Effects of Diet, Chronic Inactivity, and Exercise on Growth Performance and Dehydrogenase Activities in Hepatic and Adipose Tissues

Dietary protein and lipid metabolism in refed rats

“…Depression of HMPD activity following the inclusion of fat in the diet has also been found in rats not subjected to previous periods of fasting or starvation (Vaughan and Winders, 1964;Baldwin ^ al., 1966;and Konishi, 1966). Substitution of fat for either casein or sucrose, even at the 15% level markedly reduced the HMPD activity and further substitution continued this trend (Vaughan and Winders, 1964).…”

“…Depression of activity by dietary fat has also been reported. Konishi (1966) fed weanling rats diets containing 10 or 45% fat and 25% casein for 12 weeks. Fat was added to the diet at the expense of sucrose.…”

“…But one pattern seems to emerge: in creasing dietary protein beyond adequate levels of intake seems to depress HMPD activity, as demonstrated by the study reported by Konishi (1966). Weanling rats were fed for 12 weeks a diet containing 10% fat and 25 or 55% casein.…”

“…The failure of dietary fat to sup press the induction of HMPD was unexpected. However, in the studies reporting suppression of epididymal HMPD activity by dietary fat, the level of dietary protein had been adequate (Leveille, 1967b(Leveille, , 1967cKonishi, 1966;Fabry et al, 1970).…”

Étude des activités enzymatiques du foie et du tissu adipeux épididymaire du rat Wistar H au cours de l'administration à long terme d'un régime hyperlipidique

“…L'étude de l'obésité, en dehors de l'expérience clinique, porte principalement sur des rats ou des souris ayant soit des anomalies génétiques, soit des lésions des noyaux ventro-médians de l'hypotha lamus, soit adaptés à manger un repas par jour [6,9, 33], soit restreints dans leur activité spontanée [23] ou recevant des injections répétées d'insuline, ou bien encore gavés par sonde gastrique. Bien que beau coup de travaux paraissent, qui concernent les effets des régimes alimentaires sur les activités enzymatiques des tissus animaux, assez peu d'auteurs se sont intéressés à notre connaissance aux modi fications enzymatiques intervenant au cours de l'installation de l'obésité par administration de régimes hyperlipidiques à long terme.…”