2007
DOI: 10.3177/jnsv.53.133
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Effects of Dietary Angelica keiskei on Serum and Liver Lipid Profiles, and Body Fat Accumulations in Rats

Abstract: Summary Angelica keiskei (Ashitaba) is a perennial plant belonging to the Umbelliferae family. Recently, much attention has been focused on Ashitaba products as a so-called health food for the breakdown of cellulite among various physiological benefits of Ashitaba. The current study was carried out to investigate the physiological efficacy of dietary Ashitaba on serum and liver lipid profiles and body fat accumulation in rats. Rats were fed a high-fat diet with various amounts of Ashitaba for 28 d. Perirenal a… Show more

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Cited by 19 publications
(11 citation statements)
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“…It was suggested that ashitaba extract regulated lipid metabolism in adipose and liver tissue by activating AMP-activated protein kinase [9]. In contrast, male Wistar rats fed a high-fat diet in combination with ashitaba powder at 17, 170, or 1700 mg/100 g body weight for 28 days did not show significant differences in body weight gain, food intake, or relative organ weights when compared to the controls [13]. In a study on six-week-old male stroke-prone spontaneously hypertensive rats SHRSP fed diets containing 0.02% or 0.1% xanthoangelol (0.02 and 0.10 Xan, respectively) for 7 weeks, xanthoangelol was shown to improve lipid metabolism in the serum and liver, resulting in a reduction of the risk for development of atherosclerosis and suppression of hepatic lipid accumulation, parameters of metabolic syndrome [12].…”
Section: Discussionmentioning
confidence: 98%
See 1 more Smart Citation
“…It was suggested that ashitaba extract regulated lipid metabolism in adipose and liver tissue by activating AMP-activated protein kinase [9]. In contrast, male Wistar rats fed a high-fat diet in combination with ashitaba powder at 17, 170, or 1700 mg/100 g body weight for 28 days did not show significant differences in body weight gain, food intake, or relative organ weights when compared to the controls [13]. In a study on six-week-old male stroke-prone spontaneously hypertensive rats SHRSP fed diets containing 0.02% or 0.1% xanthoangelol (0.02 and 0.10 Xan, respectively) for 7 weeks, xanthoangelol was shown to improve lipid metabolism in the serum and liver, resulting in a reduction of the risk for development of atherosclerosis and suppression of hepatic lipid accumulation, parameters of metabolic syndrome [12].…”
Section: Discussionmentioning
confidence: 98%
“…Ashitaba chalcone has a long history of human use as a dietary supplement with claims of multiple health benefits and with many published animal studies without toxic effects [2]. For example, safety has been demonstrated in Wistar rats at a dose of 1700mg/ kg [13]. In addition, a safe dose of 300mg/kg has been reported in male and female rats [3].…”
Section: Discussionmentioning
confidence: 99%
“…It has been reported that AK contains numerous bioactive substances such as chalcones, coumarines, flavonoids, saponins, and vitamins and exhibits anti-inflammatory [2328], anti-adiposity [429], anti-oxidant [30], anti-diabetic [3132], anti-hypertensive [5], anti-tumor [67], and anti-memory impairment [33] effects.…”
Section: Discussionmentioning
confidence: 99%
“…Saat ini masyarakat sangat tertarik dengan bahan-bahan alami atau herbal untuk mencegah serta mengobati suatu penyakit karena dinilai sebagai salah satu alternatif pengobatan yang mempunyai efek samping sedikit, murah, serta mudah untuk didapatkan (6). Menurut penelitian, salah satu tumbuhan alami yang mengandung flavonoid adalah Ashitaba (7). Oleh karena hal di atas, penulis ingin meneliti tentang pengaruh pemberian seduhan daun Ashitaba (Angelica keiskei) sebagai obat pendamping simvastatin untuk menurunkan kadar trigliserida tikus putih jantan strain Wistar (Rattus norvegicus) yang dikondisikan hipertrigliseridemia.…”
Section: Pendahulanunclassified