the activity. Compounds 6 and 10 had shown a strong anticonvulsant activity based on the molecular docking studies. It was hypothesized from the synthesized analogues that the non-substitution with thio moiety at has a major effect on reducing the contagiousness of seizure discharge and increasing the seizure threshold.

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Effects of Diazepam, Piracetam, and Mexidol on Passive Avoidance Response

Cited by 4 publications

References 17 publications

Comparison of the effects of amitriptyline, melipramine and fluoxetine on acquisition and spatial alteration of avoidance responses in rats

Comparison of the effects of amitriptyline, melipramine and fluoxetine on acquisition and spatial alteration of avoidance responses in rats

A Review on Synthesis and Pharmacological Activities of Piracetam and its Derivatives

Synthesis, Characterization, Docking Studies and Antiepileptic Activity of Novel Piracetam Derivatives

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