Effects of dichlorvos (DDVP) inhalation on the activity of acetylcholinesterase in the bronchial tissue of rats

Schmídt, G.; Schmidt, Michael; Nenner, M; Vetterlein, F.

doi:10.1007/bf00353711

Cited by 10 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The predominant mode of DDVP toxicity is by inhibition of cholinesterase, like other organophosphates (Reuber, 1981;DiGiacomo et al, 1987;Pauluhn et al, 1987;Schmidt et al, 1979;Ecobichon, 1991). Thus, they cause signs of toxicity including those resulting from stimulation of the muscarinic receptors of the parasympathetic autonomic nervous system (increased secretions, bronchoconstriction, miosis, diarrhea, urination, bradicardia) (Aas et al, 1987;Ecobichon, 1991).…”

Section: Lower Doses Of Dichlorvos Revealed No Electromyographic Chanmentioning

confidence: 95%

“…Earlier studies have shown that inhalation of the organophosphate dichlorvos potently inhibits the AChE of the rat in the respiratory system and diaphragm (Pauluhn et al, 1987;Schmidt et al, 1979). Williams et al have shown that exposure to multiple low doses of organophosphates produces additive inhibition of acetylcholinesterase .…”

Section: Effects Of Dichlorvos On Respiratory System 205mentioning

confidence: 97%

“…The toxic effects of a large number of organophosphorus compounds are due to their inhibition of acetylcholine esterase (AChE) activity (Schmidt et al, 1979;DiGiacomo et al, 1987;Pauluhn et al, 1987;Ecobichon, 1991;Kelly et al, 1994Kelly et al, , 1997. Earlier studies have shown that inhalation of the organophosphate dichlorvos potently inhibits the AChE of the rat in the respiratory system and diaphragm (Pauluhn et al, 1987;Schmidt et al, 1979).…”

Section: Effects Of Dichlorvos On Respiratory System 205mentioning

confidence: 97%

See 2 more Smart Citations

Electrophysiological and Histopathological Evaluation of Respiratory Tract, Diaphragm, and Phrenic Nerve After Dichlorvos Inhalation in Rats

Atış

Çömelekoğlu

Coşkun

et al. 2002

Inhalation Toxicology

View full text Add to dashboard Cite

The aim of this study was to investigate the dose-related effects of dichlorvos inhalation on electrophysiological alterations of diaphragm and phrenic nerve and the changes in the histologic structure of respiratory system. This study was performed on 33 rats divided into 5 groups, inhaling 1, 2, 5, 10, and 15 microg/L of dichlorvos, respectively. Electrodiagnostic investigations of diaphragm and phrenic nerve were made before and after inhalations. Aspiration samples were taken from lungs to evaluate the presence of infection agents. The airways, lungs, and diaphragms were dissected out for histologic investigation. Rats exposed to a low concentration of dichlorvos (1-5 microg/L) showed no symptoms of intoxication, but exposure to higher doses (10-15 microg/L) induced dyspnea in several animals. Lower doses of dichlorvos revealed no electromyographic changes on diaphragm, whereas higher doses revealed a clear neuropathic involvement. Delayed phrenic nerve motor conduction velocity was noted for each group (p <.05). Morphologic changes on the tracheal epithelium, hyperplasia, thickening of the blood-air barrier, degeneration in alveoli, and ductus alveolaris were seen in histopathologic investigation. In conclusion, the acute inhalation of dichlorvos caused clear evidence of neuropathic involvement of the diaphragm and the phrenic nerve. Also, toxic pneumonitis and injury to the tracheal epithelial were noticed.

show abstract

Section: Lower Doses Of Dichlorvos Revealed No Electromyographic Chanmentioning

confidence: 95%

Section: Effects Of Dichlorvos On Respiratory System 205mentioning

confidence: 97%

Section: Effects Of Dichlorvos On Respiratory System 205mentioning

confidence: 97%

See 1 more Smart Citation

Electrophysiological and Histopathological Evaluation of Respiratory Tract, Diaphragm, and Phrenic Nerve After Dichlorvos Inhalation in Rats

