Effects of dibutyryl cAMP on growth performance and carcass traits in finishing pigs

Wang, L.; Zhi, Jiang; Lin, Yingcai; Zheng, Chuntian; Jiang, Shan; Ma, Xianyong

doi:10.1016/j.livsci.2012.02.024

Cited by 6 publications

(9 citation statements)

References 35 publications

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“…At slaughter, carcass weight was recorded after evisceration so that carcass yields could be calculated. The other carcass traits (obtained from the left side of the carcass) including carcass length, loin muscle area, average backfat thickness of first-and last-rib and last-lumbar vertebra were measured by the previous methods [20].…”

Section: Carcass Trait and Meat Quality Measurementsmentioning

confidence: 99%

Meat Quality and Fatty Acid Profiles of Chinese Ningxiang Pigs Following Supplementation with N-Carbamylglutamate

Xing

Xie

et al. 2020

Animals

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The present study evaluated the effects of dietary N-carbamylglutamate (NCG) on carcass traits, meat quality, and fatty acid profiles in the longissimus dorsi muscle and adipose tissues of Chinese Ningxiang pigs. A total of 36 castrated female pigs with a similar initial weight (43.21 ± 0.57 kg) were randomly assigned to two treatments (with six pens per treatment and three pigs per pen) and fed either a basal diet or a basal diet supplemented with 0.08% NCG for 56 days. Results showed that dietary NCG reduced shear force (p = 0.004) and increased drip loss (p = 0.044) in longissimus dorsi muscle of Ningxiang pigs. Moreover, increased levels of oleic acid (C18:1n9c) (p = 0.009), paullinic acid (C20:1) (p = 0.004), and α-linolenic acid (C18:3n3) (p < 0.001), while significant reduction in the proportions of arachidonic acid (C20:4n6) (p < 0.001) and polyunsaturated fatty acid (PUFA) (p = 0.017) were observed in the longissimus dorsi muscle of pigs fed NCG when compared with those fed the control diet. As for adipose tissues, the C20:1 (p = 0.045) proportion in dorsal subcutaneous adipose (DSA), as well as the stearic acid (C18:0) (p = 0.018) level in perirenal adipose (PA) were decreased when pigs were fed the NCG diet compared with those of the control diet. In contrast, the margaric acid (C17:0) (p = 0.043) proportion in PA were increased. Moreover, the NCG diet produced PA with a greater proportion of total PUFAs (p = 0.001) (particularly linoleic acid (C18:2n6c) (p = 0.001)) compared with those produced by the control diet. These findings suggest that dietary NCG has beneficial effects by decreasing the shear force and improving the healthfulness of fatty acid profiles, providing a novel strategy for enhancing meat quality of pigs.

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Section: Carcass Trait and Meat Quality Measurementsmentioning

confidence: 99%

Meat Quality and Fatty Acid Profiles of Chinese Ningxiang Pigs Following Supplementation with N-Carbamylglutamate

Xing

Xie

et al. 2020

Animals

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“…All pigs were housed in the animal facilities of the Institute of Animal Science in the Guangdong Academy of Agricultural Sciences. Pigs were fed with a corn-soybean meal-based diet (Table 1 , meeting requirements for finishing pigs according to NRC (1998), without (as controls) or with 15 mg/kg db-cAMP (98 % purity, Hangzhou Meiya Biotechnology Co, Ltd, Hangzhou, China) as described by Wang et al [ 38 ] (note: experiment 1 stands for the earlier phase of fattening pigs; experiment 2 stands for the later phase of fattening pigs).…”

Section: Methodsmentioning

confidence: 99%

“…In recent years, dietary db-cAMP has been used in the pig production with beneficial effect on increasing the content of lean meat and decreasing fat in pig carcasses [ 39 ]. Our previous work [ 38 ] also showed that db-cAMP increased the lean percentage and decreased the backfat thickness, while it did not affect the growth performance or meat quality, indicating that db-cAMP may have potential for producing more lean meat as a feed additive in pig production. Some reports indicated that db-cAMP decreased the size of adipocytes, inhibited fat deposition in adipocytes, and reduced proliferation and differentiation of the preadipocytes [ 21 , 38 ].…”

