Effects of dietary and lifestyle recommendations on patients with glaucoma: A randomized controlled pilot trial

Hecht, Idan; Achiron, Asaf; Bartov, Elisha; Maharshak, Idit; Mendel, Liat; Pe’er, Liron; Bar, Asaf; Burgansky-Eliash, Zvia

doi:10.1016/j.eujim.2018.12.002

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…The few clinical investigations that have been conducted on individuals with POAG have examined any potential ocular hypotensive effects, and their findings have been conflicting. Saffron supplementation (1 g twice a week) in a randomized controlled pilot study did not seem to have an impact on IOP in the near term (1 month) [67]. However, according to a different pilot study carried out on 34 clinically stable POAG patients, oral saffron supplementation (30 mg daily for one month) can considerably lower IOP after three weeks.…”

Section: Crocus Sativus L (Saffron)mentioning

confidence: 94%

Herbal and Natural Treatments for the Management of the Glaucoma: An Update

Vitiello,

Capasso,

Cembalo

et al. 2023

BioMed Research International

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Glaucoma causes the degeneration of the retinal ganglion cells (RGCs) and their axons, inducing a tissue reshaping that affects both the retina and the optic nerve head. Glaucoma care especially focuses on reducing intraocular pressure, a significant risk factor for progressive damage to the optic nerve. The use of natural treatments, such as herbs, vitamins, and minerals, is becoming increasingly popular today. While plants are a rich source of novel biologically active compounds, only a small percentage of them have been phytochemically examined and evaluated for their medicinal potential. It is necessary for eye care professionals to inform their glaucoma patients about the therapy, protection, and efficacy of commonly used herbal medicines, considering the widespread use of herbal medicines. The purpose of this review is to examine evidence related to the most widely used herbal medicines for the management and treatment of glaucoma, to better understand the potential benefits of these natural compounds as supplementary therapy.

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Section: Crocus Sativus L (Saffron)mentioning

confidence: 94%

Herbal and Natural Treatments for the Management of the Glaucoma: An Update

Vitiello,

Capasso,

Cembalo

et al. 2023

BioMed Research International

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“…Conversely, a single clinical study reported a decrease of only 1 mmHg in the intraocular pressure of normotensive subjects after the oral supplementation with omega-3 [ 235 ]. Additionally, the dietary supplementation of natural extracts based on Ginkgo biloba, green tea catechins, saffron, and black currant anthocyanins demonstrated antioxidant and neuroprotective properties in animal models [ 236 , 237 , 238 ] but no clinical efficacy to treat glaucoma [ 239 , 240 , 241 , 242 , 243 ].…”

Section: Treatmentmentioning

confidence: 99%

From Oxidative Stress to Inflammation in the Posterior Ocular Diseases: Diagnosis and Treatment

et al. 2021

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Most irreversible blindness observed with glaucoma and retina-related ocular diseases, including age-related macular degeneration and diabetic retinopathy, have their origin in the posterior segment of the eye, making their physiopathology both complex and interconnected. In addition to the age factor, these diseases share the same mechanism disorder based essentially on oxidative stress. In this context, the imbalance between the production of reactive oxygen species (ROS) mainly by mitochondria and their elimination by protective mechanisms leads to chronic inflammation. Oxidative stress and inflammation share a close pathophysiological process, appearing simultaneously and suggesting a relationship between both mechanisms. The biochemical end point of these two biological alarming systems is the release of different biomarkers that can be used in the diagnosis. Furthermore, oxidative stress, initiating in the vulnerable tissue of the posterior segment, is closely related to mitochondrial dysfunction, apoptosis, autophagy dysfunction, and inflammation, which are involved in each disease progression. In this review, we have analyzed (1) the oxidative stress and inflammatory processes in the back of the eye, (2) the importance of biomarkers, detected in systemic or ocular fluids, for the diagnosis of eye diseases based on recent studies, and (3) the treatment of posterior ocular diseases, based on long-term clinical studies.

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“…In glaucoma, there are two studies in patients on the possible hypotensive effect of saffron that show contradictory results. In patients with primary open-angle glaucoma, using a dose of 1g twice a week, no hypotensive effect was observed [101]. However, in another study using a dose of 30 mg per day, a decrease in intraocular pressure (IOP) was found [102].…”

Section: Saffronmentioning

confidence: 99%

Searching for the Antioxidant, Anti-Inflammatory, and Neuroprotective Potential of Natural Food and Nutritional Supplements for Ocular Health in the Mediterranean Population

Valero-Velló

Peris-Martínez

García-Medina

et al. 2021

Foods

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Adherence to a healthy diet offers a valuable intervention to compete against the increasing cases of ocular diseases worldwide, such as dry eye disorders, myopia progression, cataracts, glaucoma, diabetic retinopathy, or age macular degeneration. Certain amounts of micronutrients must be daily provided for proper functioning of the visual system, such as vitamins, carotenoids, trace metals and omega-3 fatty acids. Among natural foods, the following have to be considered for boosting eye/vision health: fish, meat, eggs, nuts, legumes, citrus fruits, nuts, leafy green vegetables, orange-colored fruits/vegetables, olives-olive oil, and dairy products. Nutritional supplements have received much attention as potential tools for managing chronic-degenerative ocular diseases. A systematic search of PubMed, Web of Science, hand-searched publications and historical archives were performed by the professionals involved in this study, to include peer-reviewed articles in which natural food, nutrient content, and its potential relationship with ocular health. Five ophthalmologists and two researchers collected the characteristics, quality and suitability of the above studies. Finally, 177 publications from 1983 to 2021 were enclosed, mainly related to natural food, Mediterranean diet (MedDiet) and nutraceutic supplementation. For the first time, original studies with broccoli and tigernut (chufa de Valencia) regarding the ocular surface dysfunction, macular degeneration, diabetic retinopathy and glaucoma were enclosed. These can add value to the diet, counteract nutritional defects, and help in the early stages, as well as in the course of ophthalmic pathologies. The main purpose of this review, enclosed in the Special Issue “Health Benefits and Nutritional Quality of Fruits, Nuts and Vegetables,” is to identify directions for further research on the role of diet and nutrition in the eyes and vision, and the potential antioxidant, anti-inflammatory and neuroprotective effects of natural food (broccoli, saffron, tigernuts and walnuts), the Mediterranean Diet, and nutraceutic supplements that may supply a promising and highly affordable scenario for patients at risk of vision loss. This review work was designed and carried out by a multidisciplinary group involved in ophthalmology and ophthalmic research and especially in nutritional ophthalmology.

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Effects of dietary and lifestyle recommendations on patients with glaucoma: A randomized controlled pilot trial

Cited by 7 publications

References 26 publications

Herbal and Natural Treatments for the Management of the Glaucoma: An Update

Herbal and Natural Treatments for the Management of the Glaucoma: An Update

From Oxidative Stress to Inflammation in the Posterior Ocular Diseases: Diagnosis and Treatment

Searching for the Antioxidant, Anti-Inflammatory, and Neuroprotective Potential of Natural Food and Nutritional Supplements for Ocular Health in the Mediterranean Population

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