Atış

Çömelekoğlu

Coşkun

et al. 2002

Inhalation Toxicology

View full text Add to dashboard Cite

show abstract

Organophosphorus Compounds

Storm¹

2001

Patty's Toxicology

View full text Add to dashboard Cite

Organophosphate pesticides are a highly diverse group of chemicals to which workers may be exposed during manufacture and formulation and during or after application for their intended uses. They are all characterized by their ability to inhibit the enzyme acetylcholinesterase (AChE) that deactivates the neurotransmitter acetylcholine (ACh). Compounds in this class are numerous and have been categorized in many ways according to the nature of the substituents. Gallo and Lawryk, for example, categorized them into four main categories (Groups I‐IV) based on the characteristics of the leaving group (X). Group I compounds, phosphorylcholines, have a leaving group that contains a quaternary nitrogen and are among the most potent organophosphates (e.g., Shradan). Group II compounds, fluorophosphates, have a fluoride leaving group and are also generally highly toxic (e.g., diisopropyl fluorophosphate). Group III compounds have leaving groups that contain cyanide or a halogen other than fluoride and are generally less potent than Groups I or II (e.g., Parathion). Group IV contains most of the organophosphates used as insecticides today. These compounds have alkoxy, alkylthio, aryloxy, arylthio or heterocyclic leaving groups and a wide variety of other substituents. Another classification scheme is based on the nature of the atoms that immediately surround the central phosphorus atom and results in 14 different categories. According to this scheme, phosphates are the prototype for the entire class and are those compounds where all four atoms that surround the phosphorus atom are oxygen (e.g., dichlorvos, mevinphos). Sulfur‐containing organophosphate compounds (phosphorothioates; phosphorothiolates; phosphorodithioates; phosphorodithiolates) are far more numerous than phosphates and include well recognized organophosphate insecticides such as parathion, diazinon, chlorpyrifos, etc. Other groups contain nitrogen (phosphoramides and phosphorodiamides), nitrogen and sulfur (phosphoramidothionates and phosphoramidothiolates), carbon (phosphonates and phosphinates), or carbon and sulfur (phosphonothionates, phosphonothionothiolates and phosphinothionates). All aspects of organophosphate chemistry, toxicity, analysis, and exposure potential have been previously reviewed. Additionally information regarding the toxicity of this class of compounds has expanded greatly in recent years as a result of toxicity data supplied by registrants to the U.S. EPA's Office of Pesticides to support reregistration. These data are being made publically available by the U.S. EPA on their internet web site. The following discussion draws heavily from recent reviews but also includes summaries of relevant toxicity data submitted to the U.S. EPA available when this chapter was completed. Due to space limitations detailed data reviews are included here for only 30 organophosphate pesticides. Information on other pesticides registered or undergoing reregistration in the United States can be readily obtained from the previously mentioned website.

show abstract

Dichlorvos [MAK Value Documentation in German language, 1986]

2012

The MAK‐Collection for Occupational Health and Safety

View full text Add to dashboard Cite

Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 11. Lieferung, Ausgabe 1986 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Erfahrungen beim Menschen Tierexperimentelle Befunde Akute Toxizität Chronische Toxizität und Versuche zur Kanzerogenität Versuche zur Reproduktionstoxizität Begründung des MAK‐Wertes

show abstract

Effects of dichlorvos (DDVP) inhalation on the activity of acetylcholinesterase in the bronchial tissue of rats

Cited by 10 publications

References 25 publications

Electrophysiological and Histopathological Evaluation of Respiratory Tract, Diaphragm, and Phrenic Nerve After Dichlorvos Inhalation in Rats

Electrophysiological and Histopathological Evaluation of Respiratory Tract, Diaphragm, and Phrenic Nerve After Dichlorvos Inhalation in Rats

Organophosphorus Compounds

Dichlorvos [MAK Value Documentation in German language, 1986]

Contact Info

Product

Resources

About