Section: Introductionmentioning

confidence: 98%

“…Our previous work [ 38 ] also showed that db-cAMP increased the lean percentage and decreased the backfat thickness, while it did not affect the growth performance or meat quality, indicating that db-cAMP may have potential for producing more lean meat as a feed additive in pig production. Some reports indicated that db-cAMP decreased the size of adipocytes, inhibited fat deposition in adipocytes, and reduced proliferation and differentiation of the preadipocytes [ 21 , 38 ]. As cAMP is well-known for many hormones mediating signal transduction, and promoting lipolysis through adenylyl cyclase-cAMP-protein kinase pathway [ 4 , 6 ], it seemed likely that exogenous db-cAMP also played functions through the endocrine and cell signaling pathway.…”

Section: Introductionmentioning

confidence: 98%

“…Dibutyryl cAMP (db-cAMP), an orally active cell-permeant derivative of cAMP, has the same functions as endogenous cAMP, the latter playing a crucial role of signal transduction in numerous biological activities, such as regulating cell growth, enzyme activities, lipolysis, and gene expression [ 31 , 38 ]. In recent years, dietary db-cAMP has been used in the pig production with beneficial effect on increasing the content of lean meat and decreasing fat in pig carcasses [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

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Dibutyryl-cAMP affecting fat deposition of finishing pigs by decreasing the inflammatory system related to insulin sensitive or lipolysis

Fang

Jiang

et al. 2016

Genes Nutr

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BackgroundThe mechanism of db-cAMP regulating fat deposition and improving lean percentage is unclear and needs to be further studied.MethodsEighteen 100-day-old Duroc × Landrance × Large White barrows (49.75 ± 0.75 kg) were used for experiment 1, and 15 eighteen 135-day-old barrows (78.34 ± 1.22 kg) were used for experiment 2 to investigate the effects of dietary dibutyryl-cAMP (db-cAMP) on fat deposition in finishing pigs. Pigs were fed with a corn-soybean meal-based diet supplemented with 0 or 15 mg/kg db-cAMP, and both experiments lasted 35 days, respectively.ResultsThe results showed that db-cAMP decreased the backfat thickness, backfat percentage, and diameter of backfat cells without changing the growth performance or carcass characteristics in both experiments, and this effect was more marked in experiment 1 than in experiment 2; db-cAMP enhanced the activity of the growth hormone–insulin-like growth factor-1 (GH-IGF-1) axis and pro-opiomelanocortin (POMC) system in both experiments, which suppressed the accumulation of backfat deposition; microarray analysis showed that db-cAMP suppressed the inflammatory system within the adipose tissue related to insulin sensitivity, which also reduced fat synthesis.ConclusionsIn summary, the effect of db-cAMP on suppressing fat synthesis and accumulation is better in the earlier phase than in the later phase of finishing pigs, and db-cAMP plays this function by increasing the activity of the GH-IGF-1 axis and POMC system, while decreasing the inflammatory system within the adipose tissue related to insulin sensitive or lipolysis.

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Dietary dibutyryl cAMP supplementation regulates the fat deposition in adipose tissues of finishing pigs via cAMP/PKA pathway

Zhu

Wang

Nie

et al. 2021

Animal Biotechnology

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Effects of dibutyryl cAMP on growth performance and carcass traits in finishing pigs

Cited by 6 publications

References 35 publications

Meat Quality and Fatty Acid Profiles of Chinese Ningxiang Pigs Following Supplementation with N-Carbamylglutamate

Meat Quality and Fatty Acid Profiles of Chinese Ningxiang Pigs Following Supplementation with N-Carbamylglutamate

Dibutyryl-cAMP affecting fat deposition of finishing pigs by decreasing the inflammatory system related to insulin sensitive or lipolysis

Dietary dibutyryl cAMP supplementation regulates the fat deposition in adipose tissues of finishing pigs via cAMP/PKA pathway

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