Effects of dietary acetaminophen and vitamin C supplements on stress and inflammatory responses in Korean native cattle vaccinated with foot-and-mouth disease vaccine - a short communication

Son, Song-Ee; Kim, Suk; Lee, Hu-Jang

doi:10.24099/vet.arhiv.0218

Cited by 3 publications

(9 citation statements)

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“…One probable reason for these clinical findings may be attributed to the circulatory insufficiency caused due to myocarditis. Our study’s results agree with the previous investigations that recorded myocarditis in FMD-infected young calves under 2 months of age 8 , 9 , 23 , 24 . The affinity of FMDV to actively growing myocardial cells may be the cause of myocarditis due to FMD infection in young calves 9 .…”

Section: Discussionsupporting

confidence: 93%

“…Our study’s results agree with the previous investigations that recorded myocarditis in FMD-infected young calves under 2 months of age 8 , 9 , 23 , 24 . The affinity of FMDV to actively growing myocardial cells may be the cause of myocarditis due to FMD infection in young calves 9 . Studies report the entry of FMDV into heart cells is suspected to involve the attachment of the RGD loop of VP 1 protein on viral capsid to the host integrins on the surface of the target cell 25 , 26 .…”

Section: Discussionsupporting

confidence: 93%

“…In the present study, 4 calves under 2 months old suspected clinically of myocarditis died. Previous studies also reported the sudden death of FMD-infected young calves due to damage to the myocardium 9 .…”

Section: Discussionmentioning

confidence: 90%

“…However, adult ruminants’ mortality is low but higher in young animals due to acute myocarditis 5 – 7 . In calves, myocarditis is considered a fatal form of FMD as the affected calves die suddenly without showing any clinical signs 7 – 9 . In field conditions, diagnosis of FMDV-induced myocarditis is very challenging.…”

Section: Introductionmentioning

confidence: 99%

“…It is done based on the history of FMD outbreaks in the region, the incidence of the sudden death of young calves, physical examination, and cardiac auscultation. The estimation of serum cardiac troponin I (cTn I), aspartate aminotransferase (AST), creatinine kinase myocardial band (CK-MB), and lactate dehydrogenase (LDH) have been used as diagnostic biomarkers 9 – 11 . The release of cTn I and other enzymes into circulation as a response to myocardial injury or damage.…”

Section: Introductionmentioning

confidence: 99%

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Foot-and-mouth disease-associated myocarditis is age dependent in suckling calves

Deka,

Das,

Hazarika

et al. 2024

Sci Rep

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Myocarditis is considered a fatal form of foot-and-mouth disease (FMD) in suckling calves. In the present study, a total of 17 calves under 4 months of age and suspected clinically for FMD were examined for clinical lesions, respiratory rate, heart rate, and heart rhythm. Lesion samples, saliva, nasal swabs, and whole blood were collected from suspected calves and subjected to Sandwich ELISA and reverse transcription multiplex polymerase chain reaction (RT-mPCR) for detection and serotyping of FMD virus (FMDV). The samples were found to be positive for FMDV serotype “O”. Myocarditis was suspected in 6 calves based on tachypnoea, tachycardia, and gallop rhythm. Serum aspartate aminotransferase (AST), creatinine kinase myocardial band (CK-MB) and lactate dehydrogenase (LDH), and cardiac troponins (cTnI) were measured. Mean serum AST, cTn-I and LDH were significantly higher (P < 0.001) in < 2 months old FMD-infected calves showing clinical signs suggestive of myocarditis (264.833 ± 4.16; 11.650 ± 0.34 and 1213.33 ± 29.06) than those without myocarditis (< 2 months old: 110.00 ± 0.00, 0.06 ± 0.00, 1050.00 ± 0.00; > 2 months < 4 months: 83.00 ± 3.00, 0.05 ± 0.02, 1159.00 ± 27.63) and healthy control groups (< 2 months old: 67.50 ± 3.10, 0.047 ± 0.01, 1120.00 ± 31.62; > 2 months < 4 months: 72.83 ± 2.09, 0.47 ± 0.00, 1160.00 ± 18.44). However, mean serum CK-MB did not differ significantly amongst the groups. Four calves under 2 months old died and a necropsy revealed the presence of a pathognomic gross lesion of the myocardial form of FMD known as “tigroid heart”. Histopathology confirmed myocarditis. This study also reports the relevance of clinical and histopathological findings and biochemical markers in diagnosing FMD-related myocarditis in suckling calves.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Foot-and-mouth disease-associated myocarditis is age dependent in suckling calves

Deka,

Das,

Hazarika

et al. 2024

Sci Rep

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Effect of Ascorbic Acid Supplementation on Fecal Immunoglobulin A in Japanese Black Calves

Otomaru

Oishi

Fujimura

et al. 2022

JARQ

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Effects of Acetaminophen and Vitamin C Combination on Clinical Vital Signs and Behavioral Traits of Heat-Stressed Dairy Buffalo

Sangor,

Al-Kanaan,

Khudhair

2024

Adv. life sci.

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Background: Heat stress (HS) presents significant challenges to water buffalo breeding, particularly in harsh environments like southern Iraq. HS adversely impacts physiological and behavioral aspects in dairy buffaloes, leading to economic losses in productivity and welfare. Interventions such as acetaminophen and vitamin C supplementation have been suggested to alleviate HS impacts due to their anti-stress and anti-inflammatory characteristics.Methods: This study was conducted in Al-Chibayish Marshes southern Iraq and aimed to evaluate the effects of acetaminophen and vitamin C combination (AVC) on heat-stressed dairy buffalo. Sixteen lactating buffaloes were divided into four treatments. One treatment received regular water (control), while other treatments were given water mixed with AVC at a dose of 500g/1000 liters for 3, 5, and 7 consecutive days per week, respectively, over 30 days. Environmental (temperature, humidity, and THI) and physiological data (body temperature, respiration rate, and pulse rate) were recorded daily, while feed and water consumption were recorded weekly.Results: Buffaloes experienced significant HS, with temperatures reaching up to 53.2°C and corresponding THI values ranging from 88.05 to 99.31. AVC administration for 5 consecutive days led to increased feed intake by 1.15 kg daily per treatment and decreased water consumption by 16.43 liters daily per treatment compared to the control. Additionally, rectal temperature, respiration rate, and heart rate showed progressive improvement during the second and third weeks, with the most notable improvement observed in the fourth week of the study. These improvements in vital signs and behavioral traits indicate the ability of AVC to improve thermoregulation and reduce heat stress impact.Conclusion: The investigation highlights the potential of AVC supplementation showing a promise in alleviating HS effects on dairy buffaloes by positively influencing physiological and behavioral parameters. Further research is needed to elucidate the underlying mechanisms and optimize supplementation strategies for enhancing buffalo welfare and productivity under heat stress.Keywords: Acetaminophen; Vitamin C; Physiological; Behavioral; Heat stress; Buffalo

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Effects of dietary acetaminophen and vitamin C supplements on stress and inflammatory responses in Korean native cattle vaccinated with foot-and-mouth disease vaccine - a short communication

Cited by 3 publications

References 0 publications

Foot-and-mouth disease-associated myocarditis is age dependent in suckling calves

Foot-and-mouth disease-associated myocarditis is age dependent in suckling calves

Effect of Ascorbic Acid Supplementation on Fecal Immunoglobulin A in Japanese Black Calves

Effects of Acetaminophen and Vitamin C Combination on Clinical Vital Signs and Behavioral Traits of Heat-Stressed Dairy Buffalo

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