Effects of Diet and Simvastatin on Fatty Acid Composition in Hypercholesterolemic Men

Jula, Antti; Marniemi, Jukka; Rönnemaa, Tapani; Virtanen, Arja; Huupponen, Risto

doi:10.1161/01.atv.0000177812.84927.fa

Cited by 66 publications

(50 citation statements)

References 30 publications

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“…Recently, Jula et al reported that simvastatin decreased proportions from the total fatty acids of palmitic acid by 2.0%, and increased the sum of long-chain polyunsaturated fatty acids (PUFAs) by 9.0% in the serum of hypercholesterolemic men. 38 It has been reported that palmitic acid is a potential TLR4 ligand and that PUFAs antagonize this effect. 39,40 According to these data, there is a possibility that statin-induced changes in the fatty acid composition might also be involved in the suppression of inflammatory gene expressions.…”

Section: Discussionmentioning

confidence: 99%

Effects of Statins on Adipose Tissue Inflammation

Abe

Matsuda

Kobayashi

et al. 2008

ATVB

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Objectives-Macrophage-mediated chronic inflammation of adipose tissue is causally linked to insulin resistance in obesity. The beneficial effects of 3-hydroxy-3-methylglutaryl (HMG) coenzyme A (CoA) reductase inhibitors (statins) on glucose metabolism have been suggested, but the effects of these agents on adipose tissue inflammation are unclear.The aim of the present study is to define the effects of statins on adipose tissue inflammation and macrophages. Methods and Results-Pravastatin

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Section: Discussionmentioning

confidence: 99%

Effects of Statins on Adipose Tissue Inflammation

Abe

Matsuda

Kobayashi

et al. 2008

ATVB

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“…The Nutrition, environment and health study (the Fishermen study) on professional Baltic Sea area fishermen, their wives, and other family members was conducted in -2005(Turunen et al, 2008. A total of 309 volunteers, aged 22-74 years, and living near Helsinki and Turku study centres participated in a health examination study and of those, 123 men and 132 women had complete dietary, health questionnaire, and basic health examination data for the present work.…”

Section: Study Populationsmentioning

confidence: 99%

“…Serum concentrations of fatty acids were analysed using a gas chromatograph and flame ionisation detector (Jula et al, 2005). The sum of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) (namely omega-3 PUFAs) was calculated as a proportion from all serum fatty acids (% FAs).…”

Section: Laboratory Analysesmentioning

confidence: 99%

Fish consumption, omega-3 fatty acids, and environmental contaminants in relation to low-grade inflammation and early atherosclerosis

Turunen

Jula

Suominen

et al. 2013

Environmental Research

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Background Fish consumption and omega-3 polyunsaturated fatty acid (PUFA) intake are shown to protect from cardiovascular diseases (CVD). However, most fish contain environmental contaminants such as dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), and methylmercury (MeHg) that may have adverse effects on cardiovascular health.Objective Our aim was to elucidate the associations of fish consumption, omega-3 PUFAs, environmental contaminants with low-grade inflammation, early atherosclerosis, and traditional CVD risk factors. Results Serum triglyceride decreased across omega-3 PUFA tertiles in both sexes and studies. MethodsInsulin resistance, C-reactive protein, tumour necrosis factor α, and interleukin 6 decreased across omega-3 PUFA tertiles among the Health 2000 survey participants. Among the Fishermen study men, insulin resistance and arterial stiffness indicated by β-stiffness index tended to increase and the RR estimate for carotid artery plaque tended to decrease across tertiles of PCDD/F+PCB and MeHg. Conclusion Previously established hypotriglyceridemic and anti-inflammatory effects of omega-3PUFAs were seen also in this study. The hypothesised favourable effect on insulin sensitivity and arterial elasticity was suggested to be counteracted by high exposure to environmental contaminants but the effect on plaque prevalence appeared not to be harmful.

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“…Serum fatty acids (proportion from all serum fatty acids, % FAs) were analyzed using a gas chromatograph and flame ionization detector (Jula et al, 2005). Omega-3 PUFAs were defined here as the sum of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA).…”

Section: Data Collectionmentioning

confidence: 99%

Dioxins, polychlorinated biphenyls, methyl mercury and omega-3 polyunsaturated fatty acids as biomarkers of fish consumption

et al. 2010

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Background/Objectives: To assess biomarkers and frequency questions as measures of fish consumption. Subjects/Methods: Participants in the Fishermen substudy numbered 125 men and 139 women (aged 22-74), and in the Health 2000 substudy, 577 men and 712 women (aged 45-74) participated. The aim of the Fishermen study was to examine the overall health effect of fish consumption in a high-consumption population, whereas the aim of the Health 2000 substudy was to obtain in-depth information on cardiovascular diseases and diabetes. Fish consumption was measured by the same validated food frequency questionnaire (FFQ) in both the studies, with a further two separate frequency questions used in the Fishermen substudy. Dioxins, polychlorinated biphenyls (PCBs) and methyl mercury (MeHg) (in the Fishermen substudy alone), and omega-3 polyunsaturated fatty acids (omega-3 PUFAs) (in both studies) were analyzed from fasting serum/blood samples. Results: The Spearman's correlation coefficients between FFQ fish consumption and dioxins, PCBs, MeHg and omega-3 PUFAs were respectively 0.46, 0.48, 0.43 and 0.38 among the Fishermen substudy men, and 0.28, 0.36, 0.45 and 0.31 among women. Similar correlation coefficients were observed between FFQ fish consumption and serum omega-3 PUFAs in the Health 2000 substudy, and also between FFQ fish consumption and the frequency questions on fish consumption in the Fishermen substudy. According to multiple regression modeling and LMG metrics, the most important fish consumption biomarkers were dioxins and PCBs among the men and MeHg among the women. Conclusions: Environmental contaminants seemed to be slightly better fish consumption biomarkers than omega-3 PUFAs in the Baltic Sea area. The separate frequency questions measured fish consumption equally well when compared with the FFQ.

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Effects of Diet and Simvastatin on Fatty Acid Composition in Hypercholesterolemic Men

Cited by 66 publications

References 30 publications

Effects of Statins on Adipose Tissue Inflammation

Effects of Statins on Adipose Tissue Inflammation

Fish consumption, omega-3 fatty acids, and environmental contaminants in relation to low-grade inflammation and early atherosclerosis

Dioxins, polychlorinated biphenyls, methyl mercury and omega-3 polyunsaturated fatty acids as biomarkers of fish consumption

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