Effects of dietary astaxanthin on growth, blood biochemistry, antioxidant, immune and inflammatory response in lipopolysaccharide‐challenged<i>Channa argus</i>

Zhu, Xin‐Ming; Li, Mu‐Yang; Liu, Xin‐Yu; Xia, Changge; Niu, Xiaotian; Wang, Guiqin; Zhang, Dongming

doi:10.1111/are.14550

Cited by 23 publications

(18 citation statements)

References 52 publications

(60 reference statements)

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“…LZM and NO are the component of fish innate immune system and immunoactive substance (Nathan, 1992; Saeij et al, 2002; Saurabh & Sahoo, 2008). In the present study, results of LZM activity and NO content were similarly to the red swamp crayfish (Cheng & Wu, 2019) and Channa argus (Zhu et al, 2020), indicating that Ast may provide the immune resistance of large yellow croaker larvae through the immunity enzymes (De Pascali et al, 2019).…”

Section: Discussionsupporting

confidence: 71%

Effects of dietary supplementation of astaxanthin (Ast) on growth performance, activities of digestive enzymes, antioxidant capacity and lipid metabolism of large yellow croaker ( Larimichthys crocea ) larvae

Liu

Huang

et al. 2022

Aquaculture Research

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A 30-day feeding experiment was operated to evaluate the impact of astaxanthin (Ast) on growth performance, activities of digestive enzymes, antioxidant responses and lipid metabolism of large yellow croaker (Larimichthys crocea) larvae. Four microdiets (isonitrogenous and isolipidic) were formulated with graded Ast levels (0, 20, 40 and 80 mg/kg) in form of Haematococcus pluvialis powder (0, 0.4, 0.8 and 1.6 g/kg).Results showed that the specific growth rate of larvae was significantly enhanced by supplementation of 80 mg/kg Ast compared to the control group. Meanwhile, the Ast supplementation could significantly improve the digestive capacity of larvae through increasing activities of digestive enzymes, including trypsin in larvae pancreas segments (PS) and intestinal segments (IS), lipase, and alkaline phosphatase in brush border membranes compared to the control group. In terms of antioxidants, Ast supplementation significantly advanced the antioxidant capacity through increasing the activity of total antioxidant capacity and catalase, and reducing content of malondialdehyde. The activity of lysozyme and nitric oxide content of larvae were significantly increased by Ast supplementation compared to the control group. Furthermore, the triglyceride content in visceral mass was significantly reduced by Ast supplementation probably through up-regulating expression of lipid catabolism-related genes (cpt1, lpl, hl, aco, and pparα), and down-regulating expression of lipogenesis-related genes (fas, dgat2, and srebp1) and lipid transport-related genes (fabp11, apoB100, and mtp).In summary, appropriate supplementation of Ast (40-80 mg/kg) could improve the growth performance of large yellow croaker larvae through enhancing of digestive enzymes activities, antioxidant capacity and promoting lipid utilization.

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Section: Discussionsupporting

confidence: 71%

Effects of dietary supplementation of astaxanthin (Ast) on growth performance, activities of digestive enzymes, antioxidant capacity and lipid metabolism of large yellow croaker ( Larimichthys crocea ) larvae

Liu

Huang

et al. 2022

Aquaculture Research

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“…43 Studies have also shown that astaxanthin helped to stabilize lipid in food products, thereby preventing any rancidity that could render foods unfit for consumption. 55 Wang et al 56 and Zu et al 57 reported that astaxanthin, irrespective of the amount, improved growth performance in animals. In addition, the MSCD group had a high content of sulphur amino acids, especially methionine, which is indispensable for protein synthesis and hence growth.…”

Section: Resultsmentioning

confidence: 99%

“…Wang et al 56 . and Zu et al 57 . reported that astaxanthin, irrespective of the amount, improved growth performance in animals.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of nutritional quality of complementary foods formulated from blends of Nigerian yellow maize (Zea mays), soybean (Glycine max) and crayfish (Procambarus clarkii)

et al. 2022

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BACKGROUND: Plant-based complementary foods (CFs) supply insufficient amount of nutrients to meet recommended nutrient intakes for 6-23-month-old children. The present study determined the nutritional quality of CFs formulated from blends of Nigerian yellow maize (Zea mays), soybean (Glycine max) and crayfish (Procambarus clarkii). Three CFs were formulated; namely, maize flour (MF, 100:0% w/w), blends of maize and soybean flour (MSF, 72:28% w/w), and maize, soybean and crayfish flour (MSCF, 80:10:10% w/w). Nutritional quality was evaluated using analyses of chemical composition of CFs and of protein quality of complementary food diets. Data were compared by multivariate analysis of variance and significantly differentiated. Nine selected nutritional criteria were used to decide the CF that had best nutritional characteristics compared to MF and fortified wheat flour (FWMF). RESULTS: Total scores obtained from the selected nutritional criteria ranked MSCF, with total score of 15, as the lowest and thus it was considered to have the most desirable nutritional characteristics compared to MF, MSF and FWMF, which had respective total scores of 31, 22 and 20.CONCLUSION: Conclusively, MSCF may serve as a better alternative CF for MF, MSC and FWMF. The present study has produced a potential alternative cost-effective and adequate CF, formulated from crayfish (P. clarkii) supplementation of locally available blend of yellow maize (Z. mays) and soybean (G. max), for the poor human population, aiming to encourage the consumption of animal-sourced CF for alleviating the prevalence of childhood undernutrition.

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“…It has curative and preventive effects against inflammation, infectious diseases, and oxidative stress [ 54 ]. However, although some research has shown the positive effect of astaxanthin on the immune and inflammatory systems [ 55 , 58 , 59 ], other research presented no such particular changes [ 60 , 61 ]. In our study, regardless of the supplementation dose, astaxanthin did not affect IgM and IgG activities in serum.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, the aforementioned studies dealing with astaxanthin to improve the immune system were for the most implemented on vaccinated or challenged animals. Zhu et al [ 59 ] claimed that fishes show defensive responses under the stimulus of external environment; then, granulocytes and white blood cells are activated to stimulate the inflammatory response and release inflammatory factors. Without challenge, immunoglobulins are less stimulated.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Response to Moderate and High Dose Supplementation of Astaxanthin in Laying Hens

Dansou

Wang

Nugroho

et al. 2021

Animals

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In this study, we evaluated the impact of moderate and high dose dietary supplementation of astaxanthin on production performance, quality of eggs, and health status of laying hens. The experiment involved 480 laying hens, divided into four groups of eight replicates. The different groups named A1, A2, A3, and A4 were allocated the same diet supplemented with Haematococcus pluvialis powder to provide 0, 21.3, 42.6, and 213.4 mg of astaxanthin per kilogram of feed, respectively. One-way ANOVA and linear and quadratic regression analysis were used to assess the differences between the groups. The results showed that the production performance of laying hens and the physical quality of eggs did not significantly differ between the groups (p > 0.05). Astaxanthin distribution in tissues was typical per bird, whereas the egg yolk coloration and astaxanthin concentration increased with the supplementation dose (p < 0.001). However, there was a decrease in concentration and coloration efficacy of astaxanthin at high dose supplementation (213.4 mg/kg) compared to moderate doses (21.3 and 42.6 mg/kg). Blood biochemical tests showed some discrepancies that were not ascribed to the effect of diets, and the increase in liver weight in the A4 group compared to others was equated with an adaptation of laying hens to the high dose supplementation. Astaxanthin improved superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and diminished malondialdehyde (MDA) content in both liver and serum; meanwhile, the activities of SOD and GSH-Px in serum were similar between the moderate doses and high dose supplementation. Additionally, astaxanthin alleviated interleukin 2, 4, and 6 (IL-2, IL-4, and IL-6, respectively) in serum, showing the best effect in A3 and A4 groups. Besides, immunoglobulin G and M (IgG and IgM), as well as tumor necrosis factor-alpha and beta (TNF-α and TNF-β), were not much affected. It was concluded that although astaxanthin has no obvious adverse effect on the performance and health status of laying hens, it may not be valuable for egg fortification and health status improvement of laying hens at high dose supplementation. The high dose astaxanthin supplementation up to 213.4 mg/kg in the diet might be avoided.

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Effects of dietary astaxanthin on growth, blood biochemistry, antioxidant, immune and inflammatory response in lipopolysaccharide‐challengedChanna argus

Cited by 23 publications

References 52 publications

Effects of dietary supplementation of astaxanthin (Ast) on growth performance, activities of digestive enzymes, antioxidant capacity and lipid metabolism of large yellow croaker ( Larimichthys crocea ) larvae

Effects of dietary supplementation of astaxanthin (Ast) on growth performance, activities of digestive enzymes, antioxidant capacity and lipid metabolism of large yellow croaker ( Larimichthys crocea ) larvae

Evaluation of nutritional quality of complementary foods formulated from blends of Nigerian yellow maize (Zea mays), soybean (Glycine max) and crayfish (Procambarus clarkii)

Assessment of Response to Moderate and High Dose Supplementation of Astaxanthin in Laying Hens